2.1.1.17: phosphatidylethanolamine N-methyltransferase
This is an abbreviated version!
For detailed information about phosphatidylethanolamine N-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.17
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2.1.1.17
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phosphatidylcholine
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choline
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homocysteine
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cytidylyltransferase
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cdp-choline
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betaine
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s-adenosylhomocysteine
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ctp:phosphocholine
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cdp-diacylglycerol
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phosphatidyl-n,n-dimethylethanolamine
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phosphatidyl-n-monomethylethanolamine
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choline-deficient
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transmethylation
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n-methyltransferases
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kennedy
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adomet
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vance
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phosphatidylmonomethylethanolamine
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medicine
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ptdcho
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analysis
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phosphatidyldimethylethanolamine
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mthfd1
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remethylation
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cholinephosphotransferase
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adohcy
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choline-supplemented
- 2.1.1.17
- phosphatidylcholine
- choline
- homocysteine
- cytidylyltransferase
- cdp-choline
- betaine
- s-adenosylhomocysteine
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ctp:phosphocholine
- cdp-diacylglycerol
- phosphatidyl-n,n-dimethylethanolamine
- phosphatidyl-n-monomethylethanolamine
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choline-deficient
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transmethylation
- n-methyltransferases
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kennedy
- adomet
-
vance
- phosphatidylmonomethylethanolamine
- medicine
-
ptdcho
- analysis
- phosphatidyldimethylethanolamine
- mthfd1
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remethylation
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cholinephosphotransferase
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adohcy
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choline-supplemented
Reaction
Synonyms
lipid methyl transferase, LMTase, methyltransferase, phosphatidylethanolamine, PE N-MTase, PE-NMT, PEMT, PEMT shorter isoform, phosphatidylethanolamine methyltransferase, phosphatidylethanolamine N-methyltransferase, phosphatidylethanolamine-N-methylase, phosphatidylethanolamine-N-methyltransferase, phosphatidylethanolamine-S-adenosylmethionine methyltransferase, phospholipid N-methyltransferase, PmtA, PmtX1, PmtX3
ECTree
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Organism
Organism on EC 2.1.1.17 - phosphatidylethanolamine N-methyltransferase
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Neogale vison
5-6-months old farm-bred mink. Mink fed on 67LNGB diet (67% extracted lipids from natural gas-utilising bacteria, fed for 25 d, total phosphatidylethanolamine 25.7 mg/g) have a significantly higher homocysteine plasma concentrations, plasma total phospholipids, phosphatidylcholine, lysophosphatidylcholine and phospholipids are significantly lower and the phosphatidylethanolamine:phosphatidylcholine ratio in plasma increases significantly compared to SB diet (0% extracted lipids from natural gas-utilising bacteria, but 100% soyabean oil, fed for 25 d, total phosphatidylethanolamine 0.04 mg/g). Plasma homocysteine is negatively correlated with phosphatidylcholine (r = -0.74). There is a significant negative correlation between plasma homocysteine and total phospholipids (r = -0.022). Faecal excretion of phosphatidylcholine, lysophosphatidylcholine and phosphatidylethanolamine is higher in the mink fed the 67LNGB diet than in those fed the SB diet, and significantly higher in mink fed the 67LNGB diet than in animal fed the 17LNGB (17% extraceted lipids from natural gas-utilising bacteria, fed for 25 d, total phosphatidylethanolamine 2.6 mg/g) diet.
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phosphatidylethanolamine N-methyltransferase is used to radioisotopically label the envelope of Autographa californica recombinant strain vGFPuv through the methylation of phosphatidylethanolamine. The modification of envelope phospholipids by phosphatidylethanolamine N-methyltransferase does not affect the infectivity of Autographa californica recombinant strain vGFPuv.
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fetuses (embryonic day 17) Pemt -/- and wild type mice and 12-week-old Pemt -/- and wild type mice. For E17 fetal brain microarrays, 11 separate oligoarrays (comparing wild type and Pemt -/-) including 4 dye-flip experiments are perfomed and indentified differntially expressed genes: 107 significant genes with increased expression and 379 significant genes with decreased expression. For adult brain microarrays, 8 separate oligoarrays (comparing wild type and Pemt -/-) including 4 dye-flip experiments are perfomed and identified differentially expressed genes: 381 significant genes with increased expression and 1037 significant genes with decreased expression.
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485164, 485165, 485167, 485168, 485169, 485170, 485171, 485172, 485173, 485174, 485180, 485181, 485183, 485184, 485186, 485188, 485189, 485191, 485192, 485195
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male Sprague-Dawley rats of 125-149 g. Diabetes and all-trans-retinoic acid administration decrease the hepatic phosphatidylethanolamine:phosphatidylcholine ratio by 37% compared to control values
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male Wistar rats weighing 180-200 g. 30-40% less phosphatidylcholine is generated in hepatocytes from ethanol-fed rats as compared to controls. Hepatocytes isolated from rats fed the betaine-supplemented ethanol diet have significantly higher phosphatidylcholine generation compared to hepatocytes from ethanol-fed rats.
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