2.1.1.B74: apigenin 7-O-methyltransferase

This is an abbreviated version!
For detailed information about apigenin 7-O-methyltransferase, go to the full flat file.

Reaction

Synonyms

F1-OMT, F7OMT, flavone 7-O-methyltransferase, flavonoid 7-O-methyltransferase, flavonoid 7-OMT, POMT-7, POMT7

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.B74 apigenin 7-O-methyltransferase

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Results	in table
2	AA Sequence
1	Application
4	Cloned(Commentary)
2	Cofactor
1	General Information
2	KM Value [mM]
1	Molecular Weight [Da]
3	Natural Substrates/ Products (Substrates)
4	Organism
2	pH Optimum
1	Protein Variants
1	Purification (Commentary)
1	Reaction
4	Reference
2	Source Tissue
9	Substrates and Products (Substrate)
1	Subunits
9	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]

Substrates Products

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Substrates Products on EC 2.1.1.B74 - apigenin 7-O-methyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

S-adenosyl-L-methionine + 3',4',5,7-tetrahydroxyflavanone

S-adenosyl-L-homocysteine + 3',4',5-trihydroxy-7-methoxyflavanone

Hordeum vulgare

Q43771

i.e. eriodictyol, about 10% of the activity with 5,7,4'-trihydroxyflavone (i.e. apigenin)

643766

-

-

?

S-adenosyl-L-methionine + 3,4',5,7-tetrahydroxyflavanone

S-adenosyl-L-homocysteine + 3,4',5-trihydroxy-7-methoxyflavanone

Hordeum vulgare

Q43771

i.e. kaempferol, about 15% of the activity with 5,7,4'-trihydroxyflavone (i.e. apigenin)

643766

-

-

?

S-adenosyl-L-methionine + 5,7,3',4'-tetrahydroxyflavone

S-adenosyl-L-homocysteine + 7-methoxy-5,3',4'-tetrahydroxyflavone

Hordeum vulgare

Q43771

i.e. luteolin, about 15% of the activity with 5,7,4'-trihydroxyflavone (i.e. apigenin)

643766

-

-

?

S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavanone

S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyflavanone

Hordeum vulgare

Q43771

i.e. naringenin, about 30% of the activity with 5,7,4'-trihydroxyflavone (i.e. apigenin)

643766

i.e. sakuranetin

-

?

S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone

S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyflavone

2 entries

S-adenosyl-L-methionine + apigenin

S-adenosyl-L-homocysteine + 7-O-methylapigenin

Populus deltoides

-

-

699499, 736626

i.e. genkwanin

-

?

S-adenosyl-L-methionine + apigenin

S-adenosyl-L-homocysteine + genkwanin

Ocimum basilicum

K0I977

-

755873

-

-

?

S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone

S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyflavone

Hordeum vulgare

Q43771

i.e. apigenin. The product genkwanin exhibits a stronger inhibitory effect on the germination of spores from pathogenic fungi as compared to the effect of apigenin

643766

i.e. genkwanin

-

?

S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone

S-adenosyl-L-homocysteine + 5,4'-dihydroxy-7-methoxyflavone

Hordeum vulgare

Q43771

i.e. apigenin, sequential bi-bi mechanism

643766

i.e. genkwanin

-

?