2.1.1.25: phenol O-methyltransferase
This is an abbreviated version!
For detailed information about phenol O-methyltransferase, go to the full flat file.
Reaction
Synonyms
methyltransferase, phenol, PMT
ECTree
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Substrates Products
Substrates Products on EC 2.1.1.25 - phenol O-methyltransferase
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REACTION DIAGRAM
S-adenosyl-L-methionine + 2,4-dibromophenol
S-adenosyl-L-homocysteine + 2,4-dibromo-1-methoxybenzene
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-
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-
?
S-adenosyl-L-methionine + 2,4-dichlorophenol
S-adenosyl-L-homocysteine + 2,4-dichloro-1-methoxybenzene
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-
-
-
?
S-adenosyl-L-methionine + 4-hydroxy-3,5-dimethoxyacetophenone
S-adenosyl-L-homocysteine + 3,4,5-trimethoxyacetophenone
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-
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?
S-adenosyl-L-methionine + 4-hydroxy-3,5-dimethoxybenzaldehyde
S-adenosyl-L-homocysteine + 3,4,5-trimethoxybenzaldehyde
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-
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?
S-adenosyl-L-methionine + 4-hydroxy-3,5-dimethoxybenzoic acid
S-adenosyl-L-homocysteine + 3,4,5-trimethoxybenzoic acid
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-
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?
S-adenosyl-L-methionine + 4-hydroxy-3-methoxyacetophenone
S-adenosyl-L-homocysteine + 3,4-dimethoxyacetophenone
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?
S-adenosyl-L-methionine + 4-hydroxy-3-methoxybenzaldehyde
S-adenosyl-L-homocysteine + 3,4-dimethoxybenzaldehyde
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?
S-adenosyl-L-methionine + 4-hydroxy-3-methoxybenzoic acid
S-adenosyl-L-homocysteine + 3,4-dimethoxybenzoic acid
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-
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?
S-adenosyl-L-methionine + acetaminophen
S-adenosyl-L-homocysteine + N-(4-methoxyphenyl)-acetamide
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-
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?
S-adenosyl-L-methionine + m-bromophenol
S-adenosyl-L-homocysteine + m-bromoanisole
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-
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?
S-adenosyl-L-methionine + m-chlorophenol
S-adenosyl-L-homocysteine + m-chloroanisole
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?
S-adenosyl-L-methionine + m-methoxyphenol
S-adenosyl-L-homocysteine + 1,3-dimethoxybenzene
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?
S-adenosyl-L-methionine + m-nitrophenol
S-adenosyl-L-homocysteine + m-nitroanisole
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?
S-adenosyl-L-methionine + o-chlorophenol
S-adenosyl-L-homocysteine + o-chloroanisole
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?
S-adenosyl-L-methionine + o-methoxyphenol
S-adenosyl-L-homocysteine + veratrole
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?
S-adenosyl-L-methionine + o-methylphenol
S-adenosyl-L-homocysteine + o-methylanisole
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?
S-adenosyl-L-methionine + p-chlorophenol
S-adenosyl-L-homocysteine + p-chloroanisole
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?
S-adenosyl-L-methionine + p-ethylphenol
S-adenosyl-L-homocysteine + p-ethylanisole
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-
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?
S-adenosyl-L-methionine + p-hydroxyacetanilide
S-adenosyl-L-homocysteine + p-methoxyacetanilide
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?
S-adenosyl-L-methionine + p-methoxyphenol
S-adenosyl-L-homocysteine + 1,4-dimethoxybenzene
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?
S-adenosyl-L-methionine + p-methylphenol
S-adenosyl-L-homocysteine + p-methylanisole
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-
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?
additional information
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3-methoxy- and 3,5-dimethoxy-substituted 4-hydroxy-benzaldehydes, -benzoic acids, and -acetophenones are the preferred substrates. The corresponding 3,4-dihydroxy compounds are methylated relatively slowly, while the 3-hydroxy-4-methoxy compounds are almost inactive as substrates. Substituents in both the 2 and 4 positions relative to the hydroxyl group appear to be essential for significant enzyme attack of a substrate. Xenobiotic compounds such as 2,4-dichlorophenol and 2,4-dibromophenol are methylated almost as readily as 4-hydroxy-3-methoxyacetophenone. No substrates: homovanillic acid, caffeic acid, ferulic acid
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?
S-adenosyl-L-homocysteine + anisole
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?
S-adenosyl-L-methionine + phenol
S-adenosyl-L-homocysteine + anisole
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?