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3.1.26.13: retroviral ribonuclease H

This is an abbreviated version!
For detailed information about retroviral ribonuclease H, go to the full flat file.

Word Map on EC 3.1.26.13

Reaction

Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. =

Synonyms

HIV reverse transcriptase ribonuclease H, HIV reverse transcriptase-associated RNase H, HIV RNase H, HIV RT RNaseH, HIV RT-associated RNase H, HIV-1 reverse transcriptase, HIV-1 reverse transcriptase ribonuclease H, HIV-1 reverse transcriptase RNase H, HIV-1 RH, HIV-1 ribonuclease H, HIV-1 ribonuclease H domain, HIV-1 RNase H, HIV-1 RT-associated RNase H, human immunodeficiency virus reverse transcriptase, human immunodeficiency virus reverse transcriptase-associated ribonuclease H, human immunodeficiency virus reverse transcriptase-associated RNase H, human immunodeficiency virus RT-associated RNase H, M-MuLV RT RNase H, reverse transcriptase, reverse transcriptase-associated ribonuclease H, reverse transcriptase-associated RNase H, reverse-transcriptase-associated ribonuclease H, ribonuclease H, ribonuclease H domain in HIV-1 reverse transcriptase, RNase H, RNase H activity of HIV-1 reverse transcriptase, RNase H domain of HIV-1 reverse transcriptase, RNase H of HIV-1 subtype C, RNaseH, RNH, RNHHIV, RT RNase H, RT-RNase H

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.26 Endoribonucleases producing 5'-phosphomonoesters
                3.1.26.13 retroviral ribonuclease H

IC50 Value

IC50 Value on EC 3.1.26.13 - retroviral ribonuclease H

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IC50 VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00051
(2S)-5,7-dihydroxy-2-(2-hydroxy-1-(phenylsulfonyl)propan-2-yl)-9-methyl-3,4-dihydro-1H-benzo[7]annulen-6(2H)-one
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.0193
(5E)-6-[1-(2,4-dimethylbenzyl)-1H-pyrrol-2-yl]-2,4-dioxohex-5-enoic acid
Human immunodeficiency virus 1
-
at pH 7.8 and 37°C
0.0192
(5E)-6-[1-(2-chlorobenzyl)-1H-pyrrol-2-yl]-2,4-dioxohex-5-enoic acid
Human immunodeficiency virus 1
-
at pH 7.8 and 37°C
0.087
(5E)-6-[1-(3-methoxybenzyl)-1H-pyrrol-2-yl]-2,4-dioxohex-5-enoic acid
Human immunodeficiency virus 1
-
at pH 7.8 and 37°C
0.0161
(5E)-6-[1-(4-fluorobenzyl)-1H-pyrrol-2-yl]-2,4-dioxohex-5-enoic acid
Human immunodeficiency virus 1
-
at pH 7.8 and 37°C
0.028
(5E)-6-[1-(4-fluorobenzyl)-1H-pyrrol-3-yl]-2,4-dioxohex-5-enoic acid
Human immunodeficiency virus 1
-
at pH 7.8 and 37°C
0.0077
(5E)-6-[1-(4-fluorobenzyl)-4-phenyl-1H-pyrrol-3-yl]-2,4-dioxohex-5-enoic acid
Human immunodeficiency virus 1
-
at pH 7.8 and 37°C
0.075
1,6,8-trihydroxy-3-methylanthraquinone
Human immunodeficiency virus 1
-
-
0.013
1,6-bis[(4-fluorophenyl)methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.015
1,6-dibenzyl-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0008
1-(3-[[(4-benzyl-5-methyl-4H-1,2,4-triazol-3-yl)sulfanyl]methyl]-4-methoxyphenyl)ethanone
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0021
1-(ethoxymethyl)-3-hydroxy-6-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.025
1-(ethoxymethyl)-6-[(4-fluorophenyl)methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
above, pH and temperature not specified in the publication
0.01
1-benzyl-6-[(4-fluorophenyl)methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0002
1-hydroxy-4-((4-(morpholinomethyl)phenyl)amino)pyrido[2,3-d]pyrimidin-2(1H)-one
Human immunodeficiency virus 1
-
in 50 mM Tris, pH 8.0, 80 mM KCl, 10 mM MgCl2, at 22°C
0.000079
1-hydroxy-4-((4-(pyridin-4-yl)phenyl)amino)pyrido[2,3-d]pyrimidin-2(1H)-one
Human immunodeficiency virus 1
-
in 50 mM Tris, pH 8.0, 80 mM KCl, 10 mM MgCl2, at 22°C
0.0002
1-hydroxy-4-([[3-(4-morpholinyl)phenyl]methyl]amino)pyrido[2,3-d]pyrimidin-2(1H)-one
Human immunodeficiency virus 1
-
in 50 mM Tris, pH 8.0, 80 mM KCl, 10 mM MgCl2, at 22°C
0.000398
1-hydroxy-4-([[3-(4-morpholinylmethyl)phenyl]methyl]amino)pyrido[2,3-d]pyrimidin-2(1H)-one
Human immunodeficiency virus 1
-
in 50 mM Tris, pH 8.0, 80 mM KCl, 10 mM MgCl2, at 22°C
0.0001
1-hydroxy-4-([[4-(4-morpholinyl)phenyl]methyl]amino)pyrido[2,3-d]pyrimidin-2(1H)-one
Human immunodeficiency virus 1
-
in 50 mM Tris, pH 8.0, 80 mM KCl, 10 mM MgCl2, at 22°C
0.000016
1-hydroxy-4-([[4-(4-pyridinyl)phenyl]methyl]amino)pyrido[2,3-d]pyrimidin-2(1H)-one
Human immunodeficiency virus 1
-
in 50 mM Tris, pH 8.0, 80 mM KCl, 10 mM MgCl2, at 22°C
0.0007
1-hydroxy-4-[4-(quinolin-3-yl)anilino]pyrido[2,3-d]pyrimidin-2(1H)-one
0.00005
1-hydroxy-4-[[4-(4-morpholinyl)phenyl]amino]pyrido[2,3-d]pyrimidin-2(1H)-one
Human immunodeficiency virus 1
-
in 50 mM Tris, pH 8.0, 80 mM KCl, 10 mM MgCl2, at 22°C
0.000003
1-hydroxy-4-[[4-(quinolin-3-yl)phenyl]amino]pyrido[2,3-d]pyrimidin-2(1H)-one
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0062
1-[[(4-fluorophenyl)methoxy]methyl]-6-[(4-fluorophenyl)methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.04
2'-deoxy-2'-fluoro-P-thioadenylyl-(3'->5')-N-naphthalen-1-ylguanosine
Human immunodeficiency virus 1
-
-
0.04
2'-deoxy-2'-fluoro-P-thioadenylyl-(3'->5')-N-[2-(4-nitrophenyl)ethyl]guanosine
Human immunodeficiency virus 1
-
-
0.0215
2,6-dimethoxy-N-(3-(pyridin-2-ylcarbamoyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)nicotinamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.0006
2,7-dihydroxy-4-(propan-2-yl)cyclohepta-2,4,6-trien-1-one
Human immunodeficiency virus 1
-
-
0.0019
2-(1,2-dihydroxy-1-methyl-ethyl)-5,7-dihydroxy-9-methyl-1,2,3,4-tetrahydrobenzocyclohepten-6-one
