3.1.21.2: deoxyribonuclease IV
This is an abbreviated version!
For detailed information about deoxyribonuclease IV, go to the full flat file.
Word Map on EC 3.1.21.2
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3.1.21.2
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exonuclease
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ape1
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glycosylase
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abasic
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strand
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endonucleases
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single-stranded
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nick
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uracil
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duplex
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phosphodiester
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uracil-dna
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methanesulfonate
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3'-blocking
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8-oxoguanine
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3'-phosphatase
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depurinated
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deoxyribose
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3\'-hydroxyl
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xrcc1
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diesterase
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incise
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site-containing
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base-excision
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endonucleolytic
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8-oxog
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soxrs
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ap-site
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5'-deoxyribose
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cross-complementing
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non-ltr
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repair-deficient
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exoiiis
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5'-phosphorylated
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uracil-containing
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non-long
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3'-phosphoglycolate
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asp148glu
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analysis
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pharmacology
- 3.1.21.2
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exonuclease
- ape1
- glycosylase
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abasic
- strand
- endonucleases
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single-stranded
- nick
- uracil
- duplex
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phosphodiester
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uracil-dna
- methanesulfonate
-
3'-blocking
- 8-oxoguanine
-
3'-phosphatase
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depurinated
- deoxyribose
-
3\'-hydroxyl
- xrcc1
- diesterase
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incise
-
site-containing
-
base-excision
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endonucleolytic
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8-oxog
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soxrs
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ap-site
-
5'-deoxyribose
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cross-complementing
-
non-ltr
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repair-deficient
- exoiiis
-
5'-phosphorylated
-
uracil-containing
-
non-long
-
3'-phosphoglycolate
-
asp148glu
- analysis
- pharmacology
Reaction
Endonucleolytic cleavage of ssDNA at apurinic/apyrimidinic sites to 5'-phosphooligonucleotide end-products =
Synonyms
apurinic/apyrimidinic endonuclease, coliphage T4 endonuclease II, deoxriboendonuclease, DNA-adenine-transferase, E. coli endonuclease IV, EC 3.1.4.30, End, Endo IV, endodeoxyribonuclease IV, EndoII, EndoIV, endonuclease II, endonuclease IV, exonuclease III, More, MtbEndo IV, MtbNfo, MtbXthA, Nfo, nuclease, endodeoxyribo-oder redoxyendonuclease, Rv0670, Sco4631, ScoA3McrA, T4 endonuclease IV, TthNfo, type IV methyl-dependent restriction endonuclease
ECTree
3.1.21.2 deoxyribonuclease IVAdvanced search results
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results (Natural Substrates Products
Natural Substrates Products on EC 3.1.21.2 - deoxyribonuclease IV
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NATURAL SUBSTRATE 
NATURAL PRODUCT
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
(Substrate)
LITERATURE
(Substrate)
(Substrate)
COMMENTARY
(Product)
(Product)
LITERATURE
(Product)
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
r=reversible
ir=irreversible
?=not specified
double-stranded nativeDNA + H2O
5'-phosphooligonucleotides
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endonucleolytic cleavage of DNA into 5'-phosphooligonucleotides
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-
ir
double-stranded alkylated DNA + H2O
5'-phosphooligonucleotides
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endonucleolytic cleavage of DNA into 5'-phosphooligonucleotides
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-
ir
double-stranded alkylated DNA + H2O
5'-phosphooligonucleotides
Tequatrovirus T4
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in vivo the enzyme produces mostly double-stranded fragments with a few internal nicks
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-
ir
single-stranded DNA + H2O
5'-phosphooligonucleotides
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breakdown of host cell DNA occuring after T4 phage infection
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ir
single-stranded DNA + H2O
5'-phosphooligonucleotides
Escherichia coli B / ATCC 11303
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breakdown of host cell DNA occuring after T4 phage infection
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ir
single-stranded DNA + H2O
5'-phosphooligonucleotides
Tequatrovirus T4
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the Ser176 of T4 endonuclease IV is crucial for the restricted and polarized dC-specific cleavage of single-stranded DNA implicated in restriction of dC-containing DNA in host Escherichia coli
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-
?
additional information
?
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role for Endo IV to counteract DNA damage induced by the oxidative counterpart of UVB in Escherichia coli
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-
?
additional information
?
-
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role for Endo IV to counteract DNA damage induced by the oxidative counterpart of UVB in Escherichia coli
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-
?
additional information
?
-
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Nfo-catalyzed nucleotide incision repair and exonuclease activities can generate a single-strand gap at the 5' side of 5,6-dihydrouracil residue
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-
?
additional information
?
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Nfo-catalyzed nucleotide incision repair and exonuclease activities can generate a single-strand gap at the 5' side of 5,6-dihydrouracil residue
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-
?
additional information
?
-
-
a His-tagged derivative of ScoA3McrA cleaves S-modified DNA and also Dcm-methylated DNA in vitro near the respective modification sites. Sco4631 cleaves DNA at multiple possible sites on either side of the S-modification. Double-strand cleavage occurs 16-28 nucleotides away from the phosphorothioate links
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-
?
additional information
?
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-
a His-tagged derivative of ScoA3McrA cleaves S-modified DNA and also Dcm-methylated DNA in vitro near the respective modification sites. Sco4631 cleaves DNA at multiple possible sites on either side of the S-modification. Double-strand cleavage occurs 16-28 nucleotides away from the phosphorothioate links
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-
?
additional information
?
-
Tequatrovirus T4
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endonuclease IV encoded by denB of bacteriophage T4 is implicated in restriction of deoxycytidine (dC)-containing DNA in the host Escherichia coli
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-
?
additional information
?
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Tequatrovirus T4
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EndoII primarily catalyzes single-stranded nicking of DNA, 5 to 10fold less frequently double-stranded breaks are produced
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-
?
