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2.1.1.20: glycine N-methyltransferase

This is an abbreviated version!
For detailed information about glycine N-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.20

Reaction

S-adenosyl-L-methionine
+
glycine
=
S-adenosyl-L-homocysteine
+
sarcosine

Synonyms

4S polycyclic aromatic hydrocarbon binding protein, glycine methyltransferase, glycine N-methyltransferase, glycine-N methyltransferase, GNMT, Gnmt gene product, methyltransferase, glycine, S-adenosyl-L-methionine:glycine methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.20 glycine N-methyltransferase

Systematic Name

Systematic Name on EC 2.1.1.20 - glycine N-methyltransferase

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SYSTEMATIC NAME
IUBMB Comments
S-adenosyl-L-methionine:glycine N-methyltransferase
This enzyme is thought to play an important role in the regulation of methyl group metabolism in the liver and pancreas by regulating the ratio between S-adenosyl-L-methionine and S-adenosyl-L-homocysteine. It is inhibited by 5-methyltetrahydrofolate pentaglutamate [4]. Sarcosine, which has no physiological role, is converted back into glycine by the action of EC 1.5.8.3, sarcosine dehydrogenase.