3.1.99.B2: XPF endonuclease

This is an abbreviated version!
For detailed information about XPF endonuclease, go to the full flat file.

Word Map on EC 3.1.99.B2

3.1.99.B2

structure-specific

endonucleases

flap

fanconi

sulfolobus

fork

interstrand

crosslinks

anemia

uv-induced

eukaryal

stalled

slide

nucleases

xpf-ercc1

nicked

crossover

incises

helicase

sliding

helix-hairpin-helix

meiotic

Reaction

The best substrate for the structure-specific endonuclease is a 3' flap followed by a nicked duplex, nicked three-way junctions, and nicked fourway junctions. The enzyme from Sulfolobus is only active in the presence of the sliding clamp PCNA (Proliferating-Cell-Nuclear-Antigen). It cleaves the replication fork or 3'-flap structures in the homodimeric form. =

Synonyms

SsoXPF, xeroderma pigmentosum group F endonuclease, XPF endonuclease, XPF repair endonuclease

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.99.B2 XPF endonuclease

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Results	in table
1	Activating Compound
2	AA Sequence
2	Cloned(Commentary)
2	Crystallization (Commentary)
14	Organism
2	pH Optimum
2	Purification (Commentary)
1	Reaction
8	Reference
6	Substrates and Products (Substrate)
1	Subunits
7	Synonyms
2	Temperature Optimum [°C]
2	Turnover Number [1/s]

Reference

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Reference on EC 3.1.99.B2 - XPF endonuclease

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718472

Lally, J.; Newman, M.; Murray-Rust, J.; Fadden, A.; Kawarabayasi, Y.; McDonald, N.

Crystallization of the xeroderma pigmentosum group F endonuclease from Aeropyrum pernix

Acta Crystallogr. Sect. D

1658-1661

2004

Aeropyrum pernix (Q9YC15), Aeropyrum pernix

15333947

719360

Newman, M.; Murray-Rust, J.; Lally, J.; Rudolf, J.; Fadden, A.; Knowles, P.P.; White, M.F.; McDonald, N.Q.

Structure of an XPF endonuclease with and without DNA suggests a model for substrate recognition

EMBO J.

895-905

2005

Aeropyrum pernix (Q9YC15)

15719018

719834

Roberts, J.A.; White, M.F.

An archaeal endonuclease displays key properties of both eukaryal XPF-ERCC1 and Mus81

J. Biol. Chem.

280

5924-5928

2005

Saccharolobus solfataricus (Q7LXL5), Saccharolobus solfataricus, Saccharolobus solfataricus P2 (Q7LXL5)

15591065

720486

Roberts, J.A.; Bell, S.D.;, White, M.F.

An archaeal XPF repair endonuclease dependent on a heterotrimeric PCNA

Mol. Microbiol.

361-371

2003

Saccharolobus solfataricus (Q7LXL5), Saccharolobus solfataricus P2 (Q7LXL5)

12675797

720574

Roberts, J.A.; White, M.F.

DNA end-directed and processive nuclease activities of the archaeal XPF enzyme

Nucleic Acids Res.

6662-6670

2005

Saccharolobus solfataricus (Q7LXL5), Saccharolobus solfataricus P2 (Q7LXL5)

16314325