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2.1.1.41: sterol 24-C-methyltransferase

This is an abbreviated version!
For detailed information about sterol 24-C-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.41

Reaction

S-adenosyl-L-methionine
+
5alpha-cholesta-8,24-dien-3beta-ol
=
S-adenosyl-L-homocysteine
 +
24-methylene-5alpha-cholest-8-en-3beta-ol

Synonyms

(S)-adenosyl-L-methionine:DELTA24(25)-sterol methyl transferase, 24-C-sterol methyltransferase, 24-SMT, 24-sterol C-methyltransferase, C-24 sterol methyltransferase, C24-methyltransferase, DELTA(24,25)-SMT, DELTA24-methyltransferase, DELTA24-sterol methyltransferase, Erg6, Erg6p, LMJF_36_2380, LMJF_36_2390, methyltransferase, DELTA24-sterol, PbSMT, phytosterol methyltransferase, S-adenosyl-4-methionine:sterol DELTA24-methyltransferase, S-adenosyl-L-methionine:DELTA24(23)-sterol methyltransferase, SAM:SMT, SMT, SMT protein, SMT1, SMT80, SMT90, sterol 24-C-methyltransferase, sterol C24-methyltransferase, sterol methyltransferase, STM, TbSMT, zymosterol 24-methyltransferase, zymosterol-24-methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.41 sterol 24-C-methyltransferase

KI Value

KI Value on EC 2.1.1.41 - sterol 24-C-methyltransferase

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Ki VALUE [mM]
INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.00001
(24,S),25-epiminozymosterol
-
-
0.0000017 - 0.000003
(24R)-methyl-25-thiacholesteryl iodide
0.00001
(24R,S),25-epiminolanosterol
-
-
0.0000023 - 0.0000046
(24S)-methyl-25-thiacholesteryl iodide
0.000016
(3beta,24,R,S)-24-methyl-24-thioniacholest-5-enol
-
-
0.000011 - 0.000049
24(R,S),25-epiminolanosterol
0.000025 - 0.00036
24(R,S)-25-epiminolanosterol
0.00000125 - 0.000003
25-Aza-24,25-dihydrozymosterol
0.000048
25-azacholestane
-
-
0.000015
25-Azacholesterol hydrochloride
-
-
0.000014 - 0.00039
25-azalanosterol
0.0000011 - 0.0000024
25-thiacholesterol iodide
0.000054
26,27-dehydrolanosterol
-
pH 7.5, 37°C
0.000009 - 0.029
26,27-dehydrozymosterol
0.022
5'-deoxy-5'-(methylthio)adenosine
-
-
0.072
cholesta-8,24(28)-dienol
-
pH 7.5, 30°C
0.009 - 0.489
desmosterol
0.02
ergosta-5,7,22-trienol
-
pH 7.5, 30°C
0.00071 - 0.027
ergosterol
0.058
S-isobutyladenosine
-
-
0.013
sinefungin
-
-
0.0045 - 0.022
Zymosterol
additional information
additional information
-
overview, diverse substrate and transition state analogues
-