3.1.99.B2: XPF endonuclease

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For detailed information about XPF endonuclease, go to the full flat file.

Word Map on EC 3.1.99.B2

3.1.99.B2

structure-specific

endonucleases

flap

fanconi

sulfolobus

fork

interstrand

crosslinks

anemia

uv-induced

eukaryal

stalled

slide

nucleases

xpf-ercc1

nicked

crossover

incises

helicase

sliding

helix-hairpin-helix

meiotic

Reaction

The best substrate for the structure-specific endonuclease is a 3' flap followed by a nicked duplex, nicked three-way junctions, and nicked fourway junctions. The enzyme from Sulfolobus is only active in the presence of the sliding clamp PCNA (Proliferating-Cell-Nuclear-Antigen). It cleaves the replication fork or 3'-flap structures in the homodimeric form. =

Synonyms

SsoXPF, xeroderma pigmentosum group F endonuclease, XPF endonuclease, XPF repair endonuclease

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.99.B2 XPF endonuclease

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Results	in table
1	Activating Compound
2	AA Sequence
2	Cloned(Commentary)
2	Crystallization (Commentary)
14	Organism
2	pH Optimum
2	Purification (Commentary)
1	Reaction
8	Reference
6	Substrates and Products (Substrate)
1	Subunits
7	Synonyms
2	Temperature Optimum [°C]
2	Turnover Number [1/s]

pH Optimum

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7.6

Saccharolobus solfataricus

Q7LXL5

assay at

719834, 720486