2.1.1.62: mRNA (2'-O-methyladenosine-N6-)-methyltransferase

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For detailed information about mRNA (2'-O-methyladenosine-N6-)-methyltransferase, go to the full flat file.

Reaction

a 5-(N7-methyl 5-triphosphoguanosine)-2'-O-methyladenosine-[mRNA]

a 5-(N7-methyl 5-triphosphoguanosine)-N6,2'-O-dimethyladenosine-[mRNA]

Synonyms

cap-dependent 2'-O-methyltransferase, messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase, mRNA cap (nucleoside-2'O)-methyltransferase, NS5MTaseDV, VP39

ECTree

2 Transferases

2.1 Transferring one-carbon groups

2.1.1 Methyltransferases

2.1.1.62 mRNA (2'-O-methyladenosine-N6-)-methyltransferase

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Results	in table
1	Activating Compound
143	AA Sequence
1	CAS Registry Number
1	Cloned(Commentary)
1	Cofactor
2	Disease/ Diagnostics
1	IC50 Value
1	Inhibitors
1	Localization
2	Molecular Weight [Da]
1	Natural Substrates/ Products (Substrates)
4	Organism
32	PDB ID
2	Purification (Commentary)
1	Reaction
1	Reaction Type
4	Reference
1	Specific Activity [micromol/min/mg]
2	Storage Stability
8	Substrates and Products (Substrate)
1	Subunits
5	Synonyms
1	Systematic Name

Natural Substrates Products

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Natural Substrates Products on EC 2.1.1.62 - mRNA (2'-O-methyladenosine-N6-)-methyltransferase

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S-adenosyl-L-methionine + m7G(5')pppAm-mRNA

S-adenosyl-L-homocysteine + m7G(5')pppm6Am-mRNA

Homo sapiens

involved in post-transcriptional modification of 5'-end of messenger-RNA

485483

mRNA containing an N6,2'-O-dimethyladenosine cap

485483