2.1.1.41: sterol 24-C-methyltransferase
This is an abbreviated version!
For detailed information about sterol 24-C-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.41
-
2.1.1.41
-
ergosterol
-
leishmaniasis
-
lanosterol
-
infantum
-
medicine
-
tomatidine
-
24-alkyl
-
drug development
-
24-ethyl
-
c24-methylation
-
agriculture
-
c1-transfer
-
degradation
- 2.1.1.41
- ergosterol
- leishmaniasis
- lanosterol
- infantum
- medicine
- tomatidine
-
24-alkyl
- drug development
-
24-ethyl
-
c24-methylation
- agriculture
-
c1-transfer
- degradation
Reaction
Synonyms
(S)-adenosyl-L-methionine:DELTA24(25)-sterol methyl transferase, 24-C-sterol methyltransferase, 24-SMT, 24-sterol C-methyltransferase, C-24 sterol methyltransferase, C24-methyltransferase, DELTA(24,25)-SMT, DELTA24-methyltransferase, DELTA24-sterol methyltransferase, Erg6, Erg6p, LMJF_36_2380, LMJF_36_2390, methyltransferase, DELTA24-sterol, PbSMT, phytosterol methyltransferase, S-adenosyl-4-methionine:sterol DELTA24-methyltransferase, S-adenosyl-L-methionine:DELTA24(23)-sterol methyltransferase, SAM:SMT, SMT, SMT protein, SMT1, SMT80, SMT90, sterol 24-C-methyltransferase, sterol C24-methyltransferase, sterol methyltransferase, STM, TbSMT, zymosterol 24-methyltransferase, zymosterol-24-methyltransferase
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Reference on EC 2.1.1.41 - sterol 24-C-methyltransferase
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Moore, J.T.; Gaylor, J.L.
Isolation and purification of an S-adenosylmethionine: delta 24-sterol methyltransferase from yeast
J. Biol. Chem.
244
6334-6340
1969
Saccharomyces cerevisiae
Ator, M.A.; Schmidt, S.J.; Adams, J.L.; Dolle, R.E.
Mechanism and inhibition of delta 24-sterol methyltransferase from Candida albicans and Candida tropicalis
Biochemistry
28
9633-9640
1989
Candida albicans, Candida tropicalis
Oelschlager, A.C.; Angus, R.H.; Pierce, A.M.; Pierce, H.D.; Srinivasan, R.
Azasterol inhibition of delta 24-sterol methyltransferase in Saccharomyces cerevisiae
Biochemistry
23
3582-3589
1984
Saccharomyces cerevisiae
Bansal, S.K.; Knoche, H.W.
Sterol methyltransferase from Uromyces phaseoli: an investigation of the first and the second transmethylation reactions
Phytochemistry
20
1269-1277
1981
Uromyces phaseoli
-
Lin, H.K.; Knoche, H.W.
A sterol methyltransferase from bean rust uredospores Uromyces phaseoli
Phytochemistry
15
683-687
1976
Uromyces phaseoli
-
Bailey, R.B.; Thompson, E.D.; Parks, L.W.
Kinetic properties od S-adenosyl-L-methionine:24DELTA-sterol methyltransferase enzyme(s) in mitochondrial structures of Saccharomyces cerevisiae
Biochim. Biophys. Acta
334
127-136
1974
Saccharomyces cerevisiae
-
Mukhtar, H.; Hakkou, A.; Bonaly, R.
Studies on the activity of Kluyveromyces lactis S-adenosylmethionine:DELTA 24-sterol methyltransferase in presence of polyenic antifungal agents
Mycopathologia
126
75-83
1994
Kluyveromyces lactis
Nes, W.D.
Sterol methyl transferase: enzymology and inhibition
Biochim. Biophys. Acta
1529
63-88
2000
Saccharomyces cerevisiae, Candida albicans
Venkatramesh, M.; Guo, D.A.; Jia, Z.; Nes, W.D.
Mechanism and structural requirements for transformation of substrates by the (S)-adenosyl-L-methionine:DELTA24(25)-sterol methyl transferase from Saccharomyces cerevisiae
Biochim. Biophys. Acta
1299
313-324
1996
Saccharomyces cerevisiae
Nes, W.D.; Guo, D.a.; Zhou, W.
Substrate-based inhibitors of the (S)-adenosyl-L-methionine: DELTA24(25)- to DELTA24(28)-sterol methyltransferase from Saccharomyces cerevisiae
Arch. Biochem. Biophys.
342
68-81
1997
Saccharomyces cerevisiae
Nes, W.D.; McCourt, B.S.; Zhou, W.X.; Ma, J.; Marshall, J.A.; Peek, L.A.; Brennan, M.
Overexpression, purification, and stereochemical studies of the recombinant (S)-adenosyl-L-methionine: DELTA24(25)-to DELTA24(28)-sterol methyl transferase enzyme from Saccharomyces cerevisiae
Arch. Biochem. Biophys.
