2.1.1.56: mRNA (guanine-N7)-methyltransferase

This is an abbreviated version!
For detailed information about mRNA (guanine-N7)-methyltransferase, go to the full flat file.

Reaction

Synonyms

(guanine-N7)-methyltransferase, Abd1, alphavirus capping enzyme, cap methyltransferase, cap N7-MTase, cap N7MTase, cap-methyltransferase, DENV methyltransferase, DENV-4 NS5, Ecm1, guanine-7-methyltransferase, guanine-N-7 methyltransferase, guanine-N7 methyltransferase, guanosine-7-methyltransferase, messenger ribonucleate guanine 7-methyltransferase, messenger RNA guanine 7-methyltransferase, methyltransferase domain of Sudan ebolavirus L protein, methyltransferase, messenger ribonucleate guanine 7-, mRNA cap (guanine N-7) methyltransferase, mRNA cap (guanine N-7) MTase, mRNA cap (guanine-N7) methyltransferase, mRNA cap methyltransferase, mRNA guanosine cap by RNA guanine-7-methyltransferase, MTase+CTD, N-7-MTase, N7 methyltransferase, N7 MTase, N7-methyltransferase, N7-MTase, non-structural protein 1, nonstructural protein 14, nonstructural protein 5 methyltransferase, NS5, NS5MTase, nsp 14, nsP1 methyltransferase, nsP1 MTase, nsp14, RNA (guanine-N7) methyltransferase, RNA cap (guanine N-7) methyltransferase, RNA guanine-7 methyltransferase, RNA guanine-7-methyltransferase, RNA guanine-methyltransferase, RNA guanine-N7 methyltransferase, RNA N7-MTase, RNMT, TbCgm1, TbCmt1

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.56 mRNA (guanine-N7)-methyltransferase

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Results	in table
5	Activating Compound
7217	AA Sequence
7	Application
1	CAS Registry Number
38	Cloned(Commentary)
4	Cofactor
4	Crystallization (Commentary)
952	Disease/ Diagnostics
7	General Information
4	General Stability
44	IC50 Value
128	Inhibitors
2	kcat/KM [mM/s]
15	Ki Value [mM]
31	KM Value [mM]
19	Localization
12	Metals/Ions
19	Molecular Weight [Da]
24	Natural Substrates/ Products (Substrates)
91	Organism
1	Pathway
194	PDB ID
16	pH Optimum
2	pH Range
2	pH Stability
315	Protein Variants
26	Purification (Commentary)
14	Reaction
1	Reaction Type
62	Reference
26	Source Tissue
4	Specific Activity [micromol/min/mg]
8	Storage Stability
131	Substrates and Products (Substrate)
19	Subunits
76	Synonyms
1	Systematic Name
19	Temperature Optimum [°C]
2	Temperature Range [°C]
22	Turnover Number [1/s]

General Information

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General Information on EC 2.1.1.56 - mRNA (guanine-N7)-methyltransferase

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GENERAL INFORMATION

ORGANISM

UNIPROT

COMMENTARY

LITERATURE

malfunction

3 entries

metabolism

Homo sapiens

O43148

the enzyme in complex with RNMT-activating miniprotein catalyzes the formation of a N7-methylated guanosine cap structure on the 5' end of nascent RNA polymerase II transcripts. The mRNA cap protects the primary transcript from exonucleases and recruits cap binding complexes that mediate RNA processing, export and translation

757862

physiological function

3 entries

malfunction

Dengue virus

-

mutation defective in N-7 methylation but not 2-O'-methylation is lethal for DNV replication

721100

malfunction

Homo sapiens

-

significant loss of RNA polymerase II gene occupancy is observed on enzyme suppression. Enzyme suppression inhibits transcriptional markers including histone H2BK120 ubiquitination, H3K4 and H3K36 methylation, RNA polymerase II C-terminal domain S5 and S2 phosphorylation, and PAFc recruitment

756401

malfunction

Homo sapiens

-

when cellular enzyme activity is experimentally reduced by 50%, the proliferation rate of nontransformed mammary epithelial cells is unchanged, whereas a subset of breast cancer cell lines exhibit reduced proliferation and increased apoptosis

757896

physiological function

Homo sapiens

-

mRNA guanosine cap by RNA guanine-7-methyltransferase is rate-limiting for cellular cap-methyltransferase activity, and enhancing this activity promotes cyclin D1 expression and cell formation

706020

physiological function

West Nile virus

-

N7 cap methylation is essential for viral replication

705423

physiological function

Homo sapiens

-

the enzyme promotes RNA polymerase II-dependent transcription independent of mRNA capping and translation

756401