2.1.1.14: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase
This is an abbreviated version!
For detailed information about 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase, go to the full flat file.
Word Map on EC 2.1.1.14
-
2.1.1.14
-
methyltetrahydrofolate
-
cobalamin-dependent
-
tetrahydrofolate
-
n5-methyl
-
overoxidation
-
s-bacillithiolation
-
bacillithiol
-
analysis
- 2.1.1.14
- methyltetrahydrofolate
-
cobalamin-dependent
- tetrahydrofolate
-
n5-methyl
-
overoxidation
-
s-bacillithiolation
- bacillithiol
- analysis
Reaction
Synonyms
5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferase, AtMetE, cobalamin-independent methionine synthase, cobalamin-independent methionine synthase (MetE), homocysteine methylase, Met-8, MET1, Met6, Met6p, MetE, methionine synthase MetE, methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase, methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase, MS1, PpMetE, tetrahydropteroyltriglutamate methyltransferase, TM1286
ECTree
2.1.1.14 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferaseAdvanced search results
results (
results (Reference
top
Reference on EC 2.1.1.14 - 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase
Please use the Reference Search for a specific query.
Please wait a moment until all data is loaded. This message will disappear when all data is loaded.
REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Guest, J.R.; Friedman, S.; Foster, M.A.; Tejerina, G.; Woods, D.D.
Transfer of the methyl group from N5-methyltetrahydrofolates to homocysteine in Escherichia coli
Biochem. J.
92
497-504
1964
Escherichia coli
Gonzalez, J.C.; Banerjee, R.V.; Huang, S.; Sumner, J.S.; Matthews, R.G.
Comparison of cobalamin-independent and cobalamin-dependent methionine synthases from Escherichia coli: two solutions to the same chemical problem
Biochemistry
31
6045-6056
1992
Escherichia coli
Zhou, Z.S.; Smith, A.E.; Matthews, R.G.
L-Selenohomocysteine: One-step synthesis from L-selenomethionine and kinetic analysis as substrate for methionine synthases
Bioorg. Med. Chem. Lett.
10
2471-2475
2000
Escherichia coli
Peariso, K.; Zhou, Z.S.; Smith, A.E.; Matthews, R.G.; Penner-Hahn, J.E.
characterization of the zinc sites in cobalamin-independent and cobalamin-dependent methionine synthase using zinc and selenium X-ray absorption spectroscopy
Biochemistry
40
987-993
2001
Escherichia coli
Madison, J.T.
Sulphur metabolism. F. Enzymes involved in the synthesis of methionine
Methods Plant Biochem.
3
361-369
1990
Daucus carota, Hordeum vulgare, Phaseolus sp., Pisum sativum, Spinacia oleracea
-
Whitefield, C.D.; Steers, E.J.; Weissbach, H.
Purification and properties of 5-methyltetrahydropteroyltriglutamate-homocysteine transmethylase
J. Biol. Chem.
245
390-401
1970
Escherichia coli
Taylor, R.T.; Weissbach, H.
N5-Methyltetrahydrofolate-homocysteine methyltransferases
The Enzymes, 3rd Ed. (Boyer, P. D. , ed. )
9
121-165
1973
Klebsiella aerogenes, Saccharomyces cerevisiae, Auxenochlorella pyrenoidosa, Escherichia coli, Neurospora crassa, Salmonella enterica subsp. enterica serovar Typhimurium
-
Salem, A.R.; Pattison, J.R.; Foster, M.A.
Folic acid and the methylation of homocysteine by Bacillus subtilis
Biochem. J.
126
993-1004
1972
Bacillus subtilis
Burton, E.; Sakami, W.
Methionine synthesis (Yeast)
Methods Enzymol.
17B
388-392
1971
Saccharomyces cerevisiae
-
Chu, J.; Shoeman, R.; Hart, J.; Coleman, T.; Mazaitis, A.; Kelker, N.; Brot, N.; Weissbach, H.
Cloning and expression of the metE gene in Escherichia coli
Arch. Biochem. Biophys.
239
467-474
1985
Escherichia coli
Burton, E.G.; Metzenberg, R.L.
