2.1.1.34: tRNA (guanosine18-2'-O)-methyltransferase
This is an abbreviated version!
For detailed information about tRNA (guanosine18-2'-O)-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.34
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2.1.1.34
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thermophilus
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thermus
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d-loops
-
ribose
-
methyltransferases
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trnaphe
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adomet
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2'-o-methyltransferases
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2'-o-methylguanosine
-
analysis
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s-adenosyl-l-homocysteine
-
medicine
-
methyl-transfer
- 2.1.1.34
- thermophilus
-
thermus
-
d-loops
- ribose
- methyltransferases
- trnaphe
- adomet
-
2'-o-methyltransferases
- 2'-o-methylguanosine
- analysis
- s-adenosyl-l-homocysteine
- medicine
-
methyl-transfer
Reaction
Synonyms
methyltransferase, transfer ribonucleate guanosine 2'-, S-adenosyl-L-methionine:tRNA (guanosine-2'-O-)-methyltransferase, SpoU, TARBP1, transfer ribonucleate guanosine 2'-methyltransferase, transfer RNA (Gm18) methyltransferase, TrmH, tRNA (Gm18) 2'-O-methyltransferase, tRNA (Gm18) methyltransferase, tRNA (guanosine-2'-O-)-methyltransferase, tRNA Gm18 methyltransferase, tRNA guanosine 2'-methyltransferase
ECTree
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Substrates Products
Substrates Products on EC 2.1.1.34 - tRNA (guanosine18-2'-O)-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + Escherichia coli tRNA-Met
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in Escherichia coli tRNA-Met
-
-
-
-
?
S-adenosyl-L-methionine + guanosine18 in Escherichia coli tRNA-Ile
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in Escherichia coli tRNA-Ile
-
-
-
-
?
S-adenosyl-L-methionine + guanosine18 in Escherichia coli tRNA-Phe
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in Escherichia coli tRNA-Phe
-
-
-
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
S-adenosyl-L-methionine + guanosine18 in tRNAPhe
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNAPhe
S-adenosyl-L-methionine + guanosine18 in tRNATyr
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNATyr
S-adenosyl-L-methionine + guanosine18 in yeast tRNA-Phe
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in yeast tRNA-Phe
S-adenosyl-L-methionine + guanosine18 in yeast tRNAPhe
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in yeast tRNAPhe
S-adenosyl-L-methionine + guanosine18 in yeast tRNAPhe mutant transcript
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in yeast tRNAPhe mutant transcript
-
-
-
-
?
S-adenosyl-L-methionine + guanosine18 in yeast tRNAPhe-AGA mutant transcript
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in yeast tRNAPhe-AGA mutant transcript
-
-
-
-
?
S-adenosyl-L-methionine + guanosine18 in yeast tRNAPhe-dG18 mutant transcript
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in yeast tRNAPhe-dG18 mutant transcript
-
-
-
-
?
S-adenosyl-L-methionine + guanosine18 in yeast tRNAPhe-GAA mutant transcript
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in yeast tRNAPhe-GAA mutant transcript
-
-
-
-
?
S-adenosyl-L-methionine + guanosine18 in yeast tRNAPhe-GGA mutant transcript
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in yeast tRNAPhe-GGA mutant transcript
-
-
-
-
?
S-adenosyl-L-methionine + guanosine18 in yeast tRNAPhe-GUA mutant transcript
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in yeast tRNAPhe-GUA mutant transcript
-
-
-
-
?
S-adenosyl-L-methionine + tRNA
S-adenosyl-L-homocysteine + 2-methylthio N6(gamma,gamma,dimethylallyl)adenosine in tRNA
S-adenosyl-L-methionine + tRNA
S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanine
S-adenosyl-L-methionine + yeast tRNA-Phe
S-adenosyl-L-homocysteine + yeast tRNA-Phe containing 2'-O-methylguanine
-
-
-
-
?
