3.1.26.7: ribonuclease P4

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For detailed information about ribonuclease P4, go to the full flat file.

Reaction

endonucleolytic cleavage of RNA, removing 3'-extranucleotides from tRNA precursor =

Synonyms

P4, ribonuclease P ribozyme, ribonuclease P RNA, RNase P, RNase P RNA, RNaseP P4

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.26 Endoribonucleases producing 5'-phosphomonoesters

                3.1.26.7 ribonuclease P4

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Results	in table
1	Activating Compound
1	CAS Registry Number
1	Inhibitors
3	KM Value [mM]
2	Localization
11	Metals/Ions
6	Natural Substrates/ Products (Substrates)
58	Organism
4	pH Optimum
3	Protein Variants
1	Purification (Commentary)
2	Reaction
2	Reaction Type
8	Reference
2	Source Tissue
12	Substrates and Products (Substrate)
2	Subunits
9	Synonyms
3	Temperature Optimum [°C]

Engineering

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Engineering on EC 3.1.26.7 - ribonuclease P4

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PROTEIN VARIANTS

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

additional information

3 entries

additional information

Escherichia coli

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construction of 2 self-cleaving ribozyme-substrate conjugates for identification of nucleotides involved in catalysis

657335

additional information

Escherichia coli

-

construction of a mutant enzymatically active enzyme P4 RNA ribozyme with altered metal ion specificity, preference for Ca2+ instead of Mg2+

657334

additional information

Escherichia coli

-

construction of ribozyme mutants with moved bulged nucleotides important for metal ion coordination, proximal or distal to metal coordination sites, the first has moderate but positive effect on catalysis and cleavage pattern, the latter has large, negative effects on catalysis and cleavage pattern, overview

656506