3.1.99.B1: flap endonuclease-1

This is an abbreviated version, for detailed information about flap endonuclease-1, go to the full flat file.

Reaction

endonucleases that remove 5' DNA sequences from a DNA structure called a DNA flap. The DNA flap structure occurs in double-stranded DNA containing a single-stranded break where the 5' portion of the downstream strand is too long and overlaps the 3' end of the upstream strand. Flap endonucleases cleave the downstream strand of the overlap flap structure precisely after the first base-paired nucleotide, creating a ligatable nick. =

Synonyms

AfFEN, Dna2, FEN, FEN-1, FEN1, FEN1 endonuclease, flap endonuclease, flap endonuclease 1, More, T5 flap endonuclease, T5FEN

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
            
                3.1.99.B1 flap endonuclease-1