2.1.1.2: guanidinoacetate N-methyltransferase

This is an abbreviated version!
For detailed information about guanidinoacetate N-methyltransferase, go to the full flat file.

Reaction

Synonyms

GA methylpherase, GAA methyltransferase, GAMT, guanidinoacetate methyltransferase, guanidinoacetate N-methyltransferase, guanidinoacetate transmethylase, guanidoacetate methyltransferase, methionine-guanidinoacetic transmethylase, MIM 601240, N-guanidinoacetate methyltransferase, S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.2 guanidinoacetate N-methyltransferase

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Results	in table
17	Activating Compound
368	AA Sequence
7	Application
1	CAS Registry Number
8	Cloned(Commentary)
4	Cofactor
3	Crystallization (Commentary)
324	Disease/ Diagnostics
6	Expression
7	General Information
1	General Stability
20	Inhibitors
5	Ki Value [mM]
22	KM Value [mM]
2	Localization
4	Metals/Ions
8	Molecular Weight [Da]
22	Natural Substrates/ Products (Substrates)
44	Organism
6	Pathway
16	PDB ID
6	pH Optimum
41	Protein Variants
5	Purification (Commentary)
4	Reaction
6	Reaction Type
43	Reference
114	Source Tissue
19	Specific Activity [micromol/min/mg]
3	Storage Stability
38	Substrates and Products (Substrate)
3	Subunits
46	Synonyms
1	Systematic Name
1	Temperature Optimum [°C]
1	Temperature Stability [°C]
8	Turnover Number [1/s]

Substrates Products

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Substrates Products on EC 2.1.1.2 - guanidinoacetate N-methyltransferase

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SUBSTRATE

PRODUCT                       

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

Reversibility
r=reversible
ir=irreversible
?=not specified

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

27 entries

S-adenosyl-L-methionine + guanidinoacetic acid + glutathione

?

Mus musculus

-

assay at pH 7.4, 37°C, 1 h, reaction stopped with 5% trichloroacetic acid

703632

-

-

?

additional information

?

-

2 entries

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Acomys cahirinus

-

-

702888

-

-

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Bos taurus

-

S-adenosyl-L-methionine is the only possible methyl donor

485199

-

485199

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Bos taurus

-

biosynthesis of creatine

485199

-

485199

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Branchiostoma belcheri

Q3S316

-

686291

-

-

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Cavia porcellus

-

S-adenosyl-L-methionine is the only possible methyl donor

485199

-

485199

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Cavia porcellus

-

biosynthesis of creatine

485199

-

485199

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Homo sapiens

-

-

687944, 688183, 689013, 705727

-

-

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Mus musculus

-

-

485207

-

485207

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Mus musculus

-

-

687352, 687899, 688183, 690096, 705726, 705727

-

-

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Oryctolagus cuniculus

-

S-adenosyl-L-methionine is the only possible methyl donor

485199

-

485199

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Oryctolagus cuniculus

-

biosynthesis of creatine

485199

-

485199

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Rattus norvegicus

-

-

485202

-

485202

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Rattus norvegicus

-

-

485203

-

485203

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Rattus norvegicus

-

-

485204

-

485204

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Rattus norvegicus

-

-

485205

-

485205

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Rattus norvegicus

-

-

485206

-

485206

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Rattus norvegicus

-

-

485209

-

485209

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Rattus norvegicus

-

-

485211

-

485211

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Rattus norvegicus

-

-

701624

-

-

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Rattus norvegicus

P10868

-

485208

-

485208

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Rattus norvegicus

P10868

-

485210

-

485210

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Rattus norvegicus

P10868

-

661103

-

-

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Sus scrofa

-

-

485200

-

485200

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Sus scrofa

-

-

485201

-

485201

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Sus scrofa

-

-

705297

-

-

ir

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Sus scrofa

-

S-adenosyl-L-methionine is the only possible methyl donor

485199

-

485199

?

S-adenosyl-L-methionine + guanidinoacetate

S-adenosyl-L-homocysteine + creatine

Sus scrofa

-

biosynthesis of creatine

485199

-

485199

?

additional information

?

-

Homo sapiens

-

since the L197P mutation in the exon 6 of the guanidinoacetate N-methyltransferase gene leaves the isoform B of the enzyme unaffected, the occurrence of biochemical alterations and disease in this subject testifies against the possibility that isoform B has guanidinoacetate N-methyltransferase activity

676024

-

-

?

additional information

?

-

Mus musculus

-

together with creatine/phosphocreatine shuttle system involved in brain energy homeostasis through a neuron-glial relationship

661657

-

-

?