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.00096
2-(1-benzylamino-ethyl)-5,7-dihydroxy-9-methyl-1,2,3,4-tetrahydrobenzocyclohepten-6-one
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.0061
2-(2,3-dihydro-1H-inden-1-ylamino)-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.0055
2-(2,3-dihydro-1H-inden-2-ylamino)-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.01224
2-(2,4-dichlorobenzamido)-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.0099
2-(2-(2-fluorophenyl)acetamido)-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.01488
2-(2-aminobenzamido)-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.0013
2-(2-benzylsulfanyl-1-hydroxy-1-methyl-ethyl)-5,7-dihydroxy-9-methyl-1,2,3,4-tetrahydrobenzocyclohepten-6-one
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.00457
2-(2-bromobenzamido)-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.0075
2-(2-chloro-4-fluorobenzamido)-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.0239
2-(2-chlorobenzamido)-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.0671
2-(2-cyclohexylacetamido)-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.0005
2-(2-diethylamino-1-hydroxy-1-methyl-ethyl)-5,7-dihydroxy-9-methyl-1,2,3,4-tetrahydrobenzocyclohepten-6-one
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.00024
2-(2-ethanesulfonyl-1-hydroxy-1-methyl-ethyl)-5,7-dihydroxy-9-methyl-1,2,3,4-tetrahydrobenzocyclohepten-6-one
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.00038
2-(2-ethylsulfanyl-1-hydroxy-1-methyl-ethyl)-5,7-dihydroxy-9-methyl-1,2,3,4-tetrahydrobenzocyclohepten-6-one
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.01373
2-(2-fluorobenzamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.1
2-(2-fluorobenzamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylic acid
Human immunodeficiency virus type 1 group M subtype B
above, pH 7.8, 37°C
0.02189
2-(2-fluorobenzamido)-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.01425
2-(2-methoxybenzamido)-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.0183
2-(2-methylbenzamido)-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.05348
2-(2-nitrobenzamido)-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.0012
2-(3,4-dichlorobenzyl)-5,6-dihydroxypyrimidine-4-carboxylic acid
Human immunodeficiency virus 1
-
-
0.00084
2-(3,4-dihydroxybenzamido)-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.00401
2-(3,4-dimethoxybenzamido)-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.0037
2-(3,5-dimethylphenyl)-2-(3-(ethoxymethyl)-1-hydroxy-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)acetonitrile
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0009
2-(3-bromo-4-methoxybenzyl)-5,6-dihydroxypyrimidine-4-carboxylic acid
Human immunodeficiency virus 1
-
-
0.02047
2-(3-fluorobenzamido)-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.0146
2-(3-phenylpropanamido)-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.02143
2-(4-aminobenzamido)-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.01778
2-(4-chlorobenzamido)-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.00472
2-(4-fluorobenzamido)-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.02047
2-(4-nitrobenzamido)-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.018
2-(tert-butylamino)-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.00076
2-([1,1'-biphenyl]-4-yl)-2-(3-(ethoxymethyl)-1-hydroxy-2,6-dioxo-1,2,3,6-tetrahydro pyrimidin-4-yl)acetonitrile
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.1
2-acetamido-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
above, pH 7.8, 37°C
0.0071
2-amino-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.002
2-amino-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0201
2-amino-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.0148
2-benzamido-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.0668
2-hydroxy-4-(3-phenyl)propylisoquinoline-1,3(2H,4H)-dione
Human Immunodeficiency Virus
-
pH 8.0, 37°C
0.08
2-hydroxy-4-(4-methylbenzyl)isoquinoline-1,3(2H,4H)-dione
Human Immunodeficiency Virus
-
pH 8.0, 37°C
0.0427
2-hydroxy-4-(4-trifluoromethylbenzyl)isoquinoline-1,3(2H-4H)-dione
Human Immunodeficiency Virus
-
pH 8.0, 37°C
0.0132
2-hydroxy-4-butylisoquinoline-1,3(2H,4H)-dione
Human Immunodeficiency Virus
-
pH 8.0, 37°C
0.0388
2-hydroxy-4-ethylisoquinoline-1,3(2H,4H)-dione
Human Immunodeficiency Virus
-
pH 8.0, 37°C
0.0185
2-hydroxy-4-isopropylisoquinoline-1,3(2H,4H)-dione
Human Immunodeficiency Virus
-
pH 8.0, 37°C
0.000061
2-hydroxy-4-methoxycarbonylisoquinoline-1,3(2H, 4H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000061
2-hydroxy-4-methoxycarbonylisoquinoline-1,3(2H,4H)-dione
Moloney murine leukemia virus
-
pH 8.0, 37°C
0.0388 - 0.07
2-hydroxy-4-methylisoquinoline-1,3(2H,4H)-dione
0.0336
2-hydroxy-4-pentylisoquinoline-1,3(2H,4H)-dione
Human Immunodeficiency Virus
-
pH 8.0, 37°C
0.0468
2-hydroxy-4-propylisoquinoline-1,3(2H,4H)-dione
Human Immunodeficiency Virus
-
pH 8.0, 37°C
0.001507
2-hydroxy-6-methoxy-N-(3-(pyridin-2-ylcarbamoyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)nicotinamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.0013
2-hydroxy-6-phenylisoquinoline-1,3(2H,4H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.00012 - 0.0591
2-hydroxyisoquinoline-1,3(2H,4H)-dione
0.0301
2-hydroxyisoquinoline-1,3(2H,4H)-dione magnesium complex
Moloney murine leukemia virus
-
pH 8.0, 37°C
0.0043
