2.1.1.B76: flavone/flavonol 7-O-methyltransferase

This is an abbreviated version!
For detailed information about flavone/flavonol 7-O-methyltransferase, go to the full flat file.

Reaction

Synonyms

flavone 7-O-methyltransferase, flavonoid 7-O-methyltransferase, flavonoid O-methyltransferase, POMT-7, POMT7

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.B76 flavone/flavonol 7-O-methyltransferase

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Results	in table
3	Application
6	Cloned(Commentary)
2	Cofactor
1	General Information
8	kcat/KM [mM/s]
8	KM Value [mM]
4	Natural Substrates/ Products (Substrates)
5	Organism
1	pH Optimum
4	Protein Variants
2	Purification (Commentary)
6	Reaction
5	Reference
2	Source Tissue
24	Substrates and Products (Substrate)
9	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
8	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.1.1.B76 - flavone/flavonol 7-O-methyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

2 S-adenosyl-L-methionine + kaempferol

S-adenosyl-L-homocysteine + 3,7-O-dimethylkaempferol

Populus sp.

-

activity only of enzyme mutant POMT7-M1, D257G, not of wild-type POMT7

713037

-

-

?

2 S-adenosyl-L-methionine + quercetin

S-adenosyl-L-homocysteine + 3,7-O-dimethylquercetin

Populus sp.

-

activity only of enzyme mutant POMT7-M1, D257G, not of wild-type POMT7, molecular docking of quercetin into the modeled structure of Asp257Gly

713037

-

-

?

S-adenosyl-L-methionine + (2S)-5,7,4'-trihydroxyflavanone

S-adenosyl-L-homocysteine + (2S)-5,4'-dihydroxy-7-methoxyflavanone

2 entries

S-adenosyl-L-methionine + 3',4',5,7-tetrahydroxyflavanone

S-adenosyl-L-homocysteine + 3,4',5-trihydroxy-7-methoxyflavanone

Populus deltoides

-

i.e. eriodictyol, 14% of the activity with apigenin (i.e. 5,7,4'-trihydroxyflavone)

674975

-

-

?

S-adenosyl-L-methionine + 3,3',4',5,7-pentahydroxyflavone

S-adenosyl-L-homocysteine + 3,3',4',5-tetrahydroxy-7-methoxyflavone

4 entries

S-adenosyl-L-methionine + 3,4',5,7-tetrahydroxyflavanone

S-adenosyl-L-homocysteine + 3,4',5-trihydroxy-7-methoxyflavanone

2 entries

S-adenosyl-L-methionine + 3,5,7,4'-tetrahydroxy-3'-methoxyflavone

S-adenosyl-L-homocysteine + 3,5,4'-trihydroxy-7,3'-dimethoxyflavone

2 entries

S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone

S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyflavone

3 entries

S-adenosyl-L-methionine + kaempferol

S-adenosyl-L-homocysteine + 7-O-methylkaempferol

Populus sp.

-

-

713037

-

-

?

S-adenosyl-L-methionine + luteolin

S-adenosyl-L-homocysteine + 3,4',5-trihydroxy-7-methoxyflavanone

Populus deltoides

-

i.e. 5,7,3',4'-tetrahydroxyflavanone, 87% of the activity with apigenin (i.e. 5,7,4'-trihydroxyflavone)

674975

-

-

?

S-adenosyl-L-methionine + quercetin

S-adenosyl-L-homocysteine + 7-O-methylquercetin

3 entries

additional information

?

-

3 entries

S-adenosyl-L-methionine + (2S)-5,7,4'-trihydroxyflavanone

S-adenosyl-L-homocysteine + (2S)-5,4'-dihydroxy-7-methoxyflavanone

Populus deltoides

-

i.e. (2S)-naringenin, 16% of the activity with apigenin (i.e. 5,7,4'-trihydroxyflavone)

674975

i.e. (2S)-sakuranetin

-

?

S-adenosyl-L-methionine + (2S)-5,7,4'-trihydroxyflavanone

S-adenosyl-L-homocysteine + (2S)-5,4'-dihydroxy-7-methoxyflavanone

Populus deltoides Marsh

-

i.e. (2S)-naringenin, 16% of the activity with apigenin (i.e. 5,7,4'-trihydroxyflavone)

674975

i.e. (2S)-sakuranetin

-

?