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
-
unmethylated tRNATyr
-
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
-
methyl group acceptors from E. coli: methyl deficient tRNATyr, tRNAPhe, tRNAfMet
-
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
-
unmethylated tRNATyr
-
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
-
methyl group acceptors from E. coli: methyl deficient tRNATyr, tRNAPhe, tRNAfMet
-
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
Marinobacter nauticus
-
-
the organisms' tRNA contains a G residue at the 18th position adjacent to the anticodon loop, except tRNAMet, tRNAPro, and tRNAVal
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
-
-
the organisms' tRNA contains a G residue at the 18th position adjacent to the anticodon loop, except tRNAMet, tRNAPro, and tRNAVal
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
-
-
the organisms' tRNA contains a G residue at the 18th position adjacent to the anticodon loop, except tRNAMet, tRNAPro, and tRNAVal
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
-
-
the organisms' tRNA contains a G residue at the 18th position adjacent to the anticodon loop, except tRNAMet, tRNAPro, and tRNAVal
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
-
methylation at 2'-OH specifically of unmodified G18 of the ribose in the D-loop of tRNA
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
-
methylation at 2'-OH specifically of unmodified G18 of the ribose in the D-loop of tRNA
-
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
-
methylation at 2'-OH specifically of unmodified G18 of the ribose in the D-loop of tRNA
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
Q9FAC4
methylation at 2'-OH specifically of unmodified G18 of the ribose in the D-loop of tRNA
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
-
methyl group acceptor from yeast: tRNAPhe
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
-
methyl group acceptor from yeast: tRNAPhe
-
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
-
methyl group acceptor from yeast: tRNAPhe
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
-
methyl group acceptor from yeast: tRNAPhe
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
-
methyl group acceptors from E. coli: methyl deficient tRNATyr, tRNAPhe, tRNAfMet
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
-
methyl group acceptors from E. coli: methyl deficient tRNATyr, tRNAPhe, tRNAfMet
-
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
-
methyl group acceptors from Bacillus subtilis: tRNAVal, tRNALys, tRNAThr, tRNALeu
-
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
-
substrate tRNAs from E. coli, yeast, Bacillus subtilis
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
methylation at 2'-OH specifically of unmodified G18 of the ribose in the D-loop of tRNA
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
methyl group acceptor from yeast: tRNAPhe
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
methyl group acceptors from E. coli: methyl deficient tRNATyr, tRNAPhe, tRNAfMet
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
methylation at 2'-OH specifically of unmodified G18 of the ribose in the D-loop of tRNA
-
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
methyl group acceptor from yeast: tRNAPhe
-
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
methyl group acceptors from E. coli: methyl deficient tRNATyr, tRNAPhe, tRNAfMet
-
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
methylation at 2'-OH specifically of unmodified G18 of the ribose in the D-loop of tRNA
-
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
methyl group acceptor from yeast: tRNAPhe
-
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
methyl group acceptors from E. coli: methyl deficient tRNATyr, tRNAPhe, tRNAfMet
-
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
methyl group acceptors from Bacillus subtilis: tRNAVal, tRNALys, tRNAThr, tRNALeu
-
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
methyl group acceptor from yeast: tRNAPhe
-
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
methyl group acceptors from E. coli: methyl deficient tRNATyr, tRNAPhe, tRNAfMet
-
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
methylation at 2'-OH specifically of unmodified G18 of the ribose in the D-loop of tRNA
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
methyl group acceptor from yeast: tRNAPhe
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
substrate tRNAs from E. coli, yeast, Bacillus subtilis
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
methyl group acceptor from yeast: tRNAPhe
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
methylation at 2'-OH specifically of unmodified G18 of the ribose in the D-loop of tRNA
-
-
?
S-adenosyl-L-methionine + guanosine18 in tRNA
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNA
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
methyl group acceptor from yeast: tRNAPhe
-
-
?
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNAPhe
substrate yeast tRNAPhe
-
-
?
S-adenosyl-L-methionine + guanosine18 in tRNAPhe
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNAPhe
substrate yeast tRNAPhe
-
-
?
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNATyr
-
involved in post-transcriptional tRNA modification
-
-
?
S-adenosyl-L-methionine + guanosine18 in tRNATyr
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in tRNATyr
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
involved in post-transcriptional tRNA modification
-
-
?
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in yeast tRNA-Phe
-
-
-
-
?
S-adenosyl-L-methionine + guanosine18 in yeast tRNA-Phe
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in yeast tRNA-Phe
Q9FAC4
-
-
-
?
S-adenosyl-L-methionine + guanosine18 in yeast tRNA-Phe
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in yeast tRNA-Phe
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
-
-
-
?
