3.1.11.5: exodeoxyribonuclease V
This is an abbreviated version!
For detailed information about exodeoxyribonuclease V, go to the full flat file.
Word Map on EC 3.1.11.5
Reaction
Exonucleolytic cleavage (in the presence of ATP) in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides =
Synonyms
AddAB enzyme, E. coli ATP-dependent DNase, E. coli exonuclease V, Escherichia coli exonuclease V, Escherichia coli RecBCD, Exodeoxyribonuclease V 125 kDa polypeptide, Exodeoxyribonuclease V 135 KDA polypeptide, Exodeoxyribonuclease V 67 kDa polypeptide, exonuclease V, ExoV, gene recBC DNase, gene RecBC endoenzyme, nuclease, exodeoxyribo V, PAB2263, RecB, RecB helicase-nuclease, REcB30 protein, recBC deoxyribonuclease, recBC DNase, recBC nuclease, RecBCD, RecBCD DNase, recBCD enzyme, RecBCD exonuclease, RecBCD-type helicase-nuclease, RecD, UPF0286 protein PYRAB01260
ECTree
3.1.11.5 exodeoxyribonuclease VAdvanced search results
results (
results (Inhibitors
Inhibitors on EC 3.1.11.5 - exodeoxyribonuclease V
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
top
INHIBITOR 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
IMAGE
abc protein
-
anti recBCD; binds the recBCD enzyme and inhibits recombination but not exonuclease activity; gamma-protein analog encoded by bacteriophage P22
-
bacteriophage Mu
-
induction of bacteriophage Mu causes inhibition of exonuclease V
-
ATP
-
0.2 mM and higher concentrations inhibits phosphodiester hydrolysis
ATP
-
0.2 mM and higher concentrations inhibits phosphodiester hydrolysis; neither the rate nor the extent of hydrolysis of single-stranded DNA nor ATP is affected
ATP
-
0.2 mM and higher concentrations inhibits phosphodiester hydrolysis; neither the rate nor the extent of hydrolysis of single-stranded DNA nor ATP is affected
E. coli single stranded DNA binding protein
-
ATPase activity complete inhibited by SSB
-
Gamma-protein
-
binds the recBCD enzyme and inhibits ATPase, exonuclease and endonuclease and helicase activity
-
additional information
-
The overall inhibition is length dependent, the longer the oligonucleotide the more effective the inhibition. The oligonucleotide Chi+ oligonucletides inhibit the activities of enzyme much more than do the oligonucleotides Chi0.
-
additional information
-
lambda Gam, by inhibiting host RecBCD nuclease activity, helps to improve the efficiency of lambda Red-mediated recombination with linear double-strand DNA
-
additional information
RecBCD degradation of DNA is inhibited by either cisplatin-damaged or UV-damaged DNA sequences. A DNA-targeted 9-aminoacridinecarboxamide cisplatin analogue is also found to inhibit RecBCD activity. The three different DNA damaging agents, UV light, cisplatin and 9AmAcPtCl2, are examined, all strongly inhibit the activity of RecBCD
-
additional information
the tether (amino acids 881-899 of RecB) amino-acid composition, like the tether length, can strongly affect the ability ofRecBCD to respond to Chi and to promote recombination
-
additional information
-
the tether (amino acids 881-899 of RecB) amino-acid composition, like the tether length, can strongly affect the ability ofRecBCD to respond to Chi and to promote recombination
-
