3.1.11.2: exodeoxyribonuclease III
This is an abbreviated version!
For detailed information about exodeoxyribonuclease III, go to the full flat file.
Word Map on EC 3.1.11.2
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3.1.11.2
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strand
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single-stranded
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polymerases
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duplex
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dicer
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endonucleases
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dsrnas
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bacteriophage
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proofreading
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endoribonuclease
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mismatch
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drosha
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ultrasensitive
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klenow
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nick
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stem-loop
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ssdna
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abasic
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exonucleolytic
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aptamer
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nucleases
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polynucleotide
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translesion
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dntp
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aptasensors
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argonaut
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ape1
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pri-mirnas
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misincorporation
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g-quadruplexes
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overhang
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pnpase
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exonuclease-deficient
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microprocessor
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dsrna-binding
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primase
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tetraloops
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iii-dependent
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micrococcal
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aphidicolin
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pre-rrnas
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primer-template
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dnazyme
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rna-induced
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foscarnet
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template-primer
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synthesis
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target-induced
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medicine
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rna-specific
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analysis
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molecular biology
-
okazaki
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dicer-like
- 3.1.11.2
- strand
-
single-stranded
- polymerases
- duplex
- dicer
- endonucleases
- dsrnas
- bacteriophage
-
proofreading
-
endoribonuclease
- mismatch
- drosha
-
ultrasensitive
-
klenow
- nick
-
stem-loop
- ssdna
-
abasic
-
exonucleolytic
- aptamer
- nucleases
- polynucleotide
-
translesion
- dntp
-
aptasensors
-
argonaut
- ape1
-
pri-mirnas
-
misincorporation
-
g-quadruplexes
-
overhang
- pnpase
-
exonuclease-deficient
-
microprocessor
-
dsrna-binding
- primase
- tetraloops
-
iii-dependent
-
micrococcal
- aphidicolin
- pre-rrnas
-
primer-template
- dnazyme
-
rna-induced
- foscarnet
-
template-primer
- synthesis
-
target-induced
- medicine
-
rna-specific
- analysis
- molecular biology
-
okazaki
-
dicer-like
Reaction
Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates =
Synonyms
3'-5' exonuclease, 3'-5' exonuclease III, AP endonuclease VI, AP-endonuclease/3'-5'exodeoxyribonuclease, Ape2, class II apurinic/apyrimidinic-endonuclease/3'-5' exonuclease III, class-II AP-endonuclease, DNA pol, E. coli exonuclease III, EC 3.1.4.27, Escherichia coli exonuclease III, exo III, EXO-3, exodeoxyribonuclease III, ExoIII, exonuclease III, exonuclease-3, MacExoIII, More, MtbXthA, nuclease, endoribo-, III, nuclease, Escherichia coli exo-, III, ribonuclease III, RNase III, Sso, xthA, xthA-1 gene product
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Metals Ions
Metals Ions on EC 3.1.11.2 - exodeoxyribonuclease III
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Ca2+
Mg2+
Mn2+
NaCl
MtbXthA exhibits an increase in AP site incision activity in a salt-dependent manner
additional information
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sharp optimum requirement at 1 mM for exonucleolytic and endonucleolytic activity
Ca2+
the enzyme requires the presence of Mg2+ and, to lesser extent, Ca2+ and Mn2+ for the DNA repair activity
Mg2+
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broad optimum, requirement for exonucleolytic and endonucleolytic activity
Mg2+
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required, a high concentration of Mg2+ does not inhibit enzyme nor relieve the Mn2+-dependent inhibition
Mg2+
the enzyme requires the presence of Mg2+ and, to lesser extent, Ca2+ and Mn2+ for the DNA repair activity
Mn2+
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the optimal concentration is 1 mM, while concentrations above 5 mM are inhibitory
Mn2+
the enzyme requires the presence of Mg2+ and, to lesser extent, Ca2+ and Mn2+ for the DNA repair activity. Depending on pH, the enzyme requires different concentrations of divalent cations: 0.5 mM MnCl2 at pH 7.6 and 10 mM at pH 6.5
Mn2+
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the enzyme is able to catalyze the excision of mispaired nucleotides at the 3'OH terminus of a primer/template DNA substrate in th presence of Mn2+ ion
the highly conserved catalytic site in AP endonucleases consists of residues involved in the binding of metal ions. MtbXthA exhibits moderate 3'-5' exonuclease activity at low ionic environment
additional information
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the highly conserved catalytic site in AP endonucleases consists of residues involved in the binding of metal ions. MtbXthA exhibits moderate 3'-5' exonuclease activity at low ionic environment