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2.1.1.13: methionine synthase

This is an abbreviated version!
For detailed information about methionine synthase, go to the full flat file.

Word Map on EC 2.1.1.13

Reaction

5-methyltetrahydrofolate
+
L-homocysteine
=
tetrahydrofolate
 +
L-methionine

Synonyms

5-methyltetrahydrofolate homocysteine methyltransferase, 5-methyltetrahydrofolate-homocysteine methyltransferase, 5-methyltetrahydrofolate-homocysteine S-methyltransferase, 5-methyltetrahydrofolate-homocysteine transmethylase, B12 N5-methyltetrahydrofolate homocysteine methyltransferase, B12-dependent methionine synthase, cobalamin-dependent methionine synthase, folate-dependent methionine synthase, Met6p, MetH, methionine synthase, methionine synthetase, methyltetrahydrofolate-homocysteine vitamin B12 methyltransferase, methyltransferase, methyltetrahydrofolate-homocysteine, MetS, MS, MS1, MTR, N-methyltetrahydrofolate:L-homocysteine methyltransferase, N5-methyltetrahydrofolate methyltransferase, N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase, N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase, tetrahydrofolate methyltransferase, tetrahydropteroylglutamate methyltransferase, tetrahydropteroylglutamic methyltransferase, vitamin B12 methyltransferase

ECTree

     2 Transferases
         2.1 Transferring one-carbon groups
             2.1.1 Methyltransferases
                2.1.1.13 methionine synthase

Specific Activity

Specific Activity on EC 2.1.1.13 - methionine synthase

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SPECIFIC ACTIVITY [µmol/min/mg]
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
0.00017
-
muscle
0.00043
-
intestine
0.0005
-
recombinant enzyme from crude extract, in 0.2 M potassium phosphate buffer (pH 7.2), at 37°C
0.0023
-
pancreas
0.003
-
brain
0.0073
-
kidney
0.0327
-
liver
1.54
-
recombinant enzyme after 3669fold purification, in 0.2 M potassium phosphate buffer (pH 7.2), at 37°C
1.94
-
after 279fold purification at 37°C
2.53
-
crude cell extract at 37°C
9.3 - 11.7
-
-
additional information