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3.1.26.4: ribonuclease H

This is an abbreviated version!
For detailed information about ribonuclease H, go to the full flat file.

Word Map on EC 3.1.26.4

Reaction

Endonucleolytic cleavage to a 5'-phosphomonoester =

Synonyms

Ape-RNase HII, aRNase HII, Bh ribonuclease H, BhRNase H, CtepRNH, EcRNH, endoribonuclease H, endoribonuclease H (calf thymus), ERNH, huRNaseH1, hybrid nuclease, hybrid ribonuclease, hybridase, hybridase (ribonuclease H), KOD1, LC9-RNase H1, lmo1273, LRNase HII, More, nuclease, hybrid ribo-, nuclease, ribo-, H, P32, protein ST0753, reverse transcriptase, ribonuclease H, ribonuclease H I, ribonuclease H(42), ribonuclease H(70), ribonuclease H1, ribonuclease H2, ribonuclease H3, ribonuclease HI, ribonuclease HII, ribonuclease HIII, ribonulease H1, RNA*DNA hybrid ribonucleotidohydrolase, RNA*DNA hybrid ribonucleotiohydrolase, RNase H, RNase H type 2, RNase H(35), RNase H1, RNase H2, RNase H3, RNase HI, RNase HII, RNase HIII, RNaseH, Rnaseh1, RNASEH2A, RNH, RNH1, RNH2, rnhA, RnhB, rnhC, rnhD, Rv2228c, ST0519, STK_07530, Sto-RNase HI, T4 RNase H, Tk-RNase HII, Tk-Tk-RNase HII, TK0805, TRNH, TthRNH, Ty1 reverse transcriptase/RNase H, type 1 ribonuclease H, type 1 RNase H, type 2 ribonuclease H, type 2 RNase H, type II ribonuclease H

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.26 Endoribonucleases producing 5'-phosphomonoesters
                3.1.26.4 ribonuclease H

pH Range

pH Range on EC 3.1.26.4 - ribonuclease H

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pH RANGE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
6 - 10
the cleavage activity increases exponentially as the pH increases from 6 to 10
6 - 11
the enzyme exhibits approximately 80% of the maximal activity at pH 8.5
6.5 - 11
-
more than 60% activity at pH 6.5, about 70% activity at pH 7.0, maximum activity at pH 7.5, more than 80% activity between pH 8.0 and 11.0
6.5 - 8
6.8 - 8.4
-
pH 6.8: about 60% of maximal activity, pH 8.4: about 35% of maximal activity, enzyme form H-2
6.9 - 9.1
-
pH 6.9: 50% of maximal activity, pH 7.5-9.1: optimum
7 - 10.5
-
pH 7.0: about 50% of maximal activity, pH 10.5: about 60% of maximal activity
7 - 11
the enzyme exhibits approximately 20-30% of maximal activity at pH 7.0 and 11.0
7 - 9.8
-
enzyme is inactive below pH 7.0, activity increases with increasing pH
7.1 - 12
7.5 - 10
activity range dependent on cation added
7.5 - 9
-
about 45% of maximal activity at pH 7.5 and at pH 9.0, enzyme form H-1
additional information
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