2.1.1.5: betaine-homocysteine S-methyltransferase
This is an abbreviated version!
For detailed information about betaine-homocysteine S-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.5
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2.1.1.5
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cystathionine
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s-adenosylmethionine
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choline
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folate
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remethylation
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hyperhomocysteinemia
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s-adenosylhomocysteine
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adenosyltransferase
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n-methyltransferase
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one-carbon
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beta-synthase
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dimethylglycine
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transsulfuration
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methylenetetrahydrofolate
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5-methyltetrahydrofolate-homocysteine
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transmethylation
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medicine
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mthfd1
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guanidinoacetate
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homocysteine-induced
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folate-dependent
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homocystinuria
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5-methyltetrahydrofolate
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transcobalamin
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b-vitamins
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slc19a1
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hypotaurine
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molecular biology
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analysis
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nutrition
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food industry
- 2.1.1.5
- cystathionine
- s-adenosylmethionine
- choline
- folate
-
remethylation
- hyperhomocysteinemia
- s-adenosylhomocysteine
-
adenosyltransferase
- n-methyltransferase
-
one-carbon
- beta-synthase
- dimethylglycine
-
transsulfuration
- methylenetetrahydrofolate
-
5-methyltetrahydrofolate-homocysteine
-
transmethylation
- medicine
- mthfd1
- guanidinoacetate
-
homocysteine-induced
-
folate-dependent
- homocystinuria
- 5-methyltetrahydrofolate
-
transcobalamin
-
b-vitamins
-
slc19a1
- hypotaurine
- molecular biology
- analysis
- nutrition
- food industry
Reaction
Synonyms
betaine homocysteine methyltransferase, betaine homocysteine methyltransferase-1, betaine homocysteine S-methyltransferase, betaine-homocysteine methyltransferase, betaine-homocysteine S-methyltransferase, betaine-homocysteine S-methyltransferase 2, betaine-homocysteine S-methyltransferase-2, betaine-homocysteine transmethylase, betaine:homocysteine methyltransferase, betaine:homocysteine S-methyltransferase, BHMT, BHMT-1, BHMT-2, BHMT1, BHMT2, methyltransferase, betaine-homocysteine
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General Information
General Information on EC 2.1.1.5 - betaine-homocysteine S-methyltransferase
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physiological function
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betaine homocysteine methyltransferase is a potential cargo-based end-point marker for macroautophagy
physiological function
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in blastocysts, mean inner cell numbers decrease from18-19 in controls to 11-13 when the folate cycle is inhibited by the antifolate methotrexate and to 12-14 when BHMT expression is knocked down by antisense morpholinos. Inhibiting both pathways more severely affects inner cellmass development (7-8 cells).Total SAM levels in mouse blastocysts decrease significantly only when both pathways are inhibited (from 3.1 to 1.6 pmol/100 blastocysts). DNA methylation is minimally affected by inhibition of either pathway alone but decreases by at least 45-55% when both BHMT and the folate cycle are inhibited simultaneously
physiological function
in hybernating bats, homocysteine level does not elevate in brains, despite declining vitamin B levels. At low levels of vitamin B6 and B12, no change in total expression level of methionine synthase and cystathionine beta-synthase is found, but a 1.85fold increase in the expression of the coenzyme-independent betaine-homocysteine S-methyltransferase
physiological function
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high-fat-diet-pretreated mice fed with no-added zinc diet for 4 weeks have the lowest gene and protein expression of betaine homocysteine-S-methyltransferase, cystathionine beta-synthase, and zinc-dependent transcription factor Sp1, compared with control diet or low-fat-diet pretreatment
physiological function
identification of interactions of betaine homocysteine S-methyltransferase in normal liver. S-methylmethionine homocysteine methyltransferase or betaine homocysteine methyltransferase 2, methionine adenosyltransferases alpha1 and alpha2, cAMP-dependent protein kinase catalytic subunit alpha, 4-hydroxyphenylpyruvic acid dioxygenase and aldolase b. Network analysis identified 122 nodes and 165 edges, as well as a limited number of KEGG pathways that comprise the biosynthesis of amino acids, cysteine and methionine metabolism, the spliceosome and metabolic pathways
physiological function
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in rats fed methionine and choline-deficient diet, betaine supplementation reverses the reduction of methionine and S-adenosylmethionine, and the elevation of homocysteine levels in the liver, due to the induction of betaine-homocysteine methyltransferase and methionine adenosyltransferase MAT