2.1.1.13: methionine synthase

This is an abbreviated version!
For detailed information about methionine synthase, go to the full flat file.

Reaction

Synonyms

5-methyltetrahydrofolate homocysteine methyltransferase, 5-methyltetrahydrofolate-homocysteine methyltransferase, 5-methyltetrahydrofolate-homocysteine S-methyltransferase, 5-methyltetrahydrofolate-homocysteine transmethylase, B12 N5-methyltetrahydrofolate homocysteine methyltransferase, B12-dependent methionine synthase, cobalamin-dependent methionine synthase, folate-dependent methionine synthase, Met6p, MetH, methionine synthase, methionine synthetase, methyltetrahydrofolate-homocysteine vitamin B12 methyltransferase, methyltransferase, methyltetrahydrofolate-homocysteine, MetS, MS, MS1, MTR, N-methyltetrahydrofolate:L-homocysteine methyltransferase, N5-methyltetrahydrofolate methyltransferase, N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase, N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase, tetrahydrofolate methyltransferase, tetrahydropteroylglutamate methyltransferase, tetrahydropteroylglutamic methyltransferase, vitamin B12 methyltransferase

ECTree

     2 Transferases

         2.1 Transferring one-carbon groups

             2.1.1 Methyltransferases

                2.1.1.13 methionine synthase

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Results	in table
20	Activating Compound
32678	AA Sequence
10	Application
1	CAS Registry Number
10	Cloned(Commentary)
99	Cofactor
10	Crystallization (Commentary)
27596	Disease/ Diagnostics
3	Expression
3	General Information
10	General Stability
20	IC50 Value
20	Inhibitors
2	Ki Value [mM]
25	KM Value [mM]
6	Localization
10	Metals/Ions
21	Molecular Weight [Da]
5	Natural Substrates/ Products (Substrates)
1342	Organism
13	Pathway
32	PDB ID
7	pH Optimum
3	pH Range
3	pH Stability
23	Protein Variants
30	Purification (Commentary)
28	Reaction
1	Reaction Type
111	Reference
1	Renatured (Commentary)
70	Source Tissue
40	Specific Activity [micromol/min/mg]
8	Storage Stability
83	Substrates and Products (Substrate)
9	Subunits
40	Synonyms
1	Systematic Name
4	Temperature Optimum [°C]
2	Temperature Range [°C]
3	Temperature Stability [°C]
4	Turnover Number [1/s]

Natural Substrates Products

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Natural Substrates Products on EC 2.1.1.13 - methionine synthase

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NATURAL SUBSTRATE

NATURAL PRODUCT

REACTION DIAGRAM

ORGANISM

UNIPROT

COMMENTARY
(Substrate)

LITERATURE
(Substrate)

COMMENTARY
(Product)

LITERATURE
(Product)

REVERSIBILITY
r=reversible
ir=irreversible
?=not specified

5-methyltetrahydrofolate + L-homocysteine

tetrahydrofolate + L-methionine

3 entries

N5-methyltetrahydrofolate + L-homocysteine

tetrahydrofolate + L-methionine

Aspergillus nidulans

-

transcription is not regulated by Met, but is enhanced by homocysteine and repressed by choline and betaine. Synthesis of the enzyme is also regulated posttranscriptionally

657836

-

-

?

5-methyltetrahydrofolate + L-homocysteine

tetrahydrofolate + L-methionine

Homo sapiens

-

homocysteine increases methionine synthase mRNA level

658413

-

-

?

5-methyltetrahydrofolate + L-homocysteine

tetrahydrofolate + L-methionine

Hordeum vulgare

-

gene expression is induced by light, but more strongly induced under salt, drought and cold stresses and by treatment with ABA or H2O2

660282

-

-

?

5-methyltetrahydrofolate + L-homocysteine

tetrahydrofolate + L-methionine

Sus scrofa

-

methionine biosynthesis

437712, 441173

-

-

?