2.1.1.5: betaine-homocysteine S-methyltransferase

This is an abbreviated version!
For detailed information about betaine-homocysteine S-methyltransferase, go to the full flat file.

Reaction

Synonyms

betaine homocysteine methyltransferase, betaine homocysteine methyltransferase-1, betaine homocysteine S-methyltransferase, betaine-homocysteine methyltransferase, betaine-homocysteine S-methyltransferase, betaine-homocysteine S-methyltransferase 2, betaine-homocysteine S-methyltransferase-2, betaine-homocysteine transmethylase, betaine:homocysteine methyltransferase, betaine:homocysteine S-methyltransferase, BHMT, BHMT-1, BHMT-2, BHMT1, BHMT2, methyltransferase, betaine-homocysteine

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.5 betaine-homocysteine S-methyltransferase

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Results	in table
28	Activating Compound
724	AA Sequence
25	Application
1	CAS Registry Number
10	Cloned(Commentary)
7	Crystallization (Commentary)
168	Disease/ Diagnostics
6	Expression
7	General Information
8	General Stability
14	IC50 Value
100	Inhibitors
4	kcat/KM [mM/s]
3	Ki Value [mM]
58	KM Value [mM]
12	Localization
11	Metals/Ions
14	Molecular Weight [Da]
4	Natural Substrates/ Products (Substrates)
311	Organism
1	Oxidation Stability
8	Pathway
16	PDB ID
10	pH Optimum
1	pH Stability
1	pI Value
1	Posttranslational Modification
60	Protein Variants
11	Purification (Commentary)
4	Reaction
1	Reaction Type
89	Reference
105	Source Tissue
13	Specific Activity [micromol/min/mg]
6	Storage Stability
50	Substrates and Products (Substrate)
12	Subunits
78	Synonyms
1	Systematic Name
5	Temperature Optimum [°C]
1	Temperature Stability [°C]
37	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.1.1.5 - betaine-homocysteine S-methyltransferase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

L-homocysteine + betaine

L-methionine + dimethylglycine

2 entries

N,N,N-trimethylglycine + L-homocysteine

N,N-dimethylglycine + L-methionine

2 entries

L-homocysteine + betaine

L-methionine + dimethylglycine

Rattus norvegicus

-

reduced BHMT activity in cirrhotic livers may explain the elevated plasma homocysteine levels in cirrhosis

658186

-

-

?

L-homocysteine + betaine

L-methionine + dimethylglycine

Sus scrofa

-

the enzyme can be modified by tissue-type transglutaminase and its activity is regulated repressively by the modification, especially by the cross-linking. This regulatory reaction might be involved in the regulation of homocysteine metabolism in the liver

658928

-

-

?

N,N,N-trimethylglycine + L-homocysteine

N,N-dimethylglycine + L-methionine

Macaca mulatta

-

enzyme cristallin in lens

441244

-

-

?

N,N,N-trimethylglycine + L-homocysteine

N,N-dimethylglycine + L-methionine

Rattus norvegicus

-

i.e. betaine, involved in betaine metabolism

441233

-

-

?