3.1.21.2: deoxyribonuclease IV
This is an abbreviated version!
For detailed information about deoxyribonuclease IV, go to the full flat file.
Word Map on EC 3.1.21.2
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3.1.21.2
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exonuclease
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ape1
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glycosylase
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abasic
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strand
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endonucleases
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single-stranded
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nick
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uracil
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duplex
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phosphodiester
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uracil-dna
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methanesulfonate
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3'-blocking
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8-oxoguanine
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3'-phosphatase
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depurinated
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deoxyribose
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3\'-hydroxyl
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xrcc1
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diesterase
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incise
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site-containing
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base-excision
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endonucleolytic
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8-oxog
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soxrs
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ap-site
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5'-deoxyribose
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cross-complementing
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non-ltr
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repair-deficient
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exoiiis
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5'-phosphorylated
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uracil-containing
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non-long
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3'-phosphoglycolate
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asp148glu
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analysis
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pharmacology
- 3.1.21.2
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exonuclease
- ape1
- glycosylase
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abasic
- strand
- endonucleases
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single-stranded
- nick
- uracil
- duplex
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phosphodiester
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uracil-dna
- methanesulfonate
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3'-blocking
- 8-oxoguanine
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3'-phosphatase
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depurinated
- deoxyribose
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3\'-hydroxyl
- xrcc1
- diesterase
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incise
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site-containing
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base-excision
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endonucleolytic
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8-oxog
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soxrs
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ap-site
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5'-deoxyribose
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cross-complementing
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non-ltr
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repair-deficient
- exoiiis
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5'-phosphorylated
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uracil-containing
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non-long
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3'-phosphoglycolate
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asp148glu
- analysis
- pharmacology
Reaction
Endonucleolytic cleavage of ssDNA at apurinic/apyrimidinic sites to 5'-phosphooligonucleotide end-products =
Synonyms
apurinic/apyrimidinic endonuclease, coliphage T4 endonuclease II, deoxriboendonuclease, DNA-adenine-transferase, E. coli endonuclease IV, EC 3.1.4.30, End, Endo IV, endodeoxyribonuclease IV, EndoII, EndoIV, endonuclease II, endonuclease IV, exonuclease III, More, MtbEndo IV, MtbNfo, MtbXthA, Nfo, nuclease, endodeoxyribo-oder redoxyendonuclease, Rv0670, Sco4631, ScoA3McrA, T4 endonuclease IV, TthNfo, type IV methyl-dependent restriction endonuclease
ECTree
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General Information
General Information on EC 3.1.21.2 - deoxyribonuclease IV
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malfunction
metabolism
physiological function
additional information
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phenotype with reduced DNA repair activity of enzyme-deficient mutant strain BW527, overview
malfunction
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phenotype with reduced DNA repair activity of enzyme-deficient mutant strain BW527, overview
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the presence of this enzyme, which is part of the DNA base excision repair pathway, suggests that thermophiles use a mechanism similar to that used by mesophiles to deal with the large number of abasic sites that arise in their chromosomes due to the increased rates of DNA damage at elevated temperatures
metabolism
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the presence of this enzyme, which is part of the DNA base excision repair pathway, suggests that thermophiles use a mechanism similar to that used by mesophiles to deal with the large number of abasic sites that arise in their chromosomes due to the increased rates of DNA damage at elevated temperatures
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endonuclease IV recognizes and cleaves DNA on the 5' side of various oxidatively damaged bases via nucleotide incision repair (NIR)
physiological function
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endonuclease IV is the main base excision repair enzyme involved in DNA damage induced by UVA radiation and stannous chloride
physiological function
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in the nucleotide incision repair pathway, an apurinic/apyrimidinic endonuclease incises duplex DNA 5' next to oxidatively damaged nucleotide. The multifunctional Escherichia coli endonuclease IV is involved in both base excision repair and nucleotide incision repair pathways, overview
physiological function
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in vitro endonuclease activity of the Escherichia coli McrA homologue that specifically cleaves S-modified DNA
physiological function
the enzyme plays a crucial role in defense against oxidative stress
physiological function
key enzyme involved in the repair of abasic sites and DNA strand breaks
physiological function
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in vitro endonuclease activity of the Escherichia coli McrA homologue that specifically cleaves S-modified DNA
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physiological function
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key enzyme involved in the repair of abasic sites and DNA strand breaks
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physiological function
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the enzyme plays a crucial role in defense against oxidative stress
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physiological function
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endonuclease IV recognizes and cleaves DNA on the 5' side of various oxidatively damaged bases via nucleotide incision repair (NIR)
-
physiological function
-
endonuclease IV is the main base excision repair enzyme involved in DNA damage induced by UVA radiation and stannous chloride
-
physiological function
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in the nucleotide incision repair pathway, an apurinic/apyrimidinic endonuclease incises duplex DNA 5' next to oxidatively damaged nucleotide. The multifunctional Escherichia coli endonuclease IV is involved in both base excision repair and nucleotide incision repair pathways, overview
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Tequatrovirus T4
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a protruding loop containing a nuclease-associated modular domain 3 element is likely to be involved in substrate binding, as well as residues forming a separate nucleic acid binding surface adjacent to the active site. EndoII may bind its substrate inefficiently across the two sites in the dimer, offering a plausible explanation for the catalytic preponderance of single-strand nicks
additional information
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Nfo catalyzed nucleotide incision and 3'-5' exonuclease activities are genetically coupled. modeling of nucleotide incision coupled to 3'-5' exonuclease activity preventing formation of lethal double-strand breaks when repairing bi-stranded clustered DNA damage, overview
additional information
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Nfo catalyzed nucleotide incision and 3'-5' exonuclease activities are genetically coupled. modeling of nucleotide incision coupled to 3'-5' exonuclease activity preventing formation of lethal double-strand breaks when repairing bi-stranded clustered DNA damage, overview
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