2-oxo-2-(1,2,3,4-tetrahydronaphthalen-1-ylamino)ethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.0019
2-oxo-2-(phenylamino)ethyl dibenzylcarbamodithioate
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0132
2-oxo-2-(propan-2-yloxy)ethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.0042
2-oxo-2-(tetrahydrofuran-2-ylamino)ethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.0266
2-oxo-2-[(2,3,4-trichlorophenyl)amino]ethyl benzyl(phenyl)carbamodithioate
Human immunodeficiency virus 1
-
pH not specified in the publication, temperature not specified in the publication
0.0033
2-oxo-2-[(2,3,4-trichlorophenyl)amino]ethyl dibenzylcarbamodithioate
Human immunodeficiency virus 1
-
pH not specified in the publication, temperature not specified in the publication
0.0082
2-oxo-2-[(2-phenylpropan-2-yl)amino]ethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.0033
2-[(2,3,4-trichlorophenyl)amino]-2-oxoethyl dibenzylcarbamodithioate
Human immunodeficiency virus 1
-
pH 8.0, 25°C
0.0058
2-[(2,4-dichlorophenyl)amino]-2-oxoethyl dibenzylcarbamodithioate
Human immunodeficiency virus 1
-
pH not specified in the publication, temperature not specified in the publication
0.0019
2-[(2,4-dimethylphenyl)amino]-2-oxoethyl dibenzylcarbamodithioate
0.00017
2-[(2-bromo-5-chloro-1-benzothiophen-3-yl)methyl]-5,6-dihydroxypyrimidine-4-carboxylic acid
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0083
2-[(2-methoxy-5-methylphenyl)amino]-2-oxoethyl benzyl(phenyl)carbamodithioate
Human immunodeficiency virus 1
-
pH not specified in the publication, temperature not specified in the publication
0.0043
2-[(2-methyl-1-phenylpropan-2-yl)amino]-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.0058
2-[(2-methylbutan-2-yl)amino]-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.0114
2-[(3-cyanophenyl)amino]-2-oxoethyl benzyl(phenyl)carbamodithioate
Human immunodeficiency virus 1
-
pH not specified in the publication, temperature not specified in the publication
0.0047
2-[(3-cyanophenyl)amino]-2-oxoethyl dibenzylcarbamodithioate
Human immunodeficiency virus 1
-
pH not specified in the publication, temperature not specified in the publication
0.005
2-[(4-hydroxybenzyl)(tetrahydrofuran-2-ylmethyl)amino]-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.0166
2-[(cyclohexanecarbonyl)amino]-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.0012
2-[2-(2-fluoro-benzylamino)-1-hydroxy-1-methyl-ethyl]-5,7-dihydroxy-9-methyl-1,2,3,4-tetrahydrobenzocyclohepten-6-one
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.021
2-[2-(4-bromophenyl)-2-oxoethoxy]-9,10-dioxo-9,10-dihydroanthracen-1-yl acetate
Human immunodeficiency virus 1
-
pH not specified in the publication, temperature not specified in the publication
0.1
2-[2-(biphenyl-4-yl)-2-oxoethoxy]-9,10-dioxo-9,10-dihydroanthracen-1-yl acetate
Human immunodeficiency virus 1
-
pH not specified in the publication, temperature not specified in the publication
0.0099
2-[3-(4-chlorophenyl)propanamido]-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.0145
2-[3-(4-fluorophenyl)propanamido]-N-(pyridin-2-yl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.0017
2-[4-benzyl-5-(benzylsulfanyl)-4H-1,2,4-triazol-3-yl]pyridine
0.0026
2-[4-benzyl-5-[(pyridin-4-ylmethyl)sulfanyl]-4H-1,2,4-triazol-3-yl]pyridine
Human immunodeficiency virus 1
-
pH not specified in the publication, temperature not specified in the publication
0.0077
2-[benzyl(tetrahydrofuran-2-ylmethyl)amino]-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.0142
2-[tert-butyl(2-phenylethyl)amino]-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.0098
2-[tert-butyl(3-nitrobenzyl)amino]-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.05
2-[tert-butyl(3-oxo-3-phenylpropyl)amino]-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.05
2-[tert-butyl(3-phenylpropyl)amino]-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.0085
2-[tert-butyl(4-fluorobenzyl)amino]-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.0075
2-[tert-butyl(4-methoxybenzyl)amino]-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.0069
2-[tert-butyl(4-nitrobenzyl)amino]-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.0068
2-[tert-butyl(pentafluorobenzyl)amino]-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.0009
2-[tert-butyl(phenyl)amino]-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.009
2-[tert-butyl[2-(trifluoromethyl)benzyl]amino]-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.0085
2-[tert-butyl[3-(trifluoromethyl)benzyl]amino]-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.008
2-[tert-butyl[4-(trifluoromethyl)benzyl]amino]-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.0128
2-[[2-(acetyloxy)benzyl](tert-butyl)amino]-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.0087
2-[[4-(acetyloxy)benzyl](tert-butyl)amino]-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.05
2-[[4-(benzyloxy)benzyl](tert-butyl)amino]-2-oxoethyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.0011 - 0.0041
3'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)-[1,1'-biphenyl]-3-carbonitrile
0.0007 - 0.0034
3'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)-[1,1'-biphenyl]-4-carbonitrile
0.0009 - 0.0067
3'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)oxy)-[1,1'-biphenyl]-3-carbonitrile
0.0012 - 0.0069
3'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)oxy)-[1,1'-biphenyl]-4-carbonitrile
0.0001
3'-[(E)-[2-(3,4,5-trihydroxybenzoyl)hydrazinylidene]methyl]biphenyl-4-carboxylic acid
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0219
