3.1.6.14: N-acetylglucosamine-6-sulfatase

This is an abbreviated version, for detailed information about N-acetylglucosamine-6-sulfatase, go to the full flat file.

Reaction

hydrolysis of the 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate =

Synonyms

2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase, 6-O-sulfatase, acetylglucosamine 6-sulfatase, chondroitinsulfatase, G6S, glucosamine 6-O-sulfatase, glucosamine-6-sulfatase, glucosamine-6-sulfate sulfatase, heparin/heparan sulfate 6-O-sulfatase, HSGAG sulfatase, N-acetylglucosamine 6-sulfate sulfatase, N-acetylglucosamine-6-sulfatase, NG6S, O,N-disulfid O-sulfohydrolase, sulfatase, acetylglucosamine 6-

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.6 Sulfuric-ester hydrolases
                3.1.6.14 N-acetylglucosamine-6-sulfatase

Disease

Disease on EC 3.1.6.14 - N-acetylglucosamine-6-sulfatase

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DISEASE
TITLE OF PUBLICATION
LINK TO PUBMED
arylsulfatase deficiency
A screening method for mucopolysaccharidoses with increased urinary excretion of sulfated N-acetylhexosamines.
Lysosomal Storage Diseases
Caprine mucopolysaccharidosis IIID: fetal and neonatal brain and liver glycosaminoglycan and morphological perturbations.
Mucopolysaccharidosis III (Sanfilippo Syndrome)- disease presentation and experimental therapies.
Update of the spectrum of mucopolysaccharidoses type III in Tunisia: identification of three novel mutations and in silico structural analysis of the missense mutations.
Mucopolysaccharidoses
Caprine mucopolysaccharidosis IIID: a preliminary trial of enzyme replacement therapy.
Caprine mucopolysaccharidosis IIID: fetal and neonatal brain and liver glycosaminoglycan and morphological perturbations.
Diagnosis of caprine mucopolysaccharidosis type IIID by real-time polymerase chain reaction-based genotyping.
Genomic basis of mucopolysaccharidosis type IIID (MIM 252940) revealed by sequencing of GNS encoding N-acetylglucosamine-6-sulfatase.
Human glucosamine-6-sulfatase cDNA reveals homology with steroid sulfatase.
Mucopolysaccharidosis III (Sanfilippo Syndrome)- disease presentation and experimental therapies.
Sanfilippo D syndrome: estimation of N-acetylglucosamine-6-sulfatase activity with a radiolabeled monosulfated disaccharide substrate.
Sanfilippo syndrome type D: natural history and identification of 3 novel mutations in the GNS Gene.
Update of the spectrum of mucopolysaccharidoses type III in Tunisia: identification of three novel mutations and in silico structural analysis of the missense mutations.
Mucopolysaccharidosis III
A screening method for mucopolysaccharidoses with increased urinary excretion of sulfated N-acetylhexosamines.
Caprine mucopolysaccharidosis IIID: a preliminary trial of enzyme replacement therapy.
Diagnosis of caprine mucopolysaccharidosis type IIID by real-time polymerase chain reaction-based genotyping.
Genomic basis of mucopolysaccharidosis type IIID (MIM 252940) revealed by sequencing of GNS encoding N-acetylglucosamine-6-sulfatase.
Human glucosamine-6-sulfatase cDNA reveals homology with steroid sulfatase.
Molecular characterization of MPS IIIA, MPS IIIB and MPS IIIC in Tunisian patients.
Mucopolysaccharidosis III (Sanfilippo Syndrome)- disease presentation and experimental therapies.
Recombinant caprine 3H-[N-acetylglucosamine-6-sulfatase] and human 3H-[N-acetylgalactosamine-4-sulfatase]: plasma clearance, tissue distribution, and cellular uptake in the rat.
Sanfilippo D syndrome: estimation of N-acetylglucosamine-6-sulfatase activity with a radiolabeled monosulfated disaccharide substrate.
Sanfilippo syndrome type D: natural history and identification of 3 novel mutations in the GNS Gene.
Sanfilippo syndrome, type D: a spectrophotometric assay with prenatal diagnostic potential.
Multiple Sulfatase Deficiency Disease
A screening method for mucopolysaccharidoses with increased urinary excretion of sulfated N-acetylhexosamines.