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2.1.1.4: acetylserotonin O-methyltransferase

This is an abbreviated version!
For detailed information about acetylserotonin O-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.4

Reaction

S-adenosyl-L-methionine
+
N-acetylserotonin
=
S-adenosyl-L-homocysteine
 +
Melatonin

Synonyms

acetylserotonin methyltransferase, ASMT, ASMT1, ASMT2, COMT, HIOMT, hydroxindole-O-methyltransferase, hydroxyindole methyltransferase, hydroxyindole O-methyltransferase, hydroxyindole-O-methyl transferase, hydroxyindole-O-methyltransferase, MANES_17G050500, methyltransferase, acetylserotonin, N-acetylserotonin methyltransferase, N-acetylserotonin methyltransferase1, N-acetylserotonin O-methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.4 acetylserotonin O-methyltransferase

Inhibitors

Inhibitors on EC 2.1.1.4 - acetylserotonin O-methyltransferase

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INHIBITOR
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
Arginine vasotocin
-
-
Ca2+
-
-
caffeic acid
in vitro N-acetylserotonin methyltransferase activity is significantly and competitively inhibited by caffeic acid, a substrate of the caffeic acid O-methyltransferase, 73% inhibition at 0.01 mM, 93% at 0.1 mM
Cu2+
-
-
cysteamine
-
rat enzyme inhibited to 50% at 0.128 mM, bovine and ovine enzyme not
cysteic acid
-
-
fisetin
0.1 mM, strong inhibition of N-acetylserotonin methyltransferase activity
glutathione
-
-
Homocysteic acid
-
-
kaempferol
0.1 mM, strong inhibition of N-acetylserotonin methyltransferase activity
L-glutamate
-
inhibition is reversible, dose-dependent, no inhibition of mRNA expression
luteolin
0.1 mM, strong inhibition of N-acetylserotonin methyltransferase activity
Mg2+
-
-
morin
0.1 mM, strong inhibition of N-acetylserotonin methyltransferase activity
myricetin
0.1 mM, strong inhibition of N-acetylserotonin methyltransferase activity
N-acetylserotonin
Oxytocin
-
-
p-chloromercuribenzoate
-
-
pyridoxal 5'-phosphate
-
-
quercetin
S-adenosyl-L-homocysteine
S-adenosyl-L-methionine
Selenocysteamine
-
50% inhibition at 0.013 mM
tryptophan
-
about 30% inhibition
Vasopressin
-
-
additional information
-