3,3-dimethyl-2-oxobutyl 5-nitrofuran-2-carboxylate
Human immunodeficiency virus 1
-
pH 7.5, 37°C
0.0081
3-(benzyloxy)-6-((2'-methoxy-[1,1'-biphenyl]-2-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication
0.0065
3-(furan-2-yl)-4-(4-methoxybenzyl)-5-[[4-(trifluoromethyl)benzyl]sulfanyl]-4H-1,2,4-triazole
Human immunodeficiency virus 1
-
pH not specified in the publication, temperature not specified in the publication
0.0047
3-(furan-2-yl)-4-phenyl-5-[[4-(trifluoromethyl)benzyl]sulfanyl]-4H-1,2,4-triazole
Human immunodeficiency virus 1
-
pH not specified in the publication, temperature not specified in the publication
0.0001
3-hydroxy-1,5,6,7-tetrahydro-2H-cyclopenta[4,5]thieno[2,3-d]pyrimidine-2,4(3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0014 - 0.0041
3-hydroxy-1-methyl-6-((3-(pyrimidin-5-yl)phenyl)amino)-pyrimidine-2,4(1H,3H)-dione
0.0095
3-hydroxy-1-methyl-6-((4'-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)-oxy)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication
0.0036 - 0.0089
3-hydroxy-1-methyl-6-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-amino)pyrimidine-2,4(1H,3H)-dione
0.0062
3-hydroxy-1-methyl-6-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)-oxy)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication
0.0017 - 0.0072
3-hydroxy-1-methyl-6-((4'-methyl-[1,1'-biphenyl]-3-yl)amino)-pyrimidine-2,4(1H,3H)-dione
0.0027 - 0.0066
3-hydroxy-1-methyl-6-((4'-methyl-[1,1'-biphenyl]-4-yl)amino)-pyrimidine-2,4(1H,3H)-dione
0.0037 - 0.01
3-hydroxy-1-methyl-6-(4-(pyridin-4-yl)phenoxy)pyrimidine-2,4-(1H,3H)-dione
0.0001
3-hydroxy-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0003
3-hydroxy-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione hydrobromide
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0001
3-hydroxy-5,6-dimethylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0001
3-hydroxy-5-methyl-2,4-dioxo-1,2,3,4-tetrahydrothieno[2,3-d]pyrimidine-6-carboxylic acid
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0001
3-hydroxy-5-methylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0001
3-hydroxy-5-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.011
3-hydroxy-6-((2'-hydroxy-[1,1'-biphenyl]-2-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication
0.00024 - 0.00049
3-hydroxy-6-((2'-hydroxy-[1,1'-biphenyl]-4-yl)amino)pyrimidine-2,4(1H,3H)-dione
0.0012 - 0.0038
3-hydroxy-6-((2'-methoxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione
0.0025 - 0.013
3-hydroxy-6-((2'-methoxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione
0.0028 - 0.0093
3-hydroxy-6-((2'-methoxy-[1,1'-biphenyl]-4-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione
0.0028 - 0.022
3-hydroxy-6-((2'-methoxy-[1,1'-biphenyl]-4-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione
0.000012
3-hydroxy-6-((2-(trifluoromethyl)phenyl)thio)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000017
3-hydroxy-6-((2-methoxyphenyl)thio)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000037
3-hydroxy-6-((3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)methyl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000007
3-hydroxy-6-((3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)thio)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000025
3-hydroxy-6-((3'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000008
3-hydroxy-6-((3'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)thio)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0009 - 0.015
3-hydroxy-6-((3'-hydroxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione
0.00022 - 0.00043
3-hydroxy-6-((3'-hydroxy-[1,1'-biphenyl]-4-yl)amino)pyrimidine-2,4(1H,3H)-dione
0.0057
3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-2-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication
0.0006 - 0.0043
3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione
0.001 - 0.017
3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione
0.0008 - 0.0051
3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-4-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione
0.00015 - 0.00025
3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-4-yl)amino)-pyrimidine-2,4(1H,3H)-dione
0.002 - 0.016
3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-4-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione
0.000005
3-hydroxy-6-((3'-methoxy-[1,1'-biphenyl]-4-yl)thio)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000013
3-hydroxy-6-((3-(trifluoromethyl)phenyl)thio)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000013
3-hydroxy-6-((3-methoxyphenyl)thio)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000013
3-hydroxy-6-((4'-(trifluoromethyl)-[1,1'-biphenyl]-2-yl)thio)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000007
3-hydroxy-6-((4'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)thio)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000047
3-hydroxy-6-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000039
3-hydroxy-6-((4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)thio)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.00038 - 0.0038
3-hydroxy-6-((4'-hydroxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione
0.00018 - 0.00045
3-hydroxy-6-((4'-hydroxy-[1,1'-biphenyl]-4-yl)amino)pyrimidine-2,4(1H,3H)-dione
0.0039 - 0.021
3-hydroxy-6-((4'-hydroxy-[1,1'-biphenyl]-4-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione
0.000004
3-hydroxy-6-((4'-hydroxy-[1,1'-biphenyl]-4-yl)thio)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0023 - 0.022
