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2.1.1.B76: flavone/flavonol 7-O-methyltransferase

This is an abbreviated version!
For detailed information about flavone/flavonol 7-O-methyltransferase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
a flavone
=
S-adenosyl-L-homocysteine
+
a 7-methoxyflavone

Synonyms

flavone 7-O-methyltransferase, flavonoid 7-O-methyltransferase, flavonoid O-methyltransferase, POMT-7, POMT7

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.B76 flavone/flavonol 7-O-methyltransferase

Engineering

Engineering on EC 2.1.1.B76 - flavone/flavonol 7-O-methyltransferase

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PROTEIN VARIANTS
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
D257G
-
random mutagenesis, the mutant of POMT-7, POMT7-M1, has a novel regioselectivity, from large scale mutant screening, mutant D257G methylates the 3-hydroxyl group of flavonols in addition to 7-hydrdoxyl group
N257G
-
the mutant methylates the 3-hydroxyl group of flavonols in addition to 7-hydrdoxyl group. The wild type POMT7 exhibits better activity toward kaempferol and quercetin than the mutant enzyme
additional information