2.1.1.71: phosphatidyl-N-methylethanolamine N-methyltransferase

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For detailed information about phosphatidyl-N-methylethanolamine N-methyltransferase, go to the full flat file.

Reaction

Synonyms

class I PLMT, methyltransferase II, PE N-MTase, PEMT-L, PEMT-S, phosphatidyl-N-methylethanolamine methyltransferase, phosphatidyl-N-monomethylethanolamine methyltransferase, phosphatidylethanolamine methyltransferase I, phosphatidylethanolamine N-methyltransferase, phosphatidylmonomethylethanolamine methyltransferase, phospholipid methyltransferase, phospholipid N-methyltransferase, PLMT

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.71 phosphatidyl-N-methylethanolamine N-methyltransferase

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Results	in table
2309	AA Sequence
2	Application
1	CAS Registry Number
8	Cloned(Commentary)
13	Disease/ Diagnostics
2	Expression
3	General Information
10	Inhibitors
6	Ki Value [mM]
12	KM Value [mM]
25	Localization
3	Metals/Ions
3	Molecular Weight [Da]
355	Organism
8	Pathway
10	pH Optimum
4	pH Range
1	Posttranslational Modification
2	Purification (Commentary)
1	Reaction
1	Reaction Type
25	Reference
25	Source Tissue
2	Specific Activity [micromol/min/mg]
2	Storage Stability
32	Substrates and Products (Substrate)
17	Synonyms
1	Systematic Name
2	Temperature Optimum [°C]
1	Temperature Stability [°C]

General Information

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General Information on EC 2.1.1.71 - phosphatidyl-N-methylethanolamine N-methyltransferase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

metabolism

Homo sapiens

-

PEMT-L and PEMT-S expression increase the cellular phosphatidylcholine content, whereas the phosphatidylethanolamine content is decreased by PEMT-S expression, but is hardly affected by PEMT-L expression. The cellular content of phosphatidylserine is also reduced by the expression of PEMT-L or PEMT-S

718778

physiological function

2 entries

physiological function

Arabidopsis thaliana

Q9SAH5

although the accumulation of the PLMT substrates phosphatidyl-N-monomethylethanolamine and phosphatidyl-N,N-dimethylethanolamine is considerably elevated in the plmt knock-out line, phosphatidylcholine levels remain normal, and no obvious differences are observed in plant morphology or development under standard growth conditions

704482

physiological function

Homo sapiens

-

PEMT-L and PEMT-S expression promote the proliferation of HEK-293 cells

718778