3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-2-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione
0.0005 - 0.0031
3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-3-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione
0.0002 - 0.0004
3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-3-yl)amino)-pyrimidine-2,4(1H,3H)-dione
0.0004 - 0.0047
3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-3-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione
0.0013 - 0.0066
3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-4-yl)amino)-1-methylpyrimidine-2,4(1H,3H)-dione
0.0016 - 0.012
3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-4-yl)oxy)-1-methylpyrimidine-2,4(1H,3H)-dione
0.000006
3-hydroxy-6-((4'-methoxy-[1,1'-biphenyl]-4-yl)thio)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0004 - 0.0007
3-hydroxy-6-((4'-methyl-[1,1'-biphenyl]-4-yl)amino)pyrimidine-2,4(1H,3H)-dione
0.000031
3-hydroxy-6-((4-(trifluoromethyl)phenyl)thio)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000011
3-hydroxy-6-((4-hydroxyphenyl)thio)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000012
3-hydroxy-6-((4-methoxyphenyl)thio)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000012
3-hydroxy-6-((4-nitrophenyl)thio)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000006
3-hydroxy-6-((40-methyl-[1,1'-biphenyl]-4-yl)thio)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000026
3-hydroxy-6-(4'-(trifluoromethyl)-[1,10-biphenyl]-4-carbonyl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.00053
3-hydroxy-6-(4'-methoxy-[1,10-biphenyl]-4-carbonyl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000081
3-hydroxy-6-(4-(trifluoromethyl)benzoyl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000093
3-hydroxy-6-(4-methylbenzoyl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000021
3-hydroxy-6-(40-methyl-[1,10-biphenyl]-4-carbonyl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000007
3-hydroxy-6-(naphthalen-1-ylthio)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000033
3-hydroxy-6-(p-tolylthio)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000016
3-hydroxy-6-(phenylthio)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0001
3-hydroxy-6-phenylthieno [3,2-d]pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000084
3-hydroxy-6-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0002
3-hydroxy-7-phenylquinazoline-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0002
3-hydroxythieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.029
3-[2-(4-bromophenyl)-2-oxoethoxy]-1,8-dihydroxy-6-methylanthracene-9,10-dione
Human immunodeficiency virus 1
-
-
0.0012 - 0.0037
4'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)-[1,1'-biphenyl]-3-carbonitrile
0.0011 - 0.0037
4'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)amino)-[1,1'-biphenyl]-4-carbonitrile
0.0019 - 0.013
4'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)oxy)-[1,1'-biphenyl]-3-carbonitrile
0.0025 - 0.011
4'-((1-hydroxy-3-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)oxy)-[1,1'-biphenyl]-4-carbonitrile
0.0052
4'-((3-(ethoxymethyl)-1-hydroxy-5-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)methyl)-[1,1'-biphenyl]-4-carbonitrile
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000024
4'-(1-hydroxy-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carbonyl)-[1,1'-biphenyl]-4-carbonitrile
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000398
4-((cyclopropylmethyl)amino)-1-hydroxypyrido[2,3-d]pyrimidin-2(1H)-one
Human immunodeficiency virus 1
-
in 50 mM Tris, pH 8.0, 80 mM KCl, 10 mM MgCl2, at 22°C
0.00001
4-(([1,1'-biphenyl]-4-ylmethyl)amino)-1-hydroxypyrido[2,3-d]pyrimidin-2(1H)-one
Human immunodeficiency virus 1
-
in 50 mM Tris, pH 8.0, 80 mM KCl, 10 mM MgCl2, at 22°C
0.000501
4-(4,4-difluoropiperidin-1-yl)-1-hydroxypyrido[2,3-d]pyrimidin-2(1H)-one
Human immunodeficiency virus 1
-
in 50 mM Tris, pH 8.0, 80 mM KCl, 10 mM MgCl2, at 22°C
0.000032
4-([1,1'-biphenyl]-4-ylamino)-1-hydroxypyrido[2,3-d]pyrimidin-2(1H)-one
Human immunodeficiency virus 1
-
in 50 mM Tris, pH 8.0, 80 mM KCl, 10 mM MgCl2, at 22°C
0.004
4-([[4-benzyl-5-(furan-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl]methyl)pyridine
Human immunodeficiency virus 1
-
pH not specified in the publication, temperature not specified in the publication
0.0002 - 0.2
4-([[4-benzyl-5-(thiophen-2-yl)-4H-1,2,4-triazol-3-yl]sulfanyl]methyl)pyridine
0.0149
4-benzyl-2-hydroxy-isoquinoline-1,3(2H,4H)-dione
Human Immunodeficiency Virus
-
pH 8.0, 37°C
0.0012
4-benzyl-3-(benzylsulfanyl)-5-(furan-2-yl)-4H-1,2,4-triazole
0.00021
4-benzyl-3-(benzylsulfanyl)-5-(thiophen-2-yl)-4H-1,2,4-triazole
0.001
4-benzyl-3-(benzylsulfanyl)-5-phenyl-4H-1,2,4-triazole
0.0038
4-benzyl-3-(furan-2-yl)-5-[(4-methoxybenzyl)sulfanyl]-4H-1,2,4-triazole
Human immunodeficiency virus 1
-
pH not specified in the publication, temperature not specified in the publication
0.0028
4-benzyl-3-[(4-chlorobenzyl)sulfanyl]-5-(furan-2-yl)-4H-1,2,4-triazole
Human immunodeficiency virus 1
-
pH not specified in the publication, temperature not specified in the publication
0.001
4-benzyl-3-[(4-chlorobenzyl)sulfanyl]-5-(thiophen-2-yl)-4H-1,2,4-triazole
0.006
4-benzyl-3-[(4-chlorobenzyl)sulfanyl]-5-phenyl-4H-1,2,4-triazole
Human immunodeficiency virus 1
-
pH not specified in the publication, temperature not specified in the publication
0.001 - 0.0059
4-benzyl-3-[(4-methoxybenzyl)sulfanyl]-5-(thiophen-2-yl)-4H-1,2,4-triazole
0.001
