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2.1.1.62: mRNA (2'-O-methyladenosine-N6-)-methyltransferase

This is an abbreviated version!
For detailed information about mRNA (2'-O-methyladenosine-N6-)-methyltransferase, go to the full flat file.

Reaction

S-adenosyl-L-methionine
+
a 5-(N7-methyl 5-triphosphoguanosine)-2'-O-methyladenosine-[mRNA]
=
S-adenosyl-L-homocysteine
+
a 5-(N7-methyl 5-triphosphoguanosine)-N6,2'-O-dimethyladenosine-[mRNA]

Synonyms

cap-dependent 2'-O-methyltransferase, messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase, mRNA cap (nucleoside-2'O)-methyltransferase, NS5MTaseDV, VP39

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.62 mRNA (2'-O-methyladenosine-N6-)-methyltransferase

Reference

Reference on EC 2.1.1.62 - mRNA (2'-O-methyladenosine-N6-)-methyltransferase

Please use the Reference Search for a specific query.
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REF.
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Keith, J.M.; Ensinger, M.J.; Moss, B.
HeLa cell RNA (2-O-methyladenosine-N6-)-methyltransferase specific for the capped 5-end of messenger RNA
J. Biol. Chem.
253
5033-5041
1978
Homo sapiens
Manually annotated by BRENDA team
Shivakumar, A.G.; Dubnau, D.
Characterization of a plasmid-specified ribosome methylase associated with macrolide resistance
Nucleic Acids Res.
9
2549-2562
1981
Staphylococcus aureus
Manually annotated by BRENDA team
Shi, X.; Yao, P.; Jose, T.; Gershon, P.D.
Methyltransferase-specific domains within VP39, a bifunctional protein that participates in the modification of both mRNA ends
RNA
2
88-101
1996
Variola sp.
Manually annotated by BRENDA team
Luzhkov, V.B.; Selisko, B.; Nordqvist, A.; Peyrane, F.; Decroly, E.; Alvarez, K.; Karlen, A.; Canard, B.; Qvist, J.
Virtual screening and bioassay study of novel inhibitors for dengue virus mRNA cap (nucleoside-2O)-methyltransferase
Bioorg. Med. Chem.
15
7795-7802
2007
Dengue virus
Manually annotated by BRENDA team