3.1.7.1: prenyl-diphosphatase

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For detailed information about prenyl-diphosphatase, go to the full flat file.

Reaction

Synonyms

allyl diphosphatase, farnesyl diphosphatase, FDPase, geranylgeranyl diphosphatase, GGDPase, More, prenol pyrophosphatase, prenol pyrophosphate pyrophosphohydrolase, prenol-pyrophosphatase, prenyl-pyrophosphatase, prenylphosphatase

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.7 Diphosphoric-monoester hydrolases

                3.1.7.1 prenyl-diphosphatase

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Results	in table
5	Activating Compound
11	AA Sequence
1	CAS Registry Number
28	Inhibitors
2	KM Value [mM]
5	Localization
3	Metals/Ions
3	Natural Substrates/ Products (Substrates)
4	Organism
8	pH Optimum
2	Purification (Commentary)
1	Reaction
1	Reaction Type
4	Reference
8	Source Tissue
2	Specific Activity [micromol/min/mg]
3	Storage Stability
22	Substrates and Products (Substrate)
13	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Inhibitors

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Inhibitors on EC 3.1.7.1 - prenyl-diphosphatase

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INHIBITOR

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

IMAGE

1-butanol

Rattus norvegicus

-

-

95169

3',5'-cAMP

Rattus norvegicus

-

-

95169

5,5'-dithiobis-(2-nitrobenzoic acid)

Citrus sinensis

-

-

95168

arsenite

Rattus norvegicus

-

-

95169

ATP

Citrus sinensis

-

inhibits NPP and GPP hydrolysis

95168

Ca2+

Citrus sinensis

-

decreases the rate of hydrolysis of several substrates at higher concentrations

95168

Co2+

Rattus norvegicus

-

-

95169

Cu2+

Rattus norvegicus

-

-

95169

dimethylallyl diphosphate

Rattus norvegicus

-

-

95169

EDTA

Citrus sinensis

-

-

95168

farnesoic acid

Rattus norvegicus

-

-

95169

farnesyl diphosphate

Oryza sativa

-

GGDPase activity, 0.1 mM, 50% inhibition

656974

geranyl diphosphate

2 entries

geranylgeranyl diphosphate

2 entries

isopentenyl diphosphate

2 entries

Mg2+

2 entries

Mn2+

2 entries

NaF

Rattus norvegicus

-

-

95169

phosphate

Citrus sinensis

-

inhibits NPP and GPP hydrolysis

95168

Plasma albumin

Rattus norvegicus

-

-

95169

-

Zn2+

Rattus norvegicus

-

-

95169

additional information

2 entries

-

geranyl diphosphate

Datura stramonium

-

0.1 mM: 16% inhibition of soluble FDPase activity, 0.05 mM: 26% inhibition of microsomal FDPase activity, competitive

654930

geranyl diphosphate

Oryza sativa

-

FDPase activity, 0.1 mM, 50% inhibition, no inhibition of GGDPase

656974

geranylgeranyl diphosphate

Datura stramonium

-

0.05 mM, 16% inhibition of soluble and 38% inhibition of microsomal FDPase activity, competitive

654930

geranylgeranyl diphosphate

Oryza sativa

-

FDPase activity, 0.005 mM, 50% inhibition

656974

isopentenyl diphosphate

Oryza sativa

-

GGDPase activity, 0.05 mM, 50% inhibition

656974

isopentenyl diphosphate

Rattus norvegicus

-

-

95169

Mg2+

Citrus sinensis

-

decreases the rate of hydrolysis of several substrates at higher concentrations

95168

Mg2+

Rattus norvegicus

-

loss of about 88% of activity at 10 mM

95169

Mn2+

Citrus sinensis

-

decreases the rate of hydrolysis of several substrates at higher concentrations

95168

Mn2+

Rattus norvegicus

-

-

95169

additional information

Datura stramonium

-

not inhibited by ATP or p-nitrophenyl phosphate

654930

-

additional information

Rattus norvegicus

-

-

95169

-