2.1.1.B75: flavonoid 7-O-methyltransferase
This is an abbreviated version!
For detailed information about flavonoid 7-O-methyltransferase, go to the full flat file.
Reaction
Synonyms
7-O-methyltransferase, CGZ69_28180, flavonoid O-methyltransferase, OMT2, POMT7, SaOMT, SaOMT-2, SAVERM_2382, SpOMT7740
ECTree
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Engineering
Engineering on EC 2.1.1.B75 - flavonoid 7-O-methyltransferase
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D257G
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random mutagenesis, the mutant of POMT-7, POMT7-M1, has a novel regioselectivity, from large scale mutant screening, mutant D257G methylates the 3-hydroxyl group of flavonols in addition to 7-hydrdoxyl group
additional information
the recombinant SaOMT is used for 7-O-methylation of naringenin in recombinantly engineered production of 7-O-methyl aromadendrin via sakuranetin from 4-coumaric acid in Escherichia coli, overview. In order to increase the availability of malonyl-CoA, a critical precursor of 7-O-methyl aromadendrin, genes for the acyl-CoA carboxylase alpha- and beta-subunits (nfa9890 and nfa9940), biotin ligase (nfa9950), and acetyl-CoA synthetase (nfa3550) from Nocardia farcinica were also introduced
additional information
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the recombinant SaOMT is used for 7-O-methylation of naringenin in recombinantly engineered production of 7-O-methyl aromadendrin via sakuranetin from 4-coumaric acid in Escherichia coli, overview. In order to increase the availability of malonyl-CoA, a critical precursor of 7-O-methyl aromadendrin, genes for the acyl-CoA carboxylase alpha- and beta-subunits (nfa9890 and nfa9940), biotin ligase (nfa9950), and acetyl-CoA synthetase (nfa3550) from Nocardia farcinica were also introduced
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