S-adenosyl-L-methionine + 3,3',4',5,7-pentahydroxyflavone

S-adenosyl-L-homocysteine + 3,3',4',5-tetrahydroxy-7-methoxyflavone

Populus deltoides

-

i.e. quercetin, 98% of the activity with apigenin (i.e. 5,7,4'-trihydroxyflavone)

674975

-

-

?

S-adenosyl-L-methionine + 3,3',4',5,7-pentahydroxyflavone

S-adenosyl-L-homocysteine + 3,3',4',5-tetrahydroxy-7-methoxyflavone

Populus deltoides Marsh

-

i.e. quercetin, 98% of the activity with apigenin (i.e. 5,7,4'-trihydroxyflavone)

674975

-

-

?

S-adenosyl-L-methionine + 3,3',4',5,7-pentahydroxyflavone

S-adenosyl-L-homocysteine + 3,3',4',5-tetrahydroxy-7-methoxyflavone

Populus sp.

-

i.e. quercetin

713037

-

-

?

S-adenosyl-L-methionine + 3,3',4',5,7-pentahydroxyflavone

S-adenosyl-L-homocysteine + 3,3',4',5-tetrahydroxy-7-methoxyflavone

Populus sp.

-

i.e. quercetin

720210

i.e. rhamnetin

-

?

S-adenosyl-L-methionine + 3,4',5,7-tetrahydroxyflavanone

S-adenosyl-L-homocysteine + 3,4',5-trihydroxy-7-methoxyflavanone

Populus deltoides

-

i.e. kaempferol, 82% of the activity with apigenin (i.e. 5,7,4'-trihydroxyflavone)

674975

-

-

?

S-adenosyl-L-methionine + 3,4',5,7-tetrahydroxyflavanone

S-adenosyl-L-homocysteine + 3,4',5-trihydroxy-7-methoxyflavanone

Populus sp.

-

i.e. kaempferol

713037

-

-

?

S-adenosyl-L-methionine + 3,5,7,4'-tetrahydroxy-3'-methoxyflavone

S-adenosyl-L-homocysteine + 3,5,4'-trihydroxy-7,3'-dimethoxyflavone

Populus deltoides

-

i.e. isorhamnetin, 57% of the activity with apigenin (i.e. 5,7,4'-trihydroxyflavone)

674975

-

-

?

S-adenosyl-L-methionine + 3,5,7,4'-tetrahydroxy-3'-methoxyflavone

S-adenosyl-L-homocysteine + 3,5,4'-trihydroxy-7,3'-dimethoxyflavone

Populus deltoides Marsh

-

i.e. isorhamnetin, 57% of the activity with apigenin (i.e. 5,7,4'-trihydroxyflavone)

674975

-

-

?

S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone

S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyflavone

Populus deltoides

-

i.e. apigenin

674975

i.e. genkwanin

-

?

S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone

S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyflavone

Populus deltoides Marsh

-

i.e. apigenin

674975

i.e. genkwanin

-

?

S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone

S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyflavone

Populus sp.

-

i.e. apigenin

699499

i.e. genkwanin

-

?

S-adenosyl-L-methionine + quercetin

S-adenosyl-L-homocysteine + 7-O-methylquercetin

Populus sp.

-

-

713037

-

-

?

S-adenosyl-L-methionine + quercetin

S-adenosyl-L-homocysteine + 7-O-methylquercetin

Populus sp.

-

-

720210

i.e. rhamnetin

-

?

S-adenosyl-L-methionine + quercetin

S-adenosyl-L-homocysteine + 7-O-methylquercetin

Populus sp.

-

POMT7 has a high affinity toward quercetin

720210

i.e. rhamnetin

-

?

additional information

?

-

Populus deltoides

-

POMT-7 is able to transfer a methyl group to several flavonoids containing a C-7 hydroxyl group. POMT-7 shows a higher affinity toward flavonol and flavone such as apigenin, kaempferol, luteolin, and quercetin than flavanone and isoflavone

674975

-

-

?

additional information

?

-

Populus deltoides Marsh

-

POMT-7 is able to transfer a methyl group to several flavonoids containing a C-7 hydroxyl group. POMT-7 shows a higher affinity toward flavonol and flavone such as apigenin, kaempferol, luteolin, and quercetin than flavanone and isoflavone

674975

-

-

?

additional information

?

-

Populus sp.

-

the O-methyltransferase from poplar transfers a methyl group to several flavonoids that contain a 7-hydroxyl group. POMT7 has a high affinity toward quercetin, and the reaction product rhamnetin

720210

-

-

?