Regulation of methionine biosythesis in Neurospora crassa
Arch. Biochem. Biophys.
168
219-229
1975
Neurospora crassa
Eichel, J.; Gonzalez, J.C.; Hotze, M.; Matthews, R.G.; Schroeder, J.
Vitamin-B12-independent methionine synthase from a higher plant (Catharanthus roseus). Molecular characterization, regulation, heterologous expression, and enzyme properties
Eur. J. Biochem.
230
1053-1058
1995
Catharanthus roseus
Gonzalez, J.C.; Peariso, K.; Penner-Hahn, J.E.; Matthews, R.G.
Cobalamin-independent methionine synthase from Escherichia coli: A zinc metalloenzyme
Biochemistry
35
12228-12234
1996
Escherichia coli
Zeh, M.; Leggewie, G.; Hoefgen, R.; Hesse, H.
Cloning and characterization of a cDNA encoding a cobalamin-independent methionine synthase from potato (Solanum tuberosum L.)
Plant Mol. Biol.
48
255-265
2002
Solanum tuberosum
Burton, E.G.; Sakami, W.
The formation of methionine from the monoglutamate form of methyltetrahydrofolate by higher plants
Biochem. Biophys. Res. Commun.
36
228-234
1969
Phaseolus vulgaris
Eckermann, C.; Eichel, J.; Schroder, J.
Plant methionine synthase: new insights into properties and expression
Biol. Chem.
381
695-703
2000
Catharanthus roseus
Huang, L.; Li, D.Y.; Wang, S.X.; Zhang, S.M.; Chen, J.H.; Wu, X.F.
Cloning and identification of methionine synthase gene from Pichia pastoris
Acta Biochim. Biophys. Sin.
37
371-378
2005
Komagataella pastoris (Q6GYJ7), Komagataella pastoris
Ferrer, J.L.; Ravanel, S.; Robert, M.; Dumas, R.
Crystal structures of cobalamin-independent methionine synthase complexed with zinc, homocysteine, and methyltetrahydrofolate
J. Biol. Chem.
279
44235-44238
2004
Arabidopsis thaliana
Hondorp, E.R.; Matthews, R.G.
Oxidative stress inactivates cobalamin-independent methionine synthase (MetE) in Escherichia coli
PLoS Biol.
2
1738-1753
2004
Escherichia coli
Pejchal, R.; Ludwig, M.L.
Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication
PLoS Biol.
3
254-265
2005
Thermotoga maritima
-
Fu, T.M.; Zhang, X.Y.; Li, L.F.; Liang, Y.H.; Su, X.D.
Preparation, crystallization and preliminary X-ray analysis of the methionine synthase (MetE) from Streptococcus mutans
Acta Crystallogr. Sect. F
62
984-985
2006
Streptococcus mutans
Suliman, H.S.; Sawyer, G.M.; Appling, D.R.; Robertus, J.D.
Purification and properties of cobalamin-independent methionine synthase from Candida albicans and Saccharomyces cerevisiae
Arch. Biochem. Biophys.
441
56-63
2005
Saccharomyces cerevisiae, Candida albicans
Taurog, R.E.; Jakubowski, H.; Matthews, R.G.
Synergistic, random sequential binding of substrates in cobalamin-independent methionine synthase
Biochemistry
45
5083-5091
2006
Escherichia coli, Escherichia coli pJG816
Taurog, R.E.; Matthews, R.G.
Activation of methyltetrahydrofolate by cobalamin-independent methionine synthase
Biochemistry
45
5092-5102
2006
Escherichia coli
Pejchal, R.; Ludwig, M.L.
Cobalamin-independent methionine synthase (MetE): a face-to-face double barrel that evolved by gene duplication
PLoS Biol.
3
e31
2005
Arabidopsis thaliana (O50008), Saccharomyces cerevisiae (P05694), Escherichia coli (P25665), Thermotoga maritima (Q9X112), Thermotoga maritima
Hondorp, E.R.; Matthews, R.G.
Oxidation of cysteine 645 of cobalamin-independent methionine synthase causes a methionine limitation in Escherichia coli
J. Bacteriol.
191
3407-3410
2009
Escherichia coli
Gonzalez-Verdejo, C.; Die, J.; Nadal, S.; Di Pietro, A.; Barandiaran, X.; Cubero, J.; Roman, B.
