2.1.1.33: tRNA (guanine46-N7)-methyltransferase

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For detailed information about tRNA (guanine46-N7)-methyltransferase, go to the full flat file.

Reaction

Synonyms

7-methylguanine transfer ribonucleate methylase, m7G-methyltransferase, m7G46 methyltransferase Trm8p/Trm82p, methyltransferase like 1, methyltransferase, transfer ribonucleate guanine 7-, METTL1, N7-methylguanine methylase, PA14_05000, transfer ribonucleate guanine 7-methyltransferase, transfer RNA (m7G46) methyltransferase, Trm8�Trm82 complex, TrmB, TrMet (m7G46), tRNA (m7G46) methyltransferase, tRNA guanine 7-methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.33 tRNA (guanine46-N7)-methyltransferase

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Results	in table
6	Activating Compound
34950	AA Sequence
1	Application
1	CAS Registry Number
5	Cloned(Commentary)
11	Cofactor
2	Crystallization (Commentary)
39	Disease/ Diagnostics
15	General Information
2	General Stability
12	Inhibitors
5	Ki Value [mM]
26	KM Value [mM]
7	Localization
6	Metals/Ions
6	Molecular Weight [Da]
9	Natural Substrates/ Products (Substrates)
2	Organic Solvent Stability
51	Organism
25	PDB ID
2	pH Optimum
1	Posttranslational Modification
22	Protein Variants
13	Purification (Commentary)
2	Reaction
1	Reaction Type
25	Reference
2	Source Tissue
1	Specific Activity [micromol/min/mg]
3	Storage Stability
62	Substrates and Products (Substrate)
5	Subunits
25	Synonyms
1	Systematic Name
8	Temperature Optimum [°C]

Disease

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Disease on EC 2.1.1.33 - tRNA (guanine46-N7)-methyltransferase

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DISEASE

TITLE OF PUBLICATION

LINK TO PUBMED

Carcinoma, Hepatocellular

METTL1 overexpression is correlated with poor prognosis and promotes hepatocellular carcinoma via PTEN.

31463732

Carcinoma, Hepatocellular

The ATF/CREB site is the key element for transcription of the human RNA methyltransferase like 1(RNMTL1) gene, a newly discovered 17p13.3 gene.

12296377

Cholangiocarcinoma

N7-Methylguanosine tRNA modification enhances oncogenic mRNA translation and promotes intrahepatic cholangiocarcinoma progression.

34352206

Colonic Neoplasms

Overexpressed methyltransferase-like 1 (METTL1) increased chemosensitivity of colon cancer cells to cisplatin by regulating miR-149-3p/S100A4/p53 axis.

31866582

Lung Neoplasms

METTL1/WDR4-mediated m7G tRNA modifications and m7G codon usage promote mRNA translation and lung cancer progression.

34371184

Neoplasms

Methyltransferase-like 1 (METTL1) served as a tumor suppressor in colon cancer by activating 7-methyguanosine (m7G) regulated let-7e miRNA/HMGA2 axis.

32135185

Neoplasms

Methyltransferase-like 1 regulates lung adenocarcinoma A549 cell proliferation and autophagy via the AKT/mTORC1 signaling pathway.

33692862

Neoplasms

METTL1 overexpression is correlated with poor prognosis and promotes hepatocellular carcinoma via PTEN.

31463732

Neoplasms

METTL1-mediated m7G modification of Arg-TCT tRNA drives oncogenic transformation.

34352207

Neoplasms

Multi-omics integration of methyltransferase-like protein family reveals clinical outcomes and functional signatures in human cancer.

34285249

Neoplasms

tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cells.

25233213

Peripheral Arterial Disease

m7G Methyltransferase METTL1 Promotes Post-ischemic Angiogenesis via Promoting VEGFA mRNA Translation.

34136476

Psoriasis

Genetic Study on Small Insertions and Deletions in Psoriasis Reveals a Role in Complex Human Diseases.

31078570

Teratoma

METTL1-mediated m7G methylation maintains pluripotency in human stem cells and limits mesoderm differentiation and vascular development.

32698871

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