3.1.99.B2: XPF endonuclease
This is an abbreviated version!
For detailed information about XPF endonuclease, go to the full flat file.
Word Map on EC 3.1.99.B2
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3.1.99.B2
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structure-specific
-
endonucleases
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flap
-
fanconi
-
sulfolobus
-
fork
-
interstrand
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crosslinks
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anemia
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uv-induced
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eukaryal
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stalled
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slide
-
nucleases
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xpf-ercc1
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nicked
-
crossover
-
incises
-
helicase
-
sliding
-
helix-hairpin-helix
-
meiotic
- 3.1.99.B2
-
structure-specific
- endonucleases
- flap
-
fanconi
- sulfolobus
-
fork
-
interstrand
-
crosslinks
- anemia
-
uv-induced
-
eukaryal
-
stalled
-
slide
- nucleases
-
xpf-ercc1
-
nicked
-
crossover
-
incises
- helicase
-
sliding
-
helix-hairpin-helix
-
meiotic
Reaction
The best substrate for the structure-specific endonuclease is a 3' flap followed by a nicked duplex, nicked three-way junctions, and nicked fourway junctions. The enzyme from Sulfolobus is only active in the presence of the sliding clamp PCNA (Proliferating-Cell-Nuclear-Antigen). It cleaves the replication fork or 3'-flap structures in the homodimeric form. =
Synonyms
SsoXPF, xeroderma pigmentosum group F endonuclease, XPF endonuclease, XPF repair endonuclease