3.1.21.7: deoxyribonuclease V

This is an abbreviated version!
For detailed information about deoxyribonuclease V, go to the full flat file.

Word Map on EC 3.1.21.7

3.1.21.7

nick

deaminate

phosphodiester

beta-polymerase

deoxyinosine-containing

3\'-hydroxyl

proofreading

biotechnology

analysis

molecular biology

drug development

medicine

Reaction

endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate =

Synonyms

AGTendoV, deoxyinosine 3' endonuclease, Deoxyinosine 3'endonuclease, DNase V, EC 3.1.22.3, endo V, endodeoxyribonuclease V, endonuclease V, EndoV, Escherichia coli endodeoxyribonuclease V, nfi, PF0987, PfuEndoV, T4 endonuclease V, T4 UV endonuclease, Tb10.6k15.3890

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.21 Endodeoxyribonucleases producing 5'-phosphomonoesters

3.1.21.7 deoxyribonuclease V

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4	Activating Compound
8025	AA Sequence
5	Application
1	CAS Registry Number
19	Cloned(Commentary)
8	Crystallization (Commentary)
4	Disease/ Diagnostics
20	General Information
1	General Stability
18	Inhibitors
4	KM Value [mM]
13	Localization
27	Metals/Ions
13	Molecular Weight [Da]
38	Natural Substrates/ Products (Substrates)
63	Organism
18	PDB ID
13	pH Optimum
3	pH Range
2	pH Stability
1	pI Value
99	Protein Variants
29	Purification (Commentary)
1	Reaction
2	Reaction Type
63	Reference
19	Source Tissue
3	Specific Activity [micromol/min/mg]
1	Storage Stability
100	Substrates and Products (Substrate)
9	Subunits
70	Synonyms
7	Temperature Optimum [°C]
2	Temperature Range [°C]
1	Temperature Stability [°C]
6	Turnover Number [1/s]

Activating Compound

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Activating Compound on EC 3.1.21.7 - deoxyribonuclease V

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ATP

Escherichia coli

required

714813

polyadenylate-binding protein C1

Homo sapiens

Q8N8Q3

the association between polyadenylate-binding protein C1 and hEndoV is RNA dependent. Polyadenylate-binding protein stimulates hEndoV activity and affinity for inosine-containing RNA. Upon cellular stress, polyadenylate-binding protein C1 relocates to cytoplasmic stress granules

751068

additional information

2 entries