2.1.1.99: 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase
This is an abbreviated version!
For detailed information about 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase, go to the full flat file.
Reaction
Synonyms
16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase, methyltransferase, 16-methoxy-2,3-dihydro-3-hydroxytabersonine, NMT, S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxy-tabersonine N-methyltransferase
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Substrates Products
Substrates Products on EC 2.1.1.99 - 3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + 16-methoxy-2,3-dihydro-3-hydroxytabersonine
S-adenosyl-L-homocysteine + deacetoxyvindoline
additional information
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hydrogenation of 2,3 double bond of tabersonine instead of hydration results in a 75% decrease in N-methylation, double bound present: no N-methylation, the presence of 6,7 double bound is a necessary structural requirement for N-methylation with membrane-bound enzyme, whereas the detergent-solubilized enzyme is also able to N-methylate the 6,7 anhydro analogue
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S-adenosyl-L-homocysteine + deacetoxyvindoline
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i.e. N(1)-methyl-16-methoxy-2,3-dihydro-3-hydroxytabersonine
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S-adenosyl-L-methionine + 16-methoxy-2,3-dihydro-3-hydroxytabersonine
S-adenosyl-L-homocysteine + deacetoxyvindoline
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i.e. N(1)-methyl-16-methoxy-2,3-dihydro-3-hydroxytabersonine
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S-adenosyl-L-methionine + 16-methoxy-2,3-dihydro-3-hydroxytabersonine
S-adenosyl-L-homocysteine + deacetoxyvindoline
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high degree of specificity for the N-indole of 2,3-dihydro-3-hydroxytabersonine
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S-adenosyl-L-methionine + 16-methoxy-2,3-dihydro-3-hydroxytabersonine
S-adenosyl-L-homocysteine + deacetoxyvindoline
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enzyme is involved in the biosynthesis of vindoline from tabersonine
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S-adenosyl-L-methionine + 16-methoxy-2,3-dihydro-3-hydroxytabersonine
S-adenosyl-L-homocysteine + deacetoxyvindoline
-
enzyme is involved in the biosynthesis of vindoline from tabersonine
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?
S-adenosyl-L-methionine + 16-methoxy-2,3-dihydro-3-hydroxytabersonine
S-adenosyl-L-homocysteine + deacetoxyvindoline
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enzyme is involved in the biosynthesis of vindoline from tabersonine
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