Isolation and expression analysis of a cobalamin-independent methionine synthase gene from the parasitic plant Orobanche ramosa
Sci. Hortic.
116
337-341
2008
Phelipanche ramosa (B2VQE0)
-
Fu, T.M.; Almqvist, J.; Liang, Y.H.; Li, L.; Huang, Y.; Su, X.D.
Crystal structures of cobalamin-independent methionine synthase (MetE) from Streptococcus mutans: a dynamic zinc-inversion model
J. Mol. Biol.
412
688-697
2011
Streptococcus mutans (Q8CWX6), Streptococcus mutans
Fujiwara, K.; Taguchi, H.
Mechanism of methionine synthase overexpression in chaperonin-depleted Escherichia coli
Microbiology
158
917-924
2012
Escherichia coli
Mordukhova, E.A.; Pan, J.G.
Evolved cobalamin-independent methionine synthase (MetE) improves the acetate and thermal tolerance of Escherichia coli
Appl. Environ. Microbiol.
79
7905-7915
2013
Escherichia coli (P25665), Escherichia coli
Yang, Q.; Li, Y.; Yang, H.; Rang, J.; Tang, S.; He, L.; Li, L.; Ding, X.; Xia, L.
Proteomic insights into metabolic adaptation to deletion of metE in Saccharopolyspora spinosa
Appl. Microbiol. Biotechnol.
99
8629-8641
2015
Saccharopolyspora spinosa
Ubhi, D.K.; Robertus, J.D.
The cobalamin-independent methionine synthase enzyme captured in a substrate-induced closed conformation
J. Mol. Biol.
427
901-909
2015
Candida albicans (P82610), Candida albicans ATCC MYA-2876 (P82610)
Saint-Macary, M.E.; Barbisan, C.; Gagey, M.J.; Frelin, O.; Beffa, R.; Lebrun, M.H.; Droux, M.
Methionine biosynthesis is essential for infection in the rice blast fungus Magnaporthe oryzae
PLoS ONE
10
e0111108
2015
Pyricularia oryzae
Wheatley, R.W.; Ng, K.K.S.; Kapoor, M.
Fungal cobalamin-independent methionine synthase Insights from the model organism, Neurospora crassa
Arch. Biochem. Biophys.
590
125-137
2016
Neurospora crassa (Q8X1E4), Neurospora crassa
Romek, K.M.; Krzeminska, A.; Remaud, G.S.; Julien, M.; Paneth, P.; Robins, R.J.
Insights into the role of methionine synthase in the universal 13C depletion in O- and N-methyl groups of natural products
Arch. Biochem. Biophys.
635
60-65
2017
synthetic construct
Sahu, U.; Rajendra, V.K.H.; Kapnoor, S.S.; Bhagavat, R.; Chandra, N.; Rangarajan, P.N.
Methionine synthase is localized to the nucleus in Pichia pastoris and Candida albicans and to the cytoplasm in Saccharomyces cerevisiae
J. Biol. Chem.
292
14730-14746
2017
Komagataella pastoris (A0A1B2JIW1)
Ju, C.; Kong, D.; Lee, Y.; Ge, G.; Song, Y.; Liu, J.; Kwak, J.M.
Methionine synthase 1 provides methionine for activation of the GLR3.5 Ca2+ channel and regulation of germination in Arabidopsis
J. Exp. Bot.
71
178-187
2020
Arabidopsis thaliana (O50008)
Endo, S.; Maeda, T.; Kawame, T.; Iwai, N.; Wachi, M.
RNase E/G-dependent degradation of metE mRNA, encoding methionine synthase, in Corynebacterium glutamicum
J. Gen. Appl. Microbiol.
65
47-52
2019
Corynebacterium glutamicum, Corynebacterium glutamicum ATCC 31831
Ubhi, D.; Robertus, J.
The cobalamin-independent methionine synthase enzyme captured in a substrate-induced closed conformation
J. Mol. Biol.
427
901-909
2015
Candida albicans (P82610)
html completed