353
297-311
1998
Saccharomyces cerevisiae
Kaneshiro, E.S.; Rosenfeld, J.A.; Basselin-Eiweida, M.; Stringer, J.R.; Keely, S.P.; Smulian, A.G.; Giner, J.L.
The Pneumocystis carinii drug target s-adenosyl-L-methionine:Sterol C-24 methyl transferase has a unique substrate preference
Mol. Microbiol.
44
989-999
2002
Pneumocystis carinii
Acuna-Johnson, A.P.; Oehlschlager, A.C.; Pierce, A.M.; Pierce, H.D., Jr.; Czyzewska, E.K.
Stereochemistry of yeast DELTA24-sterol methyl transferase
Bioorg. Med. Chem.
5
821-832
1997
Saccharomyces cerevisiae
Nes, W.D.; Marshall, J.A.; Jia, Z.; Jaradat, T.T.; Song, Z.; Jayasimha, P.
Active site mapping and substrate channeling in the sterol methyltransferase pathway
J. Biol. Chem.
277
42549-42556
2002
Saccharomyces cerevisiae
Visbal, G.; Alvarez, A.; Moreno, B.; San-Blas, G.
S-adenosyl-L-methionine inhibitors DELTA24-sterol methyltransferase and DELTA24(28)-sterol methylreductase as possible agents against Paracoccidioides brasiliensis
Antimicrob. Agents Chemother.
47
2966-2970
2003
Paracoccidioides brasiliensis
Nes, W.D.; Jayasimha, P.; Zhou, W.; Kanagasabai, R.; Jin, C.; Jaradat, T.T.; Shaw, R.W.; Bujnicki, J.M.
Sterol methyltransferase: functional analysis of highly conserved residues by site-directed mutagenesis
Biochemistry
43
569-576
2004
Saccharomyces cerevisiae
Mo, C.; Valachovic, M.; Bard, M.
The ERG28-encoded protein, Erg28p, interacts with both the sterol C-4 demethylation enzyme complex as well as the late biosynthetic protein, the C-24 sterol methyltransferase (Erg6p)
Biochim. Biophys. Acta
1686
30-36
2004
Saccharomyces cerevisiae
Gros, L.; Castillo-Acosta, V.M.; Jimenez, C.J.; Sealey-Cardona, M.; Vargas, S.; Estevez, A.M.; Yardley, V.; Rattray, L.; Croft, S.L.; Ruiz-Perez, L.M.; Urbina, J.A.; Gilbert, I.H.; Gonzalez-Pacanowska, D.
New azasterols against Trypanosoma brucei: role of 24-sterol methyltransferase in inhibitor action
Antimicrob. Agents Chemother.
50
2595-2601
2006
Trypanosoma brucei rhodesiense, Trypanosoma brucei brucei (Q45KX5), Trypanosoma brucei rhodesiense STIB900, Trypanosoma brucei brucei 427 (Q45KX5)
Nes, W.D.
Enzyme redesign and interactions of substrate analogues with sterol methyltransferase to understand phytosterol diversity, reaction mechanism and the nature of the active site
Biochem. Soc. Trans.
33
1189-1196
2005
Saccharomyces cerevisiae, Candida albicans, Fusarium sp., Trypanosoma brucei
Zhou, W.; Lepesheva, G.I.; Waterman, M.R.; Nes, W.D.
Mechanistic analysis of a multiple product sterol methyltransferase implicated in ergosterol biosynthesis in Trypanosoma brucei
J. Biol. Chem.
281
6290-6296
2006
Trypanosoma brucei
Nes, W.D.; Jayasimha, P.; Song, Z.
Yeast sterol C24-methyltransferase: role of highly conserved tyrosine-81 in catalytic competence studied by site-directed mutagenesis and thermodynamic analysis
Arch. Biochem. Biophys.
477
313-323
2008
Saccharomyces cerevisiae
Ganapathy, K.; Jones, C.W.; Stephens, C.M.; Vatsyayan, R.; Marshall, J.A.; Nes, W.D.
Molecular probing of the Saccharomyces cerevisiae sterol 24-C methyltransferase reveals multiple amino acid residues involved with C2-transfer activity
Biochim. Biophys. Acta
1781
344-351
2008
Saccharomyces cerevisiae, Saccharomyces cerevisiae (P25087)
Jayasimha, P.; Nes, W.D.
Photoaffinity labeling and mutational analysis of 24-C-sterol methyltransferase defines the AdoMet binding site
Lipids
43
681-693
2008
Saccharomyces cerevisiae
Jimenez-Jimenez, C.; Carrero-Lerida, J.; Sealey-Cardona, M.; Ruiz Perez, L.M.; Urbina, J.A.; Gonzalez Pacanowska, D.
Delta24(25)-sterol methenyltransferase: intracellular localization and azasterol sensitivity in Leishmania major promastigotes overexpressing the enzyme
Mol. Biochem. Parasitol.
160
52-59
2008
Leishmania major
Goto, Y.; Bogatzki, L.Y.; Bertholet, S.; Coler, R.N.; Reed, S.G.
