3.1.5.B1: dNTPase
This is an abbreviated version!
For detailed information about dNTPase, go to the full flat file.
Word Map on EC 3.1.5.B1
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3.1.5.B1
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myeloid
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dntps
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domain-containing
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viruses
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dendritic
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lentiviruses
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retroviral
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simian
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retroviruses
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deoxynucleotide
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histidine-aspartate
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monocyte-derived
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vpx-mediated
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vpr
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antiretroviral
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deoxyribonucleoside
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sivmac
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apobec3g
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non-cycling
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non-dividing
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anti-hiv-1
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tetherin
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chilblain
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line-1
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aicardi-goutieres
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rnaseh2a
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interferon-stimulated
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retrotransposition
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interferonopathy
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cytarabine
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sivsm
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mddcs
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medicine
-
analysis
- 3.1.5.B1
- myeloid
- dntps
-
domain-containing
- viruses
- dendritic
- lentiviruses
-
retroviral
-
simian
- retroviruses
- deoxynucleotide
-
histidine-aspartate
-
monocyte-derived
-
vpx-mediated
- vpr
-
antiretroviral
- deoxyribonucleoside
-
sivmac
- apobec3g
-
non-cycling
-
non-dividing
-
anti-hiv-1
-
tetherin
-
chilblain
-
line-1
-
aicardi-goutieres
- rnaseh2a
-
interferon-stimulated
-
retrotransposition
-
interferonopathy
- cytarabine
-
sivsm
-
mddcs
- medicine
- analysis
Reaction
Synonyms
deoxynucleoside triphosphate triphosphohydrolase, deoxyribonucleotide triphosphohydrolase, EF_1143, HD domain protein, SAMHD1
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3.1.5.B1 dNTPaseAdvanced search results
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Substrates Products on EC 3.1.5.B1 - dNTPase
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SUBSTRATE 
PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
bis(4-nitrophenyl) phosphate + H2O
4-nitrophenyl phosphate + 4-nitrophenol
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?
additional information
?
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enzyme EF1143 fails to hydrolyze any of the dNTPs when a sole dNTP is present in the reaction mixture. Among the four dNTPs, only dGTP can function as an activator of dATP and dCTP hydrolysis. dGTP hydrolysis is clearly enhanced by the presence of dATP or dCTP, but not dTTP, with dATP being the more potent activator. Further, dTTP hydrolysis is virtually nonexistent when any one other dNTP is combined with dTTP in the reaction mixture. With all four dNTPs present at equal concentrations, the decreasing order of dNTP hydrolysis is dGTP, dCTP, dATP, dTTP
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?
additional information
?
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enzyme EF1143 fails to hydrolyze any of the dNTPs when a sole dNTP is present in the reaction mixture. Among the four dNTPs, only dGTP can function as an activator of dATP and dCTP hydrolysis. dGTP hydrolysis is clearly enhanced by the presence of dATP or dCTP, but not dTTP, with dATP being the more potent activator. Further, dTTP hydrolysis is virtually nonexistent when any one other dNTP is combined with dTTP in the reaction mixture. With all four dNTPs present at equal concentrations, the decreasing order of dNTP hydrolysis is dGTP, dCTP, dATP, dTTP
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?
additional information
?
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enzyme EF1143 fails to hydrolyze any of the dNTPs when a sole dNTP is present in the reaction mixture. Among the four dNTPs, only dGTP can function as an activator of dATP and dCTP hydrolysis. dGTP hydrolysis is clearly enhanced by the presence of dATP or dCTP, but not dTTP, with dATP being the more potent activator. Further, dTTP hydrolysis is virtually nonexistent when any one other dNTP is combined with dTTP in the reaction mixture. With all four dNTPs present at equal concentrations, the decreasing order of dNTP hydrolysis is dGTP, dCTP, dATP, dTTP
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?