4-benzyl-3-[(4-methoxybenzyl)sulfanyl]-5-phenyl-4H-1,2,4-triazole
Human immunodeficiency virus 1
-
pH 8.0, 25°C
0.045
4-heptyl-2-hydroxy-isoquinoline-1,3(2H,4H)-dione
Human Immunodeficiency Virus
-
pH 8.0, 37°C
0.0078 - 0.038
4-hexyl-2-hydroxy-isoquinoline-1,3(2H,4H)-dione
0.0035
4-tert-butyl-N'-[(E)-(2-hydroxynaphthalen-1-yl)methylidene]benzohydrazide
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0066
4-[1-[(4-fluorophenyl)methyl]-7-(dimethylamino)-4-(1H)-quinolinon-3-yl]-2-hydroxy-4-oxo-2-butenoic acid
Human immunodeficiency virus 1
-
in 50 mM Tris-HCl, pH 8.0, at 37°C
0.0068
4-[1-[(4-fluorophenyl)methyl]-7-(morpholin-4-yl)-4-(1H)-quinolinon-3-yl]-2-hydroxy-4-oxo-2-butenoic acid ethyl ester
Human immunodeficiency virus 1
-
in 50 mM Tris-HCl, pH 8.0, at 37°C
0.0033
4-[1-[(4-fluorophenyl)methyl]-7-(N-acetylpiperazin-1-yl)-4-(1H)-quinolinon-3-yl]-2-hydroxy-4-oxo-2-butenoic acid
Human immunodeficiency virus 1
-
in 50 mM Tris-HCl, pH 8.0, at 37°C
0.0262
4-[1-[(4-fluorophenyl)methyl]-7-(N-ethylpiperazin-1-yl)-4-(1H)-quinolinon-3-yl]-2-hydroxy-4-oxo-2-butenoic acid ethyl ester
Human immunodeficiency virus 1
-
in 50 mM Tris-HCl, pH 8.0, at 37°C
0.0185
4-[1-[(4-fluorophenyl)methyl]-7-(N-methylpiperazin-1-yl)-4-(1H)-quinolinon-3-yl]-2-hydroxy-4-oxo-2-butenoic acid ethyl ester
Human immunodeficiency virus 1
-
in 50 mM Tris-HCl, pH 8.0, at 37°C
0.0287
4-[1-[(4-fluorophenyl)methyl]-7-(piperazin-1-yl)-4-(1H)-quinolinon-3-yl]-2-hydroxy-4-oxo-2-butenoic acid
Human immunodeficiency virus 1
-
in 50 mM Tris-HCl, pH 8.0, at 37°C
0.0057
4-[1-[(4-fluorophenyl)methyl]-7-[N-(3-chloroprop-1-yl)piperazin-1-yl]-4-(1H)-quinolinon-3-yl]-2-hydroxy-4-oxo-2-butenoic acid
Human immunodeficiency virus 1
-
in 50 mM Tris-HCl, pH 8.0, at 37°C
0.0032
4-[5-(benzoylamino)thiophen-2-yl]-2,4-dioxobutanoic acid
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000158
4-[[(4-fluorophenyl)methyl]amino]-1-hydroxypyrido[2,3-d]pyrimidin-2(1H)-one
Human immunodeficiency virus 1
-
in 50 mM Tris, pH 8.0, 80 mM KCl, 10 mM MgCl2, at 22°C
0.000045
4-[[4'-(aminomethyl)biphenyl-4-yl]methyl]-1-hydroxy-1,8-naphthyridin-2(1H)-one
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0012
5,7-dihydroxy-2-(1-hydroxy-1-methyl-2-phenylaminoethyl)-9-methyl-1,2,3,4-tetrahydrobenzocyclohepten-6-one
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.00093
5,7-dihydroxy-2-(1-hydroxy-1-methyl-2-phenylsulfanylethyl)-9-methyl-1,2,3,4-tetrahydrobenzocyclohepten-6-one
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.00082
5,7-dihydroxy-2-(1-hydroxy-1-methyl-2-piperidin-1-ylethyl)-9-methyl-1,2,3,4-tetrahydrobenzocyclohepten-6-one
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.00911
5,7-dihydroxy-2-(1-hydroxy-2-imadazol-1-yl-1-methyl ethyl)-9-methyl-1,2,3,4-tetrahydrobenzocyclohepten-6-one
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.00068
5,7-dihydroxy-2-(1-hydroxy-ethyl)-9-methyl-1,2,3,4-tetrahydrobenzocyclohepten-6-one
Human immunodeficiency virus 1
-
pH 8.0, 37°C
0.00004
5-(4-chlorophenyl)-3-hydroxythieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.015
5-benzyl-6-ethyl-1-(((4-fluorobenzyl)oxy)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.00007
5-bromo-6-((4-bromophenyl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.017
5-ethyl-1-(((4-fluorobenzyl)oxy)methyl)-6-(4-fluorophenyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0038 - 0.0296
5-nitrofuran-2-carboxylic acid adamantan-1-carbamoyl methyl ester
0.0026 - 0.0322
5-nitrofuran-2-carboxylic acid [[4-(4-bromophenyl)-thiazol-2-yl]-(tetrahydrofuran-2-ylmethyl)-carbamoyl]-methyl ester
0.000028
6-( (3'- fluoro-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000085
6-((2',4'-bis(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0000092
6-((2',4'-dichloro-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000015
6-((2',4'-difluoro-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.001 - 0.0042
6-((2',4'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione
0.00031 - 0.0024
6-((2',4'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione
0.0015 - 0.0053
6-((2',4'-dimethoxy-[1,1'-biphenyl]-4-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione
0.0019 - 0.0069
6-((2',6'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione
0.00047 - 0.0007
6-((2',6'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione
0.0066
6-((2-(3,5-dimethylisoxazol-4-yl)phenyl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication
0.000008
6-((2-bromophenyl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.00001
6-((2-ethylphenyl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000015
6-((2-fluorophenyl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0005 - 0.003
6-((3',4'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione
0.000004
6-((3',4'-dimethoxy-[1,10-biphenyl]-4-yl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0006 - 0.004
6-((3',5'-dimethoxy-[1,1'-biphenyl]-3-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione
0.0016 - 0.0092
6-((3',5'-dimethoxy-[1,1'-biphenyl]-4-yl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione
0.00019 - 0.00032
6-((3',5'-dimethoxy-[1,1'-biphenyl]-4-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione
0.0067
6-((3',5'-dimethoxy-[1,1'-biphenyl]-4-yl)methyl)-1-(ethoxymethyl)-3-hydroxy-5-methylpyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000006
6-((3',5'-dimethoxy-[1,1'-biphenyl]-4-yl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000005
6-((3'-chloro-4'-fluoro-[1,1'-biphenyl]-3-yl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000038
