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2.1.1.17: phosphatidylethanolamine N-methyltransferase

This is an abbreviated version!
For detailed information about phosphatidylethanolamine N-methyltransferase, go to the full flat file.

Word Map on EC 2.1.1.17

Reaction

S-adenosyl-L-methionine
+
phosphatidylethanolamine
=
S-adenosyl-L-homocysteine
 +
phosphatidyl-N-methylethanolamine

Synonyms

lipid methyl transferase, LMTase, methyltransferase, phosphatidylethanolamine, PE N-MTase, PE-NMT, PEMT, PEMT shorter isoform, phosphatidylethanolamine methyltransferase, phosphatidylethanolamine N-methyltransferase, phosphatidylethanolamine-N-methylase, phosphatidylethanolamine-N-methyltransferase, phosphatidylethanolamine-S-adenosylmethionine methyltransferase, phospholipid N-methyltransferase, PmtA, PmtX1, PmtX3

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.17 phosphatidylethanolamine N-methyltransferase

Organism

Organism on EC 2.1.1.17 - phosphatidylethanolamine N-methyltransferase

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ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
strain USDA110
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Manually annotated by BRENDA team
strain USDA110
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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UniProt
Manually annotated by BRENDA team
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Manually annotated by BRENDA team
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Manually annotated by BRENDA team
Neogale vison
5-6-months old farm-bred mink. Mink fed on 67LNGB diet (67% extracted lipids from natural gas-utilising bacteria, fed for 25 d, total phosphatidylethanolamine 25.7 mg/g) have a significantly higher homocysteine plasma concentrations, plasma total phospholipids, phosphatidylcholine, lysophosphatidylcholine and phospholipids are significantly lower and the phosphatidylethanolamine:phosphatidylcholine ratio in plasma increases significantly compared to SB diet (0% extracted lipids from natural gas-utilising bacteria, but 100% soyabean oil, fed for 25 d, total phosphatidylethanolamine 0.04 mg/g). Plasma homocysteine is negatively correlated with phosphatidylcholine (r = -0.74). There is a significant negative correlation between plasma homocysteine and total phospholipids (r = -0.022). Faecal excretion of phosphatidylcholine, lysophosphatidylcholine and phosphatidylethanolamine is higher in the mink fed the 67LNGB diet than in those fed the SB diet, and significantly higher in mink fed the 67LNGB diet than in animal fed the 17LNGB (17% extraceted lipids from natural gas-utilising bacteria, fed for 25 d, total phosphatidylethanolamine 2.6 mg/g) diet.
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Manually annotated by BRENDA team
phosphatidylethanolamine N-methyltransferase is used to radioisotopically label the envelope of Autographa californica recombinant strain vGFPuv through the methylation of phosphatidylethanolamine. The modification of envelope phospholipids by phosphatidylethanolamine N-methyltransferase does not affect the infectivity of Autographa californica recombinant strain vGFPuv.
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Manually annotated by BRENDA team