3.1.26.13: retroviral ribonuclease H

This is an abbreviated version!
For detailed information about retroviral ribonuclease H, go to the full flat file.

Word Map on EC 3.1.26.13

3.1.26.13

integrase

hiv-rt

rna-dna

template-primer

moloney

polypurine

transcriptases

minus-strand

3'-azido-3'-deoxythymidine

nnrti

primer-template

nonnucleoside

drug development

medicine

analysis

pharmacology

Reaction

Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. =

Synonyms

HIV reverse transcriptase ribonuclease H, HIV reverse transcriptase-associated RNase H, HIV RNase H, HIV RT RNaseH, HIV RT-associated RNase H, HIV-1 reverse transcriptase, HIV-1 reverse transcriptase ribonuclease H, HIV-1 reverse transcriptase RNase H, HIV-1 RH, HIV-1 ribonuclease H, HIV-1 ribonuclease H domain, HIV-1 RNase H, HIV-1 RT-associated RNase H, human immunodeficiency virus reverse transcriptase, human immunodeficiency virus reverse transcriptase-associated ribonuclease H, human immunodeficiency virus reverse transcriptase-associated RNase H, human immunodeficiency virus RT-associated RNase H, M-MuLV RT RNase H, reverse transcriptase, reverse transcriptase-associated ribonuclease H, reverse transcriptase-associated RNase H, reverse-transcriptase-associated ribonuclease H, ribonuclease H, ribonuclease H domain in HIV-1 reverse transcriptase, RNase H, RNase H activity of HIV-1 reverse transcriptase, RNase H domain of HIV-1 reverse transcriptase, RNase H of HIV-1 subtype C, RNaseH, RNH, RNHHIV, RT RNase H, RT-RNase H

Results	in table
3	Activating Compound
80	AA Sequence
11	Application
1	CAS Registry Number
21	Cloned(Commentary)
14	Crystallization (Commentary)
56	General Information
517	IC50 Value
556	Inhibitors
7	kcat/KM [mM/s]
3	Ki Value [mM]
20	KM Value [mM]
48	Metals/Ions
4	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
136	Organism
388	PDB ID
22	pH Optimum
2	Posttranslational Modification
291	Protein Variants
14	Purification (Commentary)
2	Reaction
120	Reference
1	Renatured (Commentary)
3	Source Tissue
3	Specific Activity [micromol/min/mg]
85	Substrates and Products (Substrate)
11	Subunits
154	Synonyms
20	Temperature Optimum [°C]
18	Temperature Stability [°C]
13	Turnover Number [1/s]

3.1.26.13: retroviral ribonuclease H

Reaction

Synonyms

ECTree

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Synonyms

Synonyms on EC 3.1.26.13 - retroviral ribonuclease H