3.1.21.5: type III site-specific deoxyribonuclease
This is an abbreviated version!
For detailed information about type III site-specific deoxyribonuclease, go to the full flat file.
Word Map on EC 3.1.21.5
Reaction
endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates =
Synonyms
ATP-dependent type III restriction endonuclease, BceSI, BsaHI, cj0031, EC 3.1.23, EC 3.1.24, EcoP1, EcoP15, EcoP15I, EcoPI, HinFIII, LlaFI, MmyCI, More, NgoAXP, PhaBI, PspGI, PstII, R.EcoP15I, R.MmyCI, REase, restriction endonuclease PstII, restriction-modification system, StyLTI, type III DNA restriction/modification enzyme, type III R-M enzyme, type III R/M enzyme, type III RE, type III restriction endonuclease, type III restriction enzyme, type III restriction-modification enzyme, type III restriction-modification system, type III RM system, type III testriction-modification enzyme, type III-like restriction endonuclease
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Reference on EC 3.1.21.5 - type III site-specific deoxyribonuclease
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Roberts, R.J.
Restriction enzymes and their isoschizomers
Nucleic Acids Res.
18
2331-2365
1990
Escherichia coli, Haemophilus influenzae, Salmonella enterica subsp. enterica serovar Typhi
Roberts, R.J.
Restriction and modification enzymes and their recognition sequences
Nucleic Acids Res.
11
r135-r167
1983
Escherichia coli
Roberts, R.J.; Macelis, D.
REBASE - restriction enzymes and methylases
Nucleic Acids Res.
29
268-269
2001
Escherichia coli
Kruger, D.H.; Kupper, D.; Meisel, A.; Tierlich, M.; Reuter, M.; Schroeder, C.
Restriction endonucleases functionally interacting with two DNA sites
Gene
157
165
1995
Escherichia coli
Gorbalenya, A.E.; Koonin, E.V.
Endonuclease (R) subunit of type-I and type-III restriction-modification enzymes contain a helicase-like domain
FEBS Lett.
291
277-281
1991
Escherichia coli
Kunz, A.; Mackeldanz, P.; Mucke, M.; Meisel, A.; Reuter, M.; Schroeder, C.; Kruger, D.H.
Mutual activation of two restriction endonucleases: interaction of EcoP1 and EcoP15
Biol. Chem.
379
617-620
1998
Escherichia coli
Su, P.; Im, H.; Hsieh, H.; Kang'a, S.; Dunn, N.W.
LlaFI, a type III restriction and modification system in Lactococcus lactis
Appl. Environ. Microbiol.
65
686-693
1999
Lactococcus lactis
Meisel, A.; Bickle, T.A.; Kruger, T.A.; Kruger, D.H.; Schroeder, C.
Type III restriction enzymes need two inversely oriented recognition sites for DNA cleavage
Nature
355
467-469
1992
Escherichia coli
Meisel, A.; Mackeldanz, P.; Bickle, T.A.; Kruger, D.H.; Schroeder, C.
Type III restriction endonucleases translocate DNA in a reaction driven by recognition site-specific ATP hydrolysis
EMBO J.
14
2958-2966
1995
Escherichia coli
Saha, S.; Rao, D.N.
Mutations in the Res subunit of the EcoPI restriction enzyme that affect ATP-dependent reactions
J. Mol. Biol.
269
342-354
1997
Escherichia coli
Hegna, I.K.; Bratland, H.; Kolsto, A.B.
BceS1, a new addition to the type III restriction and modification family
FEMS Microbiol. Lett.
202
189-193
2001
Bacillus cereus (P25241)
Janscak, P.; Sandmeier, U.; Szczelkun, M.D.; Bickle, T.A.
Subunit assembly and mode of DNA cleavage of the type III restriction endonucleases EcoP1I and EcoP15I
J. Mol. Biol.
306
417-431
2001
Escherichia coli, prophage P1
Bist, P.; Sistla, S.; Krishnamurthy, V.; Acharya, A.; Chandrakala, B.; Rao, D.N.
S-adenosyl-L-methionine is required for DNA cleavage by type III restriction enzymes
J. Mol. Biol.
310
93-109
2001
Escherichia coli
Mucke, M.; Reich, S.; Moncke-Buchner, E.; Reuter, M.; Kruger, D.H.
DNA cleavage by type III restriction-modification enzyme EcoP15I is independent of spacer distance between two head to head oriented recognition sites
J. Mol. Biol.
312
687-698
2001
Escherichia coli
Peakman, L.J.; Antognozzi, M.; Bickle, T.A.; Janscak, P.; Szczelkun, M.D.