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in yeast tRNAPhe
-
-
-
-
?
S-adenosyl-L-methionine + guanosine18 in yeast tRNAPhe
S-adenosyl-L-homocysteine + 2'-O-methylguanosine18 in yeast tRNAPhe
Q9FAC4
-
-
-
?
S-adenosyl-L-homocysteine + 2-methylthio N6(gamma,gamma,dimethylallyl)adenosine in tRNA
-
in vitro
-
?
S-adenosyl-L-methionine + tRNA
S-adenosyl-L-homocysteine + 2-methylthio N6(gamma,gamma,dimethylallyl)adenosine in tRNA
-
in vitro
-
?
S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanine
-
-
-
?
S-adenosyl-L-methionine + tRNA
S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanine
-
-
-
-
?
S-adenosyl-L-methionine + tRNA
S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanine
Q9FAC4
-
-
-
?
S-adenosyl-L-methionine + tRNA
S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanine
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
-
-
-
?
?
-
recognition region is included within the D-arm structure of tRNA-Leu, a bulge is essentially required. 4 base pairs within the D-stem enhance methyl acceptance activity. Py16Py17G18G19 sequence is important for efficient methyl tranfer
-
-
?
additional information
?
-
-
recognition region is included within the D-arm structure of tRNA-Leu, a bulge is essentially required. 4 base pairs within the D-stem enhance methyl acceptance activity. Py16Py17G18G19 sequence is important for efficient methyl tranfer
-
-
?
additional information
?
-
-
transfers a methyl group to the 2'-hydroxy group of a guanosine residue of a GG-sequence in methyl-deficient tRNATyr from E. coli 58-161
-
-
?
additional information
?
-
-
transfers a methyl group to the 2'-hydroxy group of a guanosine residue of a GG-sequence in methyl-deficient tRNATyr from E. coli 58-161
-
-
?
additional information
?
-
-
specifically methylates guanosine at position 18 in the D-loop of tRNAPhe from E. coli
-
-
?
additional information
?
-
-
specifically methylates guanosine at position 18 in the D-loop of tRNAPhe from E. coli
-
-
?
additional information
?
-
-
specifically methylates guanosine at position 18 in the D-loop of tRNAPhe from E. coli
-
-
?
additional information
?
-
-
specifically methylates guanosine at position 18 in the D-loop of tRNAPhe from E. coli
-
-
?
additional information
?
-
-
specifically methylates guanosine at position 18 in the D-loop of tRNAPhe from E. coli
-
-
?
additional information
?
-
-
enzyme hydroxylates guanosine at postion 18 in tRNA
-
-
?
additional information
?
-
-
yeast tRNAPhe mutant transcripts are prepared in which the modification site and/or other nucleotides in the D-loop are substituted by dG, inosine, or other nucleotides. Sites of methylation are confirmed with RNA sequencing or primer extension. Although the G18G19 sequence is not essential for methylation by TrmH, disruption of G18G19 severely reduces the efficiency of methyl transfer. There is strict recognition of guanosine by TrmH, in that methylation occurs at the adjacent G19 when the G18 is replaced by dG or adenosine. The fact that TrmH methylates guanosine in D-loops from 4 to 12 nucleotides in length suggests that selection of the position of guanosine within the D-loop is relatively flexible
-
-
?
additional information
?
-
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
specifically methylates guanosine at position 18 in the D-loop of tRNAPhe from E. coli
-
-
?
additional information
?
-
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
specifically methylates guanosine at position 18 in the D-loop of tRNAPhe from E. coli
-
-
?
additional information
?
-
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
specifically methylates guanosine at position 18 in the D-loop of tRNAPhe from E. coli
-
-
?
additional information
?
-
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
specifically methylates guanosine at position 18 in the D-loop of tRNAPhe from E. coli
-
-
?
additional information
?
-
Thermus thermophilus HB27 / ATCC BAA-163 / DSM 7039
-
specifically methylates guanosine at position 18 in the D-loop of tRNAPhe from E. coli
-
-
?
additional information
?
-
Thermus thermophilus HB8 / ATCC 27634 / DSM 579
-
specifically methylates guanosine at position 18 in the D-loop of tRNAPhe from E. coli
-
-
?