3.1.6.13: iduronate-2-sulfatase
This is an abbreviated version!
For detailed information about iduronate-2-sulfatase, go to the full flat file.
Word Map on EC 3.1.6.13
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3.1.6.13
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mucopolysaccharidosis
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lysosomal
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glycosaminoglycans
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x-linked
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dermatan
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heparan
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multisystemic
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sulfatases
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hepatosplenomegaly
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medicine
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arylsulfatase
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mpsii
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x-chromosome
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enzyme-replacement
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analysis
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synthesis
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alpha-l-iduronidase
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neuronopathic
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infusion-related
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drug development
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6-minute
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dysostosis
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diagnostics
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shire
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hurler
- 3.1.6.13
- mucopolysaccharidosis
- lysosomal
- glycosaminoglycans
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x-linked
- dermatan
- heparan
-
multisystemic
-
sulfatases
-
hepatosplenomegaly
- medicine
- arylsulfatase
-
mpsii
-
x-chromosome
-
enzyme-replacement
- analysis
- synthesis
- alpha-l-iduronidase
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neuronopathic
-
infusion-related
- drug development
-
6-minute
- dysostosis
- diagnostics
-
shire
- hurler
Reaction
Synonyms
2-sulfo-L-iduronate 2-sulfatase, chondroitinsulfatase, elaprase, Hunter corrective factor, I2S, IDS, IDS-Like, IDS-like enzyme, iduronate 2-sulfatase, iduronate 2-sulfate sulfatase-like, iduronate 2-sulfate-like enzyme, iduronate sulfatase, iduronate sulfate sulfatase, iduronate-2-sulfatase, iduronate-2-sulfate sulfatase, iduronate-2-sulphatase, iduronide-2-sulfate sulfatase, idurono-2-sulfatase, idursulfase, L-iduronate 2-sulfate sulfatase, L-idurono sulfate sulfatase, sulfatase, L-idurono-, sulfo-L-iduronate sulfatase, sulfoiduronate sulfohydrolase
ECTree
3.1.6.13 iduronate-2-sulfataseAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.1.6.13 - iduronate-2-sulfatase
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
dermatan sulfate + H2O
dermatan + sulfate
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?
heparan sulfate + H2O
dermatan + sulfate
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?
heparin + H2O
desulfated heparin + sulfate
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?
additional information
?
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the enzyme is involved in the catabolism of the mucopolysaccharides heparan and dermatan sulfate
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?
additional information
?
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the enzyme is involved in the sequential degradation of the glycosaminoglycans heparan sulfate and dermatan sulfate
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?
additional information
?
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the enzyme is responsible for heparin sulfate and dermatan sulfate degradation
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?
additional information
?
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the enzyme is responsible for heparin sulfate and dermatan sulfate degradation
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?
additional information
?
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involved in the degradation of the glycosaminoglycans heparan sulfate and dermatan sulfate. An enzyme deficiency causes the lysosomal storage disorder muco-polysaccharidosis type II
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?
additional information
?
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involved in the degradation of the glycosaminoglycans heparan sulfate and dermatan sulfate. An enzyme deficiency causes the lysosomal storage disorder muco-polysaccharidosis type II
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?
additional information
?
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mucopolysaccharidosis type II is a lysosomal storage disorder related to a deficiency in the enzyme iduronate-2-sulfatase
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?
additional information
?
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The enzyme has a potential role in normal pathway of lysosomal degradation of secretory peptides and is likely to be essential to maintain pancreatic beta-cell function
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?
additional information
?
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the enzyme is involved in the catabolism of the mucopolysaccharides heparan and dermatan sulfate
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?
