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2.1.1.64: 3-demethylubiquinol 3-O-methyltransferase

This is an abbreviated version!
For detailed information about 3-demethylubiquinol 3-O-methyltransferase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
3-demethylubiquinol-n
=
S-adenosyl-L-homocysteine
+
ubiquinol-n

Synonyms

2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase, 5-demethylubiquinone-9 methyltransferase, 5-demethylubiquinone-9-methyltransferase, AtCOQ3, COQ3, Coq3 O-methyltransferase, O-methyltransferase, OMHMB methyltransferase, OMHMB-methyltransferase, S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase, UbiG, UbiG methyltransferase, ubiquinone biosynthesis O-methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.64 3-demethylubiquinol 3-O-methyltransferase

Cloned

Cloned on EC 2.1.1.64 - 3-demethylubiquinol 3-O-methyltransferase

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CLONED (Commentary)
ORGANISM
UNIPROT
LITERATURE
AtCOQ3 is able to restore the respiration ability and ubiquinone synthesis of the coq3 deletion mutant of Saccharomyces cerevisiae
His6-tagged enzyme is expressed in Escherichia coli BL21(DE3) cells
-
rat COQ3 gene restores O-methyltransferase activity in coq3 null mutant yeast
the rescue of the yeast coq3 mutant by the rat homologue suggests that yeast and rat synthesize ubiquinone via the same early steps in this pathway
the ubiG gene is able to restore respiration in the yeast coq3 mutant, provided ubiG is modified to contain a mitochondrial leader sequence
-
when expressed in multicopy, the human construct rescues the growth of a yeast coq3 null mutant on a nonfermentable carbon source and restores coenzyme Q biosynthesis, although at lower levels than that of wild type yeast