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3.1.22.1: deoxyribonuclease II

This is an abbreviated version!
For detailed information about deoxyribonuclease II, go to the full flat file.

Word Map on EC 3.1.22.1

Reaction

endonucleolytic cleavage to nucleoside 3'-phosphates and 3'-phosphooligonucleotide end-products =

Synonyms

acid deoxyribonuclease, acid DNase, crn-7, deoxyribonuclease II, deoxyribonuclease IIalpha, deoxyribonuclease IIbeta, deoxyribonucleate 3'-nucleotidohydrolase, DNase 2, DNase 2a, DNase II, DNase II homolog, DNase II-1, DNase II-7, DNase IIalpha, DNase IIb, DNase IIbeta, EC 3.1.4.6, L-DNase II, LEI, LEI-derived DNase II, LEI/L-DNase II, leukocyte elastase inhibitor-derived DNase II, leukocyte elastase inhibitor/LEI-derived DNase II, lysosomal DNase II, Nuc-1, NUC-1 apoptotic nuclease, pancreatic DNase II, plancitoxin 1, R31240_2, Sjda, TsDNase II-1, TsDNase II-7

ECTree

     3 Hydrolases
         3.1 Acting on ester bonds
             3.1.22 Endodeoxyribonucleases producing 3'-phosphomonoesters
                3.1.22.1 deoxyribonuclease II

Localization

Localization on EC 3.1.22.1 - deoxyribonuclease II

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LOCALIZATION
ORGANISM
UNIPROT
COMMENTARY hide
GeneOntology No.
LITERATURE
SOURCE
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during early differentiation, localization to lysosome. Later, an increasing portion of enzyme is found in cytosol
Manually annotated by BRENDA team
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45-kDa form of recombinant DNase II
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Manually annotated by BRENDA team
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fraction of procaspase-8 and LEI colocalise in the mitochondria. After etoposide treatment, cathepsin D is released from lysosomes and part of it colocalises with caspase-8 and LEI
Manually annotated by BRENDA team
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mitochondrial-lysosomal fraction
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Manually annotated by BRENDA team
additional information
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putative leucine-rich nuclear export signal on LEI/L-DNase II sequence, a mandatory condition for binding exportin molecules. The exportin Crm1 interacts with LEI/L-DNase II
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Manually annotated by BRENDA team