S-adenosyl methionine prevents promiscuous DNA cleavage by the EcoP1I type III restriction enzyme
J. Mol. Biol.
333
321-335
2003
prophage P1
Reich, S.; Gossl, I.; Reuter, M.; Rabe, J.P.; Kruger, D.H.
Scanning force microscopy of DNA translocation by the type III restriction enzyme EcoP15I
J. Mol. Biol.
341
337-343
2004
Escherichia coli
Dryden, D.T.; Murray, N.E.; Rao, D.N.
Nucleoside triphosphate-dependent restriction enzymes
Nucleic Acids Res.
29
3728-3741
2001
Escherichia coli
Handa, N.; Kobayashi, I.
Type III restriction is alleviated by bacteriophage (RecE) homologous recombination function but enhanced by bacterial (RecBCD) function
J. Bacteriol.
187
7362-7373
2005
Escherichia coli
Möncke-Buchner, E.; Mackeldanz, P.; Kruger, D.H.; Reuter, M.
Overexpression and affinity chromatography purification of the Type III restriction endonuclease EcoP15I for use in transcriptome analysis
J. Biotechnol.
114
99-106
2004
Escherichia coli
Peakman, L.J.; Szczelkun, M.D.
DNA communications by Type III restriction endonucleases--confirmation of 1D translocation over 3D looping
Nucleic Acids Res.
32
4166-4174
2004
Escherichia coli
Raghavendra, N.K.; Rao, D.N.
Unidirectional translocation from recognition site and a necessary interaction with DNA end for cleavage by Type III restriction enzyme
Nucleic Acids Res.
32
5703-5711
2004
Escherichia coli
Sears, A.; Szczelkun, M.D.
Subunit assembly modulates the activities of the Type III restriction-modification enzyme PstII in vitro
Nucleic Acids Res.
33
4788-4796
2005
Providencia stuartii, Providencia stuartii 164
Crampton, N.; Roes, S.; Dryden, D.T.; Rao, D.N.; Edwardson, J.M.; Henderson, R.M.
DNA looping and translocation provide an optimal cleavage mechanism for the type III restriction enzymes
EMBO J.
26
3815-3825
2007
Escherichia coli, Escherichia coli P15I
Wagenfuehr, K.; Pieper, S.; Mackeldanz, P.; Linscheid, M.; Krueger, D.H.; Reuter, M.
Structural domains in the type III restriction endonuclease EcoP15I: characterization by limited proteolysis, mass spectrometry and insertional mutagenesis
J. Mol. Biol.
366
93-102
2007
Escherichia coli
Fox, K.L.; Dowideit, S.J.; Erwin, A.L.; Srikhanta, Y.N.; Smith, A.L.; Jennings, M.P.
Haemophilus influenzae phasevarions have evolved from type III DNA restriction systems into epigenetic regulators of gene expression
Nucleic Acids Res.
35
5242-5252
2007
Haemophilus influenzae
Crampton, N.; Yokokawa, M.; Dryden, D.T.; Edwardson, J.M.; Rao, D.N.; Takeyasu, K.; Yoshimura, S.H.; Henderson, R.M.
Fast-scan atomic force microscopy reveals that the type III restriction enzyme EcoP15I is capable of DNA translocation and looping
Proc. Natl. Acad. Sci. USA
104
12755-12760
2007
Escherichia coli
Neely, R.K.; Roberts, R.J.
The BsaHI restriction-modification system: cloning, sequencing and analysis of conserved motifs
BMC Mol. Biol.
9
48
2008
Geobacillus stearothermophilus (B0LX59)
Moencke-Buchner, E.; Rothenberg, M.; Reich, S.; Wagenfuehr, K.; Matsumura, H.; Terauchi, R.; Krueger, D.H.; Reuter, M.
Functional characterization and modulation of the DNA cleavage efficiency of type III restriction endonuclease EcoP15I in its interaction with two sites in the DNA target
J. Mol. Biol.
387
1309-1319
2009
Escherichia coli
Carpenter, M.A.; Bhagwat, A.S.
DNA base flipping by both members of the PspGI restriction-modification system
Nucleic Acids Res.
36
5417-5425
2008
Pyrococcus sp. GI-H
Ramanathan, S.P.; van Aelst, K.; Sears, A.; Peakman, L.J.; Diffin, F.M.; Szczelkun, M.D.; Seidel, R.
