3.1.8.2: diisopropyl-fluorophosphatase
This is an abbreviated version!
For detailed information about diisopropyl-fluorophosphatase, go to the full flat file.
Word Map on EC 3.1.8.2
-
3.1.8.2
-
dfpase
-
organophosphorus
-
dfp
-
degradation
-
squid
-
paraoxonase
-
sarin
-
phosphotriesterases
-
paraoxon
-
environmental protection
-
loligo
-
opaas
-
arylesterase
-
bioscavenger
-
vx
-
methylphosphonofluoridate
-
medicine
-
cyclosarin
-
six-bladed
-
carbanilate
-
udp-glucosyltransferase
-
diisopropylphosphorofluoridate
-
2.8.2.1
-
arylsulfotransferase
-
udp-glucuronyltransferase
-
2.3.1.5
-
analysis
- 3.1.8.2
- dfpase
-
organophosphorus
- dfp
- degradation
- squid
- paraoxonase
- sarin
- phosphotriesterases
- paraoxon
- environmental protection
-
loligo
-
opaas
- arylesterase
-
bioscavenger
- vx
- methylphosphonofluoridate
- medicine
- cyclosarin
-
six-bladed
-
carbanilate
- udp-glucosyltransferase
- diisopropylphosphorofluoridate
-
2.8.2.1
- arylsulfotransferase
-
udp-glucuronyltransferase
-
2.3.1.5
- analysis
Reaction
Synonyms
DFPase, di-isopropylphosphorofluoridate fluorohydrolase, dialkylfluorophosphatase, diisopropyl fluorophosphatase, diisopropyl phosphorofluoridate hydrolase, diisopropylfluorophosphatase, diisopropylfluorophosphonate dehalogenase, diisopropylphosphofluoridase, EC 3.8.2.1, h-PON1, isopropylphosphorofluoridase, More, OP-hydrolyzing enzyme, OPA anhydrase, OPA anhydrolase, OPAA, OPAA-2, opd, OPH, organophosphate acid anhydrase, organophosphate anhydrolase/prolidase, organophosphorus acid anhydrolase, organophosphorus hydrolase, organophosphorus-hydrolyzing enzyme, paraoxonase 1, phosphotriesterase, PON1, PTES5, RC, regucalcin, senescence marker protein-30, SMP30, somanase, tabunase
ECTree
3.1.8.2 diisopropyl-fluorophosphataseAdvanced search results
results (
results (Activating Compound
Activating Compound on EC 3.1.8.2 - diisopropyl-fluorophosphatase
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
ACTIVATING COMPOUND 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
triethanolamine
best activator, EDTA abolishes the triethanolamine-induced activation of enzyme OPH
CdCl2
1 mM, stimulates hydrolysis to a lesser extent, 38% activity, compared to MgCl2
CoCl2
1 mM, stimulates hydrolysis well, 102% activity, compared to MgCl2
additional information
-
an approach using recombinant enzyme encapsulated within sterically stabilized liposomes to enhance diisopropyl fluorophosphates degradation
-
additional information
presence of glucose-mineral-salt (GMS) supplemented with tryptone and 100 mg/l Co2+ ion increases the specific activity of the recombinant enzyme
-
additional information
-
presence of glucose-mineral-salt (GMS) supplemented with tryptone and 100 mg/l Co2+ ion increases the specific activity of the recombinant enzyme
-
additional information
organophosphorus hydrolase (OPH)-catalyzed hydrolysis of diisopropylfluorophosphate (DFP), an analogue molecule of G-type warfare agents, is activated by aminoalcohols. OPH reaction are remarkably increased in the buffers containing aminoalcohols with C2 between nitrogen and oxygen in their structures, including triethanolamine (TEA), diethanolamine, monoethanolamine, 1-amino-2-propanol, 2-amino-2-methyl-1-propanol, and triisopropanolamine. The activation of OPH by aminoalcohol buffers can be attributed to the reduction of fluoride inhibition, which would be beneficial to the hydrolase-based detoxification of organophosphofluoridate
-