6-((3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000015
6-((3'-chloro-5'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000016
6-((3'-chloro-[1,1'-biphenyl ] - 4 -yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.00002
6-((3'-chloro-[1,1'-biphenyl ]-3-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0000077
6-((3'-fluoro-4'-methoxy-[1,1'-biphenyl]-3-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0000076
6-((3'-fluoro-4'-methoxy-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000004
6-((3'-fluoro-4'-methoxy-[1,1'-biphenyl]-4-yl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000018
6-((3'-fluoro-[1,1'-biphenyl]-3-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000006
6-((3'-fluoro-[1,1'-biphenyl]-3-yl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000005
6-((3'-fluoro-[1,1'-biphenyl]-4-yl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000011
6-((3-bromophenyl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000011
6-((3-chlorophenyl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000014
6-((3-fluorophenyl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.00043
6-((4'-chloro-3'-fluoro-[1,1'-biphenyl]-4-yl)methyl)-1-(ethoxymethyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0000094
6-((4'-chloro-3'-fluoro-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000012
6-((4'-chloro-[1,1'-biphenyl ]-3-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0033 - 0.013
6-((4'-chloro-[1,1'-biphenyl]-2-yl)oxy)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione
0.00022 - 0.00045
6-((4'-chloro-[1,1'-biphenyl]-3-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione
0.000005
6-((4'-chloro-[1,1'-biphenyl]-3-yl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.00047 - 0.00066
6-((4'-chloro-[1,1'-biphenyl]-4-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione
0.0024 - 0.011
6-((4'-chloro-[1,1'-biphenyl]-4-yl)oxy)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione
0.000007
6-((4'-chloro-[1,1'-biphenyl]-4-yl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0000088
6-((4'-fluoro-3'-methyl-[1,1'-biphenyl]-3-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000011
6-((4'-fluoro-3'-methyl-[1,1'-biphenyl]-4-yl)methyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000005
6-((4'-fluoro-3'-methyl-[1,1'-biphenyl]-4-yl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000012
6-((4'-fluoro-[1,1'-biphenyl]-2-yl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0002 - 0.0003
6-((4'-fluoro-[1,1'-biphenyl]-3-yl)amino)-3-hydroxypyrimidine-2,4(1H,3H)-dione
0.000005
6-((4'-fluoro-[1,1'-biphenyl]-3-yl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000006
6-((4'-fluoro-[1,1'-biphenyl]-4-yl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0016 - 0.0044
6-((4-(3,5-dimethylisoxazol-4-yl)phenyl)amino)-3-hydroxy-1-methylpyrimidine-2,4(1H,3H)-dione
0.00012
6-((4-bromophenyl)thio)-3-hydroxy-5-iodopyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.00001
6-((4-bromophenyl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000012
6-((4-chlorophenyl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.00001
6-((4-ethylphenyl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000037
6-((4-fluorophenyl)thio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000074
6-(3',4'-dimethoxy-[1,10-biphenyl]-4-carbonyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000063
6-(3',5'-dimethyl-[1,10-biphenyl]-4-carbonyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.00009
6-(3,5-dimethylbenzoyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000013
6-(3-bromobenzyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000023
6-(4'-chloro-3'-fluoro-[1,10-biphenyl]-4-carbonyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000019
6-(4'-fluoro-3'-methyl-[1,10-biphenyl]-4-carbonyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000027
6-(4'-fluoro-[1,1'-biphenyl]-4-carbonyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000011
6-(4-bromobenzyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.00007
6-(4-chlorophenyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000085
6-(4-fluorobenzoyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0002
6-(4-fluorophenyl)-3-hydroxythieno[3,2-d]pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0047
6-([1,1'-biphenyl]-2-yloxy)-3-hydroxy-1-methylpyrimidine-2,4-(1H,3H)-dione
Human immunodeficiency virus 1
-
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication
0.0011
6-([1,1'-biphenyl]-3-carbonyl)-1-(ethoxymethyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000017
6-([1,1'-biphenyl]-3-carbonyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.00085 - 0.0035
6-([1,1'-biphenyl]-3-ylamino)-3-hydroxy-1-methylpyrimidine-2,4-(1H,3H)-dione
0.000016
6-([1,1'-biphenyl]-3-ylmethyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.001
6-([1,1'-biphenyl]-3-yloxy)-3-hydroxy-1-methylpyrimidine-2,4-(1H,3H)-dione
Human immunodeficiency virus 1
-
enzyme activity reaction with substrate HTS-1, pH and temperature not specified in the publication
0.00042
6-([1,1'-biphenyl]-4-carbonyl)-1-(ethoxymethyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000022
6-([1,1'-biphenyl]-4-carbonyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0062
6-([1,1'-biphenyl]-4-yl)-1-(ethoxymethyl)-3-hydroxy-5-methylpyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0008 - 0.0051
6-([1,1'-biphenyl]-4-ylamino)-3-hydroxy-1-methylpyrimidine-2,4-(1H,3H)-dione
0.005
6-([1,1'-biphenyl]-4-ylmethyl)-1-(ethoxymethyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000016
6-([1,1'-biphenyl]-4-ylmethyl)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0019 - 0.006
6-([1,1'-biphenyl]-4-yloxy)-3-hydroxy-1-methylpyrimidine-2,4-(1H,3H)-dione
0.00009
6-([1,1'-biphenyl]-4-ylthio)-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.011
6-benzyl-1-(((4-fluorobenzyl)oxy)methyl)-5-isopropyl-3-methoxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.007
6-benzyl-1-(((4-fluorobenzyl)oxy)methyl)-5-isopropyl-3-methylpyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0068
6-benzyl-1-(ethoxymethyl)-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0025
6-benzyl-1-[(benzyloxy)methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0066
6-benzyl-1-[2-(4-fluorophenyl)ethyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0038
6-benzyl-1-[3-(4-fluorophenyl)propyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0009
6-benzyl-1-[4-(4-fluorophenyl)butyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0018
6-benzyl-1-[[(2,4-difluorophenyl)methoxy]methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0009
6-benzyl-1-[[(3-chloro-2-fluorophenyl)methoxy]methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0021
6-benzyl-1-[[(4-fluorophenyl)methoxy]methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0028
6-benzyl-1-[[3-(4-fluorophenyl)propoxy]methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0018
6-benzyl-1-[[4-(4-fluorophenyl)butoxy]methyl]-3-hydroxy-5-(propan-2-yl)pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000043
6-benzyl-3-hydroxythieno[2,3-d]pyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.00022
6-[(4'-chloro[1,1'-biphenyl]-3-yl)amino]-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.00025
6-[([1,1'-biphenyl]-4-yl)amino]-3-hydroxypyrimidine-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.00013
6-[1-(4-fluorophenyl)methyl-1H-pyrrol-2-yl]-2,4-dioxo-5-hexenoic acid ethyl ester
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0002
7-(4-chlorophenyl)-3-hydroxyquinazoline-2,4(1H,3H)-dione
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0001
7-benzyl-3-hydroxy-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione hydrochloride
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.00033
7-benzyl-3-hydroxyhexahydropyrido[3,4-d]pyrimidine-2,4(1H,3H)-dione hydrochloride
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0002
7-ethyl-3-hydroxy-5,6,7,8-tetrahydropyrido[4',3':4,5]thieno[2,3-d]pyrimidine-2,4(1H,3H)-dione hydrochloride
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.039
9,10-dioxo-2-(2-oxo-2-phenylethoxy)-9,10-dihydroanthracen-1-yl acetate
Human immunodeficiency virus 1
-
pH not specified in the publication, temperature not specified in the publication
0.013
9,10-dioxo-9,10-dihydroanthracene-1,2-diyl dibenzoate
Human immunodeficiency virus 1
-
pH not specified in the publication, temperature not specified in the publication
0.000186 - 0.00047
ARK-2452
-
0.00007 - 0.0038
beta-thujaplicinol
0.01
dolutegravir
Human immunodeficiency virus 1
-
above, pH and temperature not specified in the publication
0.0082
ethyl (5E)-6-[1-(2,4-dimethylbenzyl)-1H-pyrrol-2-yl]-2,4-dioxohex-5-enoate
Human immunodeficiency virus 1
-
at pH 7.8 and 37°C
0.0073
ethyl (5E)-6-[1-(2-chlorobenzyl)-1H-pyrrol-2-yl]-2,4-dioxohex-5-enoate
Human immunodeficiency virus 1
-
at pH 7.8 and 37°C
0.0063
ethyl (5E)-6-[1-(3-methoxybenzyl)-1H-pyrrol-2-yl]-2,4-dioxohex-5-enoate
Human immunodeficiency virus 1
-
at pH 7.8 and 37°C
0.0086
ethyl (5E)-6-[1-(4-fluorobenzyl)-1H-pyrrol-2-yl]-2,4-dioxohex-5-enoate
Human immunodeficiency virus 1
-
at pH 7.8 and 37°C
0.0112
ethyl (5E)-6-[1-(4-fluorobenzyl)-1H-pyrrol-3-yl]-2,4-dioxohex-5-enoate
Human immunodeficiency virus 1
-
at pH 7.8 and 37°C
0.008
ethyl (5E)-6-[1-(4-fluorobenzyl)-4-phenyl-1H-pyrrol-3-yl]-2,4-dioxohex-5-enoate
Human immunodeficiency virus 1
-
at pH 7.8 and 37°C
0.00011
ethyl 1,4-dihydroxy-2-oxo-1,2-dihydro-1,8-naphthyridine-3-carboxylate
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0252
ethyl 2-(2-fluorobenzamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.07258
ethyl 2-(4-chlorobenzamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxylate
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.0011 - 0.0048
F3284-8495
0.0019 - 0.0022
F3385-2581
0.0007 - 0.0021
F3385-2588
0.0004 - 0.0008
F3385-2590
0.00033
GSK5750
Human immunodeficiency virus 1
-
at pH 7.8 and 37°C
0.000015
methyl 4'-(1-hydroxy-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carbonyl)-[1,10-biphenyl]-4-carboxylate
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.000031
methyl 4-(1-hydroxy-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carbonyl)benzoate
Human immunodeficiency virus 1
-
pH and temperature not specified in the publication
0.0137
N-(3-((2-fluorophenyl)carbamoyl)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophen-2-yl)picolinamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.01036
N-(pyridin-2-yl)-2-(thiophene-2-carboxamido)-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.01644
N-(pyridin-2-yl)-2-[2-(quinolin-6-yl)acetamido]-5,6,7,8-tetrahydro-4H-cyclohepta[b]thiophene-3-carboxamide
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.004
NSC727447
Human immunodeficiency virus type 1 group M subtype B
pH 7.8, 37°C
0.01
raltegravir
Human immunodeficiency virus 1
-
above, pH and temperature not specified in the publication
0.0022 - 0.003
[2-(4-chlorophenyl)hydrazinylidene]propanedioic acid