3.1.6.9: chondro-4-sulfatase
This is an abbreviated version!
For detailed information about chondro-4-sulfatase, go to the full flat file.
Word Map on EC 3.1.6.9
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3.1.6.9
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chondroitinase
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chondro-6-sulfatase
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cartilage
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disaccharide
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hyaluronidase
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proteoglycans
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dermatan
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desulfation
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pronase
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shark
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35ssulfate
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tetrasaccharide
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sulfate-protein
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flavobacterium
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monosulfated
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squid
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n-acetylgalactosamine
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xyl
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galnac
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heparinum
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beta-eliminated
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4-o-sulfate
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sulfatases
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analysis
- 3.1.6.9
- chondroitinase
- chondro-6-sulfatase
- cartilage
- disaccharide
- hyaluronidase
- proteoglycans
- dermatan
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desulfation
- pronase
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shark
-
35ssulfate
- tetrasaccharide
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sulfate-protein
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flavobacterium
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monosulfated
- squid
- n-acetylgalactosamine
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xyl
- galnac
- heparinum
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beta-eliminated
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4-o-sulfate
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sulfatases
- analysis
Reaction
Synonyms
chondroitin-4-sulfatase, sulfatase, chondro-4-
ECTree
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Substrates Products
Substrates Products on EC 3.1.6.9 - chondro-4-sulfatase
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REACTION DIAGRAM
4-deoxy-alpha-L-threo-hex-4-enepyranosyluronic acid-beta-(1-3)-GalNAc4SO3--beta-(1-4)-glucuronic acid-2-sulfate-beta-(1-3)-GalNAc6SO3-beta-(1-4)-glucuronic acid-beta-(1-3)-GalNAc4SO3- + H2O
sulfate + 4-deoxy-alpha-L-threo-hex-4-enepyranosyluronic acid-beta-(1-3)-GalNAc-beta-(1-4)-glucuronic acid-2-sulfate-beta-(1-3)-GalNAc6SO3-beta-(1-4)-glucuronic acid-beta-(1-3)-GalNAc
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removal of two sulfate groups
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?
4-deoxy-alpha-L-threo-hex-4-enepyranosyluronic acid-beta-(1-3)-GalNAc6SO3--beta-(1-4)-glucuronic acid-beta-(1-3)-GalNAc4SO3-beta-(1-4)-glucuronic acid-beta-(1-3)-GalNAc4SO3- + H2O
sulfate + 4-deoxy-alpha-L-threo-hex-4-enepyranosyluronic acid-beta-(1-3)-GalNAc6SO3--beta-(1-4)-glucuronic acid-beta-(1-3)-GalNAc-beta-(1-4)-glucuronic acid-beta-(1-3)-GalNAc
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removal of two sulfate groups
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?
4-deoxy-alpha-L-threo-hex-4-enepyranosyluronic acid-beta-(1-3)-GalNAc6SO3-beta-(1-4)-glucuronic acid-beta-(1-3)-GalNAc6SO3-beta-(1-4)-glucuronic acid-beta-(1-3)-GalNAc4SO3- + H2O
sulfate + 4-deoxy-alpha-L-threo-hex-4-enepyranosyluronic acid-beta-(1-3)-GalNAc6SO3-beta-(1-4)-glucuronic acid-beta-(1-3)-GalNAc6SO3-beta-(1-4)-glucuronic acid-beta-(1-3)-GalNAc
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removal of one sulfate group
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?
4-deoxy-alpha-L-threo-hex-4-enepyranosyluronic acid2SO3--beta-(1-3)-GalNAc6SO3--beta-(1-4)-glucuronic acid-beta-(1-3)-GalNAc4SO3-beta-(1-4)-glucuronic acid-beta-(1-3)-GalNAc4SO3- + H2O
sulfate + 4-deoxy-alpha-L-threo-hex-4-enepyranosyluronic acid2SO3--beta-(1-3)-GalNAc6SO3--beta-(1-4)-glucuronic acid-beta-(1-3)-GalNAc-beta-(1-4)-glucuronic acid-beta-(1-3)-GalNAc
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removal of two sulfate groups
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?
4-deoxy-alpha-L-threo-hex-4-enepyranosyluronic acid2SO3--beta-(1-3)-GalNAc6SO3--beta-(1-4)-glucuronic acid-beta-(1-3)-GalNAc6SO3-beta-(1-4)-glucuronic acid-beta-(1-3)-GalNAc4SO3- + H2O
sulfate + 4-deoxy-alpha-L-threo-hex-4-enepyranosyluronic acid2SO3--beta-(1-3)-GalNAc6SO3--beta-(1-4)-glucuronic acid-beta-(1-3)-GalNAc6SO3-beta-(1-4)-glucuronic acid-beta-(1-3)-GalNAc
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removal of one sulfate group
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?
4-deoxy-alpha-L-threo-hex-4-enepyranuronosyl-(1->3)-beta-D-GalNAc(4-O-sulfate)-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal(4-O-sulfate)-(1->3)-beta-D-Gal-(1->4)-D-Xyl + H2O
sulfate + 4-deoxy-alpha-L-threo-hex-4-enepyranuronosyl-(1->3)-beta-D-GalNAc-(1->4)-beta-D-GlcA-(1->3)-beta-D-Gal-(1->3)-beta-D-Gal-(1->4)-D-Xyl
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the enzyme breaks down one of the products of the chondroitin lyase reaction. An upstream insertion mutant that has no detectable chondro-4-sulfatase activity is still able to grow on chondroitin sulfate, although the rate is slower than that of the wild type
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additional information
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the enzyme acts preferentially on an ester sulfate on the C4 position of the GalNAc residue at the reducing end under mild incubation conditions, but also releases a sulfate group under harsh conditions from the C4 position of the GalNAc residue at the internal positions of the hexasaccharide chains, unless the GalNAc residue has another ester sulfate on its C6 position
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