3.1.21.2: deoxyribonuclease IV

This is an abbreviated version!
For detailed information about deoxyribonuclease IV, go to the full flat file.

Word Map on EC 3.1.21.2

3.1.21.2

exonuclease

ape1

glycosylase

abasic

strand

endonucleases

single-stranded

nick

uracil

duplex

phosphodiester

uracil-dna

methanesulfonate

3'-blocking

8-oxoguanine

3'-phosphatase

depurinated

deoxyribose

3\'-hydroxyl

xrcc1

diesterase

incise

site-containing

base-excision

endonucleolytic

8-oxog

soxrs

ap-site

5'-deoxyribose

cross-complementing

non-ltr

repair-deficient

exoiiis

5'-phosphorylated

uracil-containing

non-long

3'-phosphoglycolate

asp148glu

analysis

pharmacology

Reaction

Endonucleolytic cleavage of ssDNA at apurinic/apyrimidinic sites to 5'-phosphooligonucleotide end-products =

Synonyms

apurinic/apyrimidinic endonuclease, coliphage T4 endonuclease II, deoxriboendonuclease, DNA-adenine-transferase, E. coli endonuclease IV, EC 3.1.4.30, End, Endo IV, endodeoxyribonuclease IV, EndoII, EndoIV, endonuclease II, endonuclease IV, exonuclease III, More, MtbEndo IV, MtbNfo, MtbXthA, Nfo, nuclease, endodeoxyribo-oder redoxyendonuclease, Rv0670, Sco4631, ScoA3McrA, T4 endonuclease IV, TthNfo, type IV methyl-dependent restriction endonuclease

ECTree

3 Hydrolases

3.1 Acting on ester bonds

3.1.21 Endodeoxyribonucleases producing 5'-phosphomonoesters

3.1.21.2 deoxyribonuclease IV

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Results	in table
3	Activating Compound
17104	AA Sequence
3	Application
2	CAS Registry Number
8	Cloned(Commentary)
5	Crystallization (Commentary)
287	Disease/ Diagnostics
19	General Information
1	General Stability
18	Inhibitors
5	kcat/KM [mM/s]
10	KM Value [mM]
31	Metals/Ions
8	Molecular Weight [Da]
13	Natural Substrates/ Products (Substrates)
234	Organism
39	PDB ID
8	pH Optimum
2	pH Range
10	Protein Variants
10	Purification (Commentary)
3	Reaction
2	Reaction Type
32	Reference
1	Source Tissue
1	Specific Activity [micromol/min/mg]
2	Storage Stability
46	Substrates and Products (Substrate)
6	Subunits
63	Synonyms
7	Temperature Optimum [°C]
1	Temperature Range [°C]
4	Temperature Stability [°C]
6	Turnover Number [1/s]

Subunits

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Subunits on EC 3.1.21.2 - deoxyribonuclease IV

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4 entries

tetramer

Tequatrovirus T4

4 * 16000

715906

additional information

Tequatrovirus T4

EndoII forms a striking X-shaped tetrameric structure composed as a dimer of dimers, with a protruding hairpin domain not present in UvrC or I-TevI providing most of the dimerization and tetramerization interfaces. Monomer structure and topology, quarternary structure, overview

715906