Protective immunization against visceral leishmaniasis using Leishmania sterol 24-C-methyltransferase formulated in adjuvant
Vaccine
25
7450-7458
2007
Leishmania infantum, Leishmania infantum (A4IDL2)
Nes, W.D.; Zhou, W.; Ganapathy, K.; Liu, J.; Vatsyayan, R.; Chamala, S.; Hernandez, K.; Miranda, M.
Sterol 24-C-methyltransferase: an enzymatic target for the disruption of ergosterol biosynthesis and homeostasis in Cryptococcus neoformans
Arch. Biochem. Biophys.
481
210-218
2009
Cryptococcus neoformans, Cryptococcus neoformans 76484
Renard, D.; Perruchon, J.; Giera, M.; Mueller, J.; Bracher, F.
Side chain azasteroids and thiasteroids as sterol methyltransferase inhibitors in ergosterol biosynthesis
Bioorg. Med. Chem.
17
8123-8137
2009
Yarrowia lipolytica
Goto, Y.; Bhatia, A.; Raman, V.S.; Vidal, S.E.; Bertholet, S.; Coler, R.N.; Howard, R.F.; Reed, S.G.
Leishmania infantum sterol 24-c-methyltransferase formulated with MPL-SE induces cross-protection against L. major infection
Vaccine
27
2884-2890
2009
Leishmania infantum
Ganapathy, K.; Kanagasabai, R.; Nguyen, T.T.; Nes, W.D.
Purification, characterization and inhibition of sterol C24-methyltransferase from Candida albicans
Arch. Biochem. Biophys.
505
194-201
2011
Candida albicans
Howard, A.L.; Liu, J.; Elmegeed, G.A.; Collins, E.K.; Ganatra, K.S.; Nwogwugwu, C.A.; Nes, W.D.
Sterol C24-methyltransferase: Physio- and stereo-chemical features of the sterol C3 group required for catalytic competence
Arch. Biochem. Biophys.
521
43-50
2012
Paracoccidioides brasiliensis
Liu, J.; Ganapathy, K.; Wywial, E.; Bujnicki, J.M.; Nwogwugwu, C.A.; Nes, W.D.
Effect of substrate features and mutagenesis of active site tyrosine residues on the reaction course catalysed by Trypanosoma brucei sterol C-24-methyltransferase
Biochem. J.
439
413-422
2011
Trypanosoma brucei
Pereira, M.; Song, Z.; Santos-Silva, L.K.; Richards, M.H.; Nguyen, T.T.; Liu, J.; de Almeida Soares, C.M.; da Silva Cruz, A.H.; Ganapathy, K.; Nes, W.D.
Cloning, mechanistic and functional analysis of a fungal sterol C24-methyltransferase implicated in brassicasterol biosynthesis
Biochim. Biophys. Acta
1801
1163-1174
2010
Paracoccidioides brasiliensis
Kaneshiro, E.S.; Johnston, L.Q.; Nkinin, S.W.; Romero, B.I.; Giner, J.L.
Sterols of Saccharomyces cerevisiae erg6 knockout mutant expressing the Pneumocystis carinii S-adenosylmethionine:sterol C-24 methyltransferase
J. Eukaryot. Microbiol.
62
298-306
2015
Pneumocystis carinii (Q96WX4), Pneumocystis carinii
Haubrich, B.A.; Collins, E.K.; Howard, A.L.; Wang, Q.; Snell, W.J.; Miller, M.B.; Thomas, C.D.; Pleasant, S.K.; Nes, W.D.
Characterization, mutagenesis and mechanistic analysis of an ancient algal sterol C24-methyltransferase: Implications for understanding sterol evolution in the green lineage
Phytochemistry
113
64-72
2015
Chlamydomonas reinhardtii (A8IJ34)
Kaneshiro, E.; Johnston, L.; Nkinin, S.; Romero, B.; Giner, J.
Sterols of Saccharomyces cerevisiae erg6 knockout mutant expressing the Pneumocystis carinii S-adenosylmethionine sterol C-24 methyltransferase (SAM SMT)
J. Eukaryot. Microbiol.
62
298-306
2015
Pneumocystis carinii (Q96WX4), Pneumocystis carinii, Pneumocystis carinii B80 (Q96WX4)
Mukherjee, S.; Xu, W.; Hsu, F.; Patel, J.; Huang, J.; Zhang, K.
Sterol methyltransferase is required for optimal mitochondrial function and virulence in Leishmania major
Mol. Microbiol.
111
65-81
2019
Leishmania major (Q4Q1I2), Leishmania major (Q4Q1I3)
Haubrich, B.; Collins, E.; Howard, A.; Wang, Q.; Snell, W.; Miller, M.; Thomas, C.; Pleasant, S.; Nes, W.
Characterization, mutagenesis and mechanistic analysis of an ancient algal sterol C24-methyltransferase Implications for understanding sterol evolution in the green lineage
Phytochemistry
113
64-72
2015
Chlamydomonas reinhardtii (A8IJ34)
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