3.1.30.2: Serratia marcescens nuclease
This is an abbreviated version!
For detailed information about Serratia marcescens nuclease, go to the full flat file.
Word Map on EC 3.1.30.2
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3.1.30.2
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strand
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single-stranded
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nick
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chromatin
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exonuclease
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phage
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nucleases
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rnase
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bacteriophage
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endonucleolytic
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mismatch
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palindromic
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structure-specific
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internucleosomal
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homing
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glycosylase
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methylase
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phosphodiester
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fork
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restriction-modification
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interspaced
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supercoiled
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crispr
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heteroduplexes
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abasic
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deoxyribonuclease
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retrotransposons
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xeroderma
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aif
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caspase-independent
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dsdna
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pigmentosum
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ape1
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endoribonuclease
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holliday
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end-joining
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nucleolytic
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colicins
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ecorv
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retrotransposition
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interstrand
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okazaki
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mre11
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superhelical
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pvuii
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haeiii
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overhang
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cap-dependent
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sgrnas
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resolvase
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molecular biology
- 3.1.30.2
- strand
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single-stranded
- nick
- chromatin
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exonuclease
- phage
- nucleases
- rnase
- bacteriophage
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endonucleolytic
- mismatch
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palindromic
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structure-specific
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internucleosomal
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homing
- glycosylase
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methylase
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phosphodiester
- fork
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restriction-modification
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interspaced
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supercoiled
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crispr
- heteroduplexes
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abasic
- deoxyribonuclease
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retrotransposons
- xeroderma
- aif
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caspase-independent
- dsdna
- pigmentosum
- ape1
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endoribonuclease
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holliday
-
end-joining
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nucleolytic
- colicins
- ecorv
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retrotransposition
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interstrand
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okazaki
- mre11
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superhelical
- pvuii
- haeiii
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overhang
-
cap-dependent
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sgrnas
- resolvase
- molecular biology
Reaction
endonucleolytic cleavage to 5'-phosphomononucleotide and 5'-phosphooligonucleotide end-products =
Synonyms
barley nuclease, BFN1, BMN, CAD, caspase-activated DNase, DFF, DFF40/CAD endonuclease, DNA fragmentation factor, EC 3.1.4.9, ENDO1, ENDO2, ENDO4, ENDO5, endonuclease, endonuclease (Serratia marcescens), endonuclease 1, endonuclease 2, endonuclease 4, endonuclease 5, Kamchatka crab duplex-specific nuclease, More, mung bean nuclease, NUC49, nucA, NucANLS, nuclease A, nuclease I, nuclease, nucleate endo-, nucleate endonuclease, Par_DSN, plant nuclease I, plant S1-like nuclease, plant type I nuclease, rNUC49, S1-like nuclease, Serratia marcescens endonuclease, Serratia marcescens nuclease, Sm2, Sma, Sma nuc, Sma nuc endonuclease, SMnase
ECTree
3.1.30.2 Serratia marcescens nucleaseAdvanced search results
results (
results (Natural Substrates Products
Natural Substrates Products on EC 3.1.30.2 - Serratia marcescens nuclease
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
DNA + H2O
?
dsDNA to ssDNA preference ratio for Par_DSN-t4 is equal to 10, corresponding ratio for intact Par_DSN is equal to 1000
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?
DNA + H2O
?
protein and DNA are held together by a mix of salt-bridges, water-mediated and direct hydrogen bond interactions between the protein and DNA backbone, almost no DNA bases are directly involved in the contacts
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?
dsDNA + H2O
?
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primarily responsible for internucleosomal DNA cleavage during the terminal stages of apoptosis, preference for cleaving the internucleosomal linker regions in chromatin
fragments possessing ends with 5-phosphate and 3-hydroxyl groups, exclusively double strand breaks (primarily blunt ends)
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?
dsDNA + H2O
?
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DNA fragments carrying phosphate groups at 5' ends and hydroxyl group at the 3' ends
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?
dsDNA + H2O
?
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physiological function currently unknown
DNA fragments carrying phosphate groups at 5' ends and hydroxyl group at the 3' ends, random DNA cleavage with respect to all possible phosphodiester bonds
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?
additional information
?
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isozyme ENDO2 digests ssDNA over dsDNA, it achieves strong DNase activity under two completely different conditions, but it exerts its nuclease activity towards dsDNA only in acidic buffer as a Ca2+/Zn2+-dependent enzyme
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?
additional information
?
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isozyme ENDO2 digests ssDNA over dsDNA, it achieves strong DNase activity under two completely different conditions, but it exerts its nuclease activity towards dsDNA only in acidic buffer as a Ca2+/Zn2+-dependent enzyme
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?
additional information
?
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isozyme ENDO2 digests ssDNA over dsDNA, it achieves strong DNase activity under two completely different conditions, but it exerts its nuclease activity towards dsDNA only in acidic buffer as a Ca2+/Zn2+-dependent enzyme
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?
additional information
?
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isozyme ENDO2 digests ssDNA over dsDNA, it achieves strong DNase activity under two completely different conditions, but it exerts its nuclease activity towards dsDNA only in acidic buffer as a Ca2+/Zn2+-dependent enzyme
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?
additional information
?
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isozyme ENDO4 shows quite strong DNase activity, but relatively weak RNase activity
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?
additional information
?
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isozyme ENDO4 shows quite strong DNase activity, but relatively weak RNase activity
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?
additional information
?
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isozyme ENDO4 shows quite strong DNase activity, but relatively weak RNase activity
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?
additional information
?
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isozyme ENDO4 shows quite strong DNase activity, but relatively weak RNase activity
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?
additional information
?
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no activity by isozyme ENDO5 on ssDNA or dsDNA
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?
additional information
?
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no activity by isozyme ENDO5 on ssDNA or dsDNA
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?
additional information
?
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no activity by isozyme ENDO5 on ssDNA or dsDNA
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?
additional information
?
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no activity by isozyme ENDO5 on ssDNA or dsDNA
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?
additional information
?
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the isozyme ENDO1 is defined as bifunctional enzymes due to its ability to digest both DNA and RNA substrates, showing a quite strong DNase activity and weak RNase activity, it digests ssDNA over dsDNA
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?
additional information
?
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the isozyme ENDO1 is defined as bifunctional enzymes due to its ability to digest both DNA and RNA substrates, showing a quite strong DNase activity and weak RNase activity, it digests ssDNA over dsDNA
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?
additional information
?
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the isozyme ENDO1 is defined as bifunctional enzymes due to its ability to digest both DNA and RNA substrates, showing a quite strong DNase activity and weak RNase activity, it digests ssDNA over dsDNA
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?
additional information
?
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the isozyme ENDO1 is defined as bifunctional enzymes due to its ability to digest both DNA and RNA substrates, showing a quite strong DNase activity and weak RNase activity, it digests ssDNA over dsDNA
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?
additional information
?
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single-stranded DNA, single-stranded RNA, double-stranded RNA nor RNA-DNA heteroduplexes are not substrates for the enzyme
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?
additional information
?
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recombinant protein is active on plasmid DNA, circular recessed and flap M13 substrate with short protruding single strand
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?
additional information
?
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the enzyme potently degrades both DNA and RNA and is a nuclease with broad specificity, but it shows some sensitivity to the secondary structure of the substrate
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?
additional information
?
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substrate specificity in descending order is ssDNA, dsDNA, RNA
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?
additional information
?
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mung bean nuclease is an endonuclease specific to single-stranded DNA or RNA
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?
