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2.1.1.56: mRNA (guanine-N7)-methyltransferase

This is an abbreviated version!
For detailed information about mRNA (guanine-N7)-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.56

Reaction

S-adenosyl-L-methionine
+
a 5'-(5'-triphosphoguanosine)-[mRNA]
=
S-adenosyl-L-homocysteine
 +
a 5'-(N7-methyl 5'-triphosphoguanosine)-[mRNA]

Synonyms

(guanine-N7)-methyltransferase, Abd1, alphavirus capping enzyme, cap methyltransferase, cap N7-MTase, cap N7MTase, cap-methyltransferase, DENV methyltransferase, DENV-4 NS5, Ecm1, guanine-7-methyltransferase, guanine-N-7 methyltransferase, guanine-N7 methyltransferase, guanosine-7-methyltransferase, messenger ribonucleate guanine 7-methyltransferase, messenger RNA guanine 7-methyltransferase, methyltransferase domain of Sudan ebolavirus L protein, methyltransferase, messenger ribonucleate guanine 7-, mRNA cap (guanine N-7) methyltransferase, mRNA cap (guanine N-7) MTase, mRNA cap (guanine-N7) methyltransferase, mRNA cap methyltransferase, mRNA guanosine cap by RNA guanine-7-methyltransferase, MTase+CTD, N-7-MTase, N7 methyltransferase, N7 MTase, N7-methyltransferase, N7-MTase, non-structural protein 1, nonstructural protein 14, nonstructural protein 5 methyltransferase, NS5, NS5MTase, nsp 14, nsP1 methyltransferase, nsP1 MTase, nsp14, RNA (guanine-N7) methyltransferase, RNA cap (guanine N-7) methyltransferase, RNA guanine-7 methyltransferase, RNA guanine-7-methyltransferase, RNA guanine-methyltransferase, RNA guanine-N7 methyltransferase, RNA N7-MTase, RNMT, TbCgm1, TbCmt1

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.56 mRNA (guanine-N7)-methyltransferase

Inhibitors

Inhibitors on EC 2.1.1.56 - mRNA (guanine-N7)-methyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
(2-[4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl]ethoxy)acetic acid
-
-
(2R,6S)-2,6-dimethyl-4-[2-methyl-3-[4-(2-methylbutan-2-yl)phenyl]propyl]morpholine
-
-
1,8-dihydroxyanthracen-9(10H)-one
1-(4-tert-butylphenyl)-N-methyl-N-[(naphthalen-1-yl)methyl]methanamine
1-(diphenylmethyl)-4-methylpiperazine hydrochloride (1:1)
-
-
1-(diphenylmethyl)-4-[(2E)-3-phenylprop-2-en-1-yl]piperazine
1-[(4-chlorophenyl)(phenyl)methyl]-4-methylpiperazine
-
-
1-[(4-chlorophenyl)(phenyl)methyl]-4-[(3-methylphenyl)methyl]piperazine
1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine
1-[bis(4-fluorophenyl)methyl]-4-[(2Z)-3-phenylprop-2-en-1-yl]piperazine
2,3,7,8-tetrahydroxy[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione
-
-
2-(2-[4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl]ethoxy)ethan-1-ol
-
-
3,3',4',5,5',7-hexahaxdroxyflavone
3,3',4',5,7-pentahydroxyflavone
3,4',5,7-tetrahydroxyflavone
3,8-diamino-5-[3-[diethyl(methyl)azaniumyl]propyl]-6-phenylphenanthridin-5-ium
3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonate
-
i.e. CHAPS, strong inhibition
5',N8-Adenosyl-alpha,beta-diaminobutyric acid
-
moderate
amino acid modified structure analogue of adenosyl-L-homocysteine
-
i.e. A9145C, strong
-
aurintricarboxylic acid
aza-S-adenosyl-L-methionine
-
bis[6-(dimethylamino)-2-[(E)-2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methylquinolin-1-ium] 4-[(3-carboxy-2-oxidonaphthalen-1-yl)methyl]-3-hydroxynaphthalene-2-carboxylate
carbocyclic aza-S-adenosyl-L-methionine
-
Cd2+
about 17 % residual activity at 5 mM
Co2+
about 20 % residual activity at 5 mM
cycloheximide
-
inhibits protein synthesis in infected BHK cells
deoxycholate
-
inactivation
Digitonin
-
strong inhibition
EDTA
12% residual activity at 5 mM
GpppG
-
inhibits binding of the enzyme to RNA
N,N-bis-(3-D-gluconamidopropyl)-deoxycholamide
-
strong inhibition
N-(2-[[(4-methoxyphenyl)methyl](pyrimidin-2-yl)amino]ethyl)-N,N-dimethylhexadecan-1-aminium
n-octyl-beta-D-gluconpyranoside
-
i.e. octylglucoside, strong inhibition
N-tetradecyl-N,N-dimethyl-3-ammonio-1-propane sulfonate
-
i.e. zwittergent 3-14, strong inhibition
Ni2+
about 25 % residual activity at 5 mM
Oligoadenylic acid mono- and triphosphates
-
S-(2-azaadenosyl)-L-homocysteine
-
moderate
S-(3-Aminoadenosyl)-L-homocysteine
-
weak
S-(3-deazaadenosyl)-L-homocysteine
S-(8-azaadenosyl)-L-homocysteine
S-(N6-Dimethyl-3-deazaadenosyl)-L-homocysteine
-
weak
S-(N6-Methyladenosyl)-L-homocysteine
S-Adenosyl-D-homocysteine
S-adenosyl-homocysteine
-
-
S-adenosyl-L-cysteine
S-adenosyl-L-homocysteine
S-Adenosyl-L-homocysteine structural analogues
S-Adenosyl-L-homocysteine sulfone
S-adenosyl-L-homocysteine sulfoxide
S-Aristeromycinyl-L-homocysteine
S-Inosyl-L-homocysteine
-
weak
S-Tubercidinyl-L-homocysteine
sinefungin
Thesit
-
strong inhibition
-
Triton X-100
-
inactivation, reversible by addition of lipids: cardiolipin, phosphatidylglycerol, and especially phosphatidylserine
additional information
-