3.1.26.13: retroviral ribonuclease H

This is an abbreviated version, for detailed information about retroviral ribonuclease H, go to the full flat file.

Reaction

Endohydrolysis of RNA in RNA/DNA hybrids. Three different cleavage modes: 1. sequence-specific internal cleavage of RNA. Human immunodeficiency virus type 1 and Moloney murine leukemia virus enzymes prefer to cleave the RNA strand one nucleotide away from the RNA-DNA junction. 2. RNA 5'-end directed cleavage 13-19 nucleotides from the RNA end. 3. DNA 3'-end directed cleavage 15-20 nucleotides away from the primer terminus. =

Synonyms

HIV-1 reverse transcriptase, HIV-1 RT-associated RNase H, human immunodeficiency virus reverse transcriptase, human immunodeficiency virus reverse transcriptase-associated ribonuclease H, M-MuLV RT RNase H, reverse transcriptase, reverse transcriptase-associated ribonuclease H, ribonuclease H, RNase H, RT RNase H, RT-RNase H

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.26 Endoribonucleases producing 5'-phosphomonoesters
                3.1.26.13 retroviral ribonuclease H