3.1.26.3: ribonuclease III

This is an abbreviated version!
For detailed information about ribonuclease III, go to the full flat file.

Reaction

Endonucleolytic cleavage to a 5'-phosphomonoester =

Synonyms

Aa-RNase III, AbsB, At1g55140, At3g13740, AtRTL1, AtRTL2, AtRTL3, BB_0705, BCG-RNase III, Bm-RNase III, cgR_1959, class 1 RNase III, DCL1, DCL2, DCL3, DCL4, DCR-1, Dicer, Dicer 1, Dicer-1, Dicer-2, Dicer1, double strand-specific endoRNase, Drosha, dsRNA-specific class 1 RNase III-like endoribonuclease, E. coli RNase III, Ec-RNase III, endoribonuclease III, endoribonucleases III, exodeoxyribonuclease III, HCS protein, Hs-Dicer, Hs-Drosha, KREPB10, KREPB9, Lac-RNase III, mini-III, mitochondrial RNA precursor-processing endonuclease 1, More, mRPN1, nuclease, ribo-, D, p241, Pac1p, RBIV RNase III, ribonuclease D, ribonuclease III, ribonuclease III-like protein, ribonuclease type III, RNase D, RNase G, RNase III, RNase III domain A, RNase III double-stranded RNA endonuclease, RNase III endonuclease, RNase III-like protein, RNase O, RNase3, rnc, RNC1, RNC3, RNC4, rncS, RNT1, Rnt1p, Rnt1p RNase III, Sa-RNase III, Sc-Rnt1p, SmRNase III, Tb09.160.3050, Tb927.8.5700, Tm-RNase III, TNase III

ECTree

     3 Hydrolases

         3.1 Acting on ester bonds

             3.1.26 Endoribonucleases producing 5'-phosphomonoesters

                3.1.26.3 ribonuclease III

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Results	in table
21	Activating Compound
40761	AA Sequence
1	Application
1	CAS Registry Number
62	Cloned(Commentary)
19	Crystallization (Commentary)
5595	Disease/ Diagnostics
4	Expression
188	General Information
1	IC50 Value
65	Inhibitors
7	kcat/KM [mM/s]
1	Ki Value [mM]
33	KM Value [mM]
19	Localization
187	Metals/Ions
29	Molecular Weight [Da]
184	Natural Substrates/ Products (Substrates)
266	Organism
102	PDB ID
33	pH Optimum
7	pH Range
4	Posttranslational Modification
133	Protein Variants
56	Purification (Commentary)
23	Reaction
14	Reaction Type
219	Reference
1	Renatured (Commentary)
31	Source Tissue
3	Specific Activity [micromol/min/mg]
4	Storage Stability
447	Substrates and Products (Substrate)
69	Subunits
342	Synonyms
29	Temperature Optimum [°C]
6	Temperature Range [°C]
6	Temperature Stability [°C]
23	Turnover Number [1/s]

Expression

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Expression on EC 3.1.26.3 - ribonuclease III

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EXPRESSION

ORGANISM

UNIPROT

LITERATURE

Micro-dicer siRNAs-1 to -3 elicit percentage transcript increases of 775, 1832 and 645, respectively

Meloidogyne incognita

-

708793

Micro-drosha siRNAs-1 to -3 yield a very highly significant level of target transcript knockdown compared with the control siRNA following egg-stage soaks, with a mean 88.1%, 98.6%, and 99.89% decrease, respectively. Soaking the J2s in dicer siRNA results in a modest decrease in dicer transcript abundance

Meloidogyne incognita

-

708793

the Ascovirus-encoded RNase III autoregulates its expression and suppresses RNA interference-mediated gene silencing

Heliothis virescens ascovirus 3e

-

716063

the RNase III operon includes the rnc and era genes encoding RNase III and Era proteins, respectively. RNase III cleaves its own leader RNA, causing instability of its mRNA. Thus, RNase III can repress its own synthesis and also that of Era, because era is transcriptionally and translationally coupled to rnc expression. Era function is critical for maintaining cell growth and cell division rate in Escherichia coli, so that the regulation of Era levels by RNase III has been proposed as an important feature of the Escherichia coli cell cycle

Escherichia coli

P0A7Y0

751291