Type III restriction enzymes communicate in 1D without looping between their target sites
Proc. Natl. Acad. Sci. USA
106
1748-1753
2009
Escherichia coli
Adamczyk-Poplawska, M.; Lower, M.; Piekarowicz, A.
Characterization of the NgoAXP: phase-variable type III restriction-modification system in Neisseria gonorrhoeae
FEMS Microbiol. Lett.
300
25-35
2009
Neisseria gonorrhoeae (Q5F957), Neisseria gonorrhoeae
Schwarz, F.W.; van Aelst, K.; Toth, J.; Seidel, R.; Szczelkun, M.D.
DNA cleavage site selection by Type III restriction enzymes provides evidence for head-on protein collisions following 1D bidirectional motion
Nucleic Acids Res.
39
8042-8051
2011
Escherichia coli
Corvaglia, A.R.; Francois, P.; Hernandez, D.; Perron, K.; Linder, P.; Schrenzel, J.
A type III-like restriction endonuclease functions as a major barrier to horizontal gene transfer in clinical Staphylococcus aureus strains
Proc. Natl. Acad. Sci. USA
107
11954-11958
2010
Escherichia coli, Staphylococcus aureus
Van Aelst, K.; Toth, J.; Ramanathan, S.; Schwarz, F.; Seidel, R.; Szczelkun, M.
Type III restriction enzymes cleave DNA by long-range interaction between sites in both head-to-head and tail-to-tail inverted repeat
Proc. Natl. Acad. Sci. USA
107
9123-9128
2010
Escherichia coli
Gupta, Y.K.; Yang, L.; Chan, S.H.; Samuelson, J.C.; Xu, S.Y.; Aggarwal, A.K.
Structural insights into the assembly and shape of Type III restriction-modification (R-M) EcoP15I complex by small-angle X-ray scattering
J. Mol. Biol.
420
261-268
2012
Escherichia coli
Toth, J.; van Aelst, K.; Salmons, H.; Szczelkun, M.D.
Dissociation from DNA of Type III Restriction-Modification enzymes during helicase-dependent motion and following endonuclease activity
Nucleic Acids Res.
40
6752-6764
2012
Escherichia coli
Rao, D.N.; Dryden, D.T.; Bheemanaik, S.
Type III restriction-modification enzymes: a historical perspective
Nucleic Acids Res.
42
45-55
2014
Bacillus cereus, Escherichia coli, Haemophilus influenzae, Helicobacter pylori, Lactococcus lactis, Mannheimia haemolytica, Neisseria gonorrhoeae, Providencia stuartii, Salmonella enterica subsp. enterica serovar Typhimurium, Escherichia coli 15T-
Butterer, A.; Pernstich, C.; Smith, R.M.; Sobott, F.; Szczelkun, M.D.; Toth, J.
Type III restriction endonucleases are heterotrimeric: comprising one helicase-nuclease subunit and a dimeric methyltransferase that binds only one specific DNA
Nucleic Acids Res.
42
5139-5150
2014
Escherichia coli, Providencia stuartii
Algire, M.A.; Montague, M.G.; Vashee, S.; Lartigue, C.; Merryman, C.
A type III restriction-modification system in Mycoplasma mycoides subsp. capri
Open Biology
2
120115
2012
Mycoplasma mycoides subsp. capri, Mycoplasma mycoides subsp. capri GM12
Schwarz, F.W.; Toth, J.; van Aelst, K.; Cui, G.; Clausing, S.; Szczelkun, M.D.; Seidel, R.
The helicase-like domains of type III restriction enzymes trigger long-range diffusion along DNA
Science
340
353-356
2013
Escherichia coli
Toth, J.; Bollins, J.; Szczelkun, M.D.
Re-evaluating the kinetics of ATP hydrolysis during initiation of DNA sliding by Type III restriction enzymes
Nucleic Acids Res.
43
10870-10881
2015
Punavirus P1 (P08764), Escherichia coli (P12364)
Anjum, A.; Brathwaite, K.J.; Aidley, J.; Connerton, P.L.; Cummings, N.J.; Parkhill, J.; Connerton, I.; Bayliss, C.D.
Phase variation of a Type IIG restriction-modification enzyme alters site-specific methylation patterns and gene expression in Campylobacter jejuni strain NCTC11168
Nucleic Acids Res.
44
4581-4594
2016
Campylobacter jejuni (Q0PC94), Campylobacter jejuni NCTC 11168 